DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManII and aman-1

DIOPT Version :9

Sequence 1:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_508811.1	Gene:	aman-1 / 180749	WormBaseID:	WBGene00018877	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	977	Identity:	371/977 - (37%)
Similarity:	550/977 - (56%)	Gaps:	86/977 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VFFCALGCLIHDADLRSIQPKASQCGYQSCHPT--KPNMLNVHLVAHTHDDVGWLKTVDQYYYGS 72
            |.|..||.|:    :.|.|    .|.:.:||..  .||::..||:.|||||:||:||||||::|:
Worm     5 VIFLFLGLLV----IYSSQ----DCAWNTCHKVDQDPNVITAHLIPHTHDDLGWIKTVDQYFWGA 61

  Fly    73 ETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKWWKEQKPKVQEAVKMLVEQGRLEFIGG 137
            :.::...|||||.::|::.||::|::||.:.|:.|.::|:.......:..::.||:.|::|.|||
Worm    62 KPELVPVGVQYIYNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGG 126

  Fly   138 AWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFF 202
            .|..|||||:||..:|||.:.||:.|...|||||:|..||||||||||||||:::.:||:..::|
Worm   127 GWVQNDEATSHYVDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYF 191

  Fly   203 GRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGALYN-NYQAPDGFCFDILCNDAPIIDGKH 266
            .|:.|.:|..||..|..|.:|:.|.::.:. .||:||.:| ||..|:|||:|.||.|.||:|..:
Worm   192 ARIHYLEKQIRLKNKTLEFMWNTSDDITDN-KLFTGAFFNDNYGPPEGFCWDSLCGDDPIMDNLN 255

  Fly   267 SPDNNVKERIDTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSN 331
            ....||||::|.|:|..|.|:.:..||.:::.||.||.|..|..:|.||||||:|.|  ......
Worm   256 IEGYNVKEKVDAFVDHVKNQAAHQSTNQVMLLMGSDFQYTNANSWYVNLDKLIKYVN--ADTSKK 318

  Fly   332 INLLYSTPSCYLKSLHDAGITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCK 396
            :.::||||:||.|::.....|...|.||||||||..|:||||||||||..|...|..:..||:.|
Worm   319 VRVIYSTPACYTKAVQAKTPTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGMIRQASCMLQLAK 383

  Fly   397 QLSALAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNALN 461
            ||..:|...||: |..:..:||...::|||||:|||.||.|..||.|:::           ..::
Worm   384 QLDVIANLGPED-DSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLA-----------KGVS 436

  Fly   462 QLTVQSKDNVKDTS-----AKYVFEFKTCALLNITSCPVSEANDRFALTLYNPLAHTVNEYVRIP 521
            ::.|...|.:|..:     .|.|.    |.|:|.|.|.....:..|::.::|......|..:|||
Worm   437 EVEVVINDFMKKMNPDGLDPKLVL----CPLINETICKPINGSSEFSVVIFNSNGRYFNGTIRIP 497

  Fly   522 VPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEI-VFLATNIPALGYRTYYVEKLDST 585
            .......:.|.....||||.|...|  ||.........||| ||:  .:|.|||.|.:|||....
Worm   498 YSQKTAVLRDAHKNVLESQIVETFQ--IDQLKDTDRLPYEIHVFV--RVPPLGYTTVFVEKGSKP 558

  Fly   586 EG---NTRSKALPKRTSSVTVIGNSHIQLGFDTNGFLSEVT--ADGLTRLVSQEFLFYEGAVGNN 645
            |.   |.|     |:.::...|.|.::..|||:.|:||.:|  |....|.:.|||.:|||....:
Worm   559 ERVHFNNR-----KKFNTNVEIQNEYLIAGFDSQGYLSYITEKATKKKRSIRQEFFYYEGIDSKD 618

  Fly   646 AEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEW 710
                ::.||||||||...:....|.::.:||..|.:::||.||.:.::||.:|:....:|.||||
Worm   619 ----DQPSGAYIFRPKTQQPIALTSKLALEVVPGAIINEVRQKVSPFVSQQIRLPRGKNYIEFEW 679

  Fly   711 LVGPIPID--DGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYP 773
            :|||||.:  :.|.||.:||:.:::.|.....||||||:.::|..:...::.....|.:||||||
Worm   680 IVGPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYP 744

  Fly   774 ITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNET-EYGDGLIAR 837
            ||:...::|:.|:.:::||||| |....||.:|:|:|||...||.|||.|||:|. :.|.||:|.
Worm   745 ITSFGYIKDENAQFSVITDRAQ-GMVASDGVVEIMLHRRCFYDDHFGVEEALDEPGKDGAGLVAM 808

  Fly   838 GKHHLFFGKSTDREGVSLKGIERLTQLEKLL------PTWKFFSNMEDYSADEWQTAFTNI--FS 894
            |||.:.|   ||.:..:       :||..|.      |...|..|.|.:.       |..:  :|
Worm   809 GKHIVLF---TDVKAST-------SQLRPLAIDNFHQPVLAFNKNPEKFE-------FNRLLEYS 856

  Fly   895 GISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLD 959
            |:...||..:||||||.||:...|:|||:|....|..|..   :|:..::.:.||:...:|..|.
Worm   857 GLKFELPIGIHLLTLEKWHKKSSLIRFENIYHGEEGNSIK---EFDPTHIFTNFDIVSFKELLLG 918

  Fly   960 GN 961
            .|
Worm   919 AN 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	126/276 (46%)
		Alpha-mann_mid	370..445	CDD:214875	37/74 (50%)
		Glyco_hydro_38C	502..957	CDD:285047	165/471 (35%)
aman-1	NP_508811.1	GH38N_AMII_LAM_like	36..313	CDD:212121	127/279 (46%)
		Alpha-mann_mid	357..431	CDD:286360	37/74 (50%)
		Glyco_hydro_38C	537..944	CDD:285047	149/416 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159877
Domainoid	1	1.000	326	1.000	Domainoid score	I640
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37322
Inparanoid	1	1.050	644	1.000	Inparanoid score	I436
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm14669
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	LDO	PTHR11607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790