Protein Alignment LManII and Man2a1

DIOPT Version :9

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_032575.2
• Gene: Man2a1 / 17158
• MGIID: 104669
• Length: 1150
• Species: Mus musculus
• Alignment Length: 1136
• Identity: 286/1136 - (25%)
• Similarity: 462/1136 - (40%)
• Gaps: 258/1136 - (22%)

  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111
            |.|.:|.|:|:|.|||||.:.|:        :...|||.:::|..|..|..::|::.|.::..||
Mouse   165 LQVFVVPHSHNDPGWLKTFNDYF--------RDKTQYIFNNMVLKLKEDSSRKFMWSEISYLAKW 221

  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVG 176
            |.......:||||.|::.|:||.:.|.|.|.||||.||.::|||...|.:.|....|.  :||.|
Mouse   222 WDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLGV--KPRSG 284

  Fly   177 WQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL- 240
            |.|||||||..||.:..:.||..|...|:.|..|....:.|..|..|..:.:||...|:....:
Mouse   285 WAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMP 349

  Fly   241 YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAKT 285
            :.:|..|.      .|...|.|    |.|..|                ..||:.|....||..:.
Mouse   350 FYSYDIPH------TCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRK 408

  Fly   286 QSQYYRTNNIIVTMGGDF---TYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLH 347
            :|:.:||..::..:|.||   .|....:..:|.::|..|.|.:.  ...:.:.:.|.|.|..:|.
Mouse   409 KSKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQP--HLKVKIQFGTLSDYFDALE 471

  Fly   348 DA--------GITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALAPK 404
            .|        ...:|..|.|||.||.....||:|||||||..||.:|.....::..:.|..||.|
Mouse   472 KAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALK 536

  Fly   405 KPEEF-------DPH---LTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNA 459
            :.:::       .||   ||..|..||:.|||||||||.|:.|.:||..|:..:..:......::
Mouse   537 QAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDS 601

  Fly   460 LNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCP------VSEANDRFALTLYNPLAHTVNEYV 518
            ...|.::.|...:...:|...|..| ...:..|.|      :|....|: |.:|||.....:..|
Mouse   602 AFLLILKDKKLYQSDPSKAFLEMDT-KQSSQDSLPQKIIIQLSAQEPRY-LVVYNPFEQERHSVV 664

  Fly   519 RIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFLATNIPALGYRTYYVEKLD 583
            .|.|..:..:::.:.|..:|   |.:..|..|:: ..|.|.||:.||| :||.||.:.:.:.:..
Mouse   665 SIRVNSATVKVLSDSGKPVE---VQVSAVWNDMR-TISQAAYEVSFLA-HIPPLGLKVFKILESQ 724

  Fly   584 STEGNTRSKALPKR----------------TSSVTVIGNSHIQLGFDTNGFLSEV--TADGLTRL 630
            |:..:.....|...                ......|.|..:.:.||.:|.:.:|  ..|.....
Mouse   725 SSSSHLADYVLYNNDGLAENGIFHVKNMVDAGDAITIENPFLAIWFDRSGLMEKVRRKEDSRQHE 789

  Fly   631 VSQEFLFYEGAVGNNAEFLNRSSGAYIFRPN-ENKIHFATDQVEIEVYKGDLVHEVHQKFNDWIS 694
            :..:||:|  ...|..:    .||||:|.|: :.:.:.:.....:.|.:|.:..:| ..|.:.::
Mouse   790 LKVQFLWY--GTTNKRD----KSGAYLFLPDGQGQPYVSLRPPFVRVTRGRIYSDV-TCFLEHVT 847

  Fly   695 QVVRVYNKDSYAEFEWLVGP-------IPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRK 752
            ..||:||      .:.:.|.       :.|.:...:|::.|.:|.|.:...:.||.||.:
Mouse   848 HKVRLYN------IQGIEGQSMEVSNIVNIRNVHNREIVMRISSKINNQNRYYTDLNGYQ----- 901

  Fly   753 INHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDD 817
            |..|.|.| |:  .:..|.||:.|...::|...|:.:|:.::.|.||:..|.:|:.:.|||::||
Mouse   902 IQPRRTMS-KL--PLQANVYPMCTMAYIQDAEHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDD 963

  Fly   818 AFGVGEALNETEYGDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKLLPTW--KFFSNMEDY 880
            ..|:|:.::     |..|......:...|   |..|::       :.||..|..  ...|:|
Mouse   964 NRGLGQGVH-----DNKITANLFRILLEK---RSAVNM-------EEEKKSPVSYPSLLSHM--- 1010

  Fly   881 SADEWQTAFTN------IFSGISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQF 939
                 .::|.|      :.||   .||.|
Mouse  1011 -----TSSFLNHPFLPMVLSG---QLPSP------------------------------------ 1031

  Fly   940 NVKNVLSAFDVEGIRETTLDGNAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAE--KP 1002
                   ||::             |.|...||               .|.|.: :||::..  :.
Mouse  1032 -------AFEL-------------LSEFPLLQ---------------SSLPCD-IHLVNLRTIQS 1060

  Fly  1003 MLGVKYADEALPAGQLGAESNRIRRETETRQEKKDEGRSSKSTEGP------YNSF--------- 1052
            .:|..|:|||.....        |:..:.:...:..|....:|:|.      :|.|
Mouse  1061 KMGKGYSDEAALILH--------RKGFDCQFSSRGIGLPCSTTQGKMSVLKLFNKFAVESLVPSS 1117

  Fly  1053 ------KSDSSNQEYIIELSPMEIRTFIVYL 1077
                  ..|:.|... :.||||||.||.:.|
Mouse  1118 LSLMHSPPDAQNMSE-VSLSPMEISTFRIRL 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	94/299 (31%)
		Alpha-mann_mid	370..445	CDD:214875	36/84 (43%)
		Glyco_hydro_38C	502..957	CDD:285047	103/488 (21%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	286/1136 (25%)
		GH38N_Man2A1	164..507	CDD:212131	110/359 (31%)
		Alpha-mann_mid	502..587	CDD:214875	36/84 (43%)
		Glyco_hydro_38C	757..1143	CDD:285047	105/513 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840