Protein Alignment LManII and Man2a2

DIOPT Version :9

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_766491.2
• Gene: Man2a2 / 140481
• MGIID: 2150656
• Length: 1152
• Species: Mus musculus
• Alignment Length: 1151
• Identity: 293/1151 - (25%)
• Similarity: 442/1151 - (38%)
• Gaps: 293/1151 - (25%)

  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111
            |.|.:|.|:|:|.||:||.|:||        ....|:|::|:|..|..||.:||::.|.:||.||
Mouse   166 LQVFVVPHSHNDPGWIKTFDKYY--------TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVG 176
            |.....:.:.||:.||..|:||...|.|.|.|||.:||.:::||...|.:.|....|  ..||.|
Mouse   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   177 WQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL- 240
            |.:||||||..|..:..:.....|...|:.|..|.....|.:.|.:|....:.....|:|...:
Mouse   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMP 350

  Fly   241 YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAKT 285
            :.:|..|.      .|...|.|    |.|..|                :.||.:|....||..:.
Mouse   351 FYSYDVPH------TCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRK 409

  Fly   286 QSQYYRTNNIIVTMGGDFTYQAAQVY---YKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLH 347
            :|:.:|:|.::|.:|.||.|...|.:   :.|..:|..:.|.:..  .::...:.|.|.|..:|:
Mouse   410 KSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPE--FHVQAQFGTLSEYFDALY 472

  Fly   348 D-AGIT-------WPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQL------ 398
            . .|:.       :|..|.|||.||.....|||||:||||..|..:|.....|:..:.|
Mouse   473 KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEILYSLALA 537

  Fly   399 ----SALAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNA 459
                |.||.:.|......||..|.|||:.|||||||||.||.|.:||..|:..:..:......||
Mouse   538 HARRSGLAGQYPLSDFALLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINA 602

  Fly   460 LNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVS------------EANDRFALTLYNPLAH 512
            .:.|.:..::.       |.|:..| ..|.:....||            :::.|| :.::|||..
Mouse   603 AHYLVLGDQET-------YSFDPGT-PFLQMDDSRVSHDALPERTVIRLDSSPRF-VVVFNPLEQ 658

  Fly   513 TVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVF---LATNIPALGY 574
            .....|.:.|.....|::..:|..|..|        |.:...::|.....|:   :...:|.||.
Mouse   659 ERLSVVSLLVNSPRVRVLSEEGQPLSVQ--------ISVHWSSATDMVPDVYQVSVPVRLPGLGL 715

  Fly   575 RTYYVE-------KLDSTE---------GNTRSKALPKRT----SSVTVIGNSHIQLGFDTNGFL 619
            ....::       .|.|:.         ..:|..|.|.|.    :|...|.|.::|:.|
Mouse   716 GVLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAFPVRVVDSGASDFAISNRYMQVWF------ 774

  Fly   620 SEVTADGLTRLVSQ--------------EFLFYEGAVGNNAEFLNRSSGAYIFRP-NENKIHFAT 669
                 .|||.|:..              |||.|......:      .||||:|.| :|.|.:...
Mouse   775 -----SGLTGLLKSIRRVDEEQEQQMELEFLVYGTRTSKD------KSGAYLFLPDSEAKPYVPK 828

  Fly   670 DQVEIEVYKGDLVHEV---HQKFNDWISQVVRVYNKDSYAEFEWLVG----------PIPIDDGI 721
            ....:.|.:|....||   ::.|:    ||:|:||         |.|          .:.|.|.:
Mouse   829 KPPVLRVTEGPFFSEVAVYYEHFH----QVIRLYN---------LPGVEGLSLDMSFQVDIRDYV 880

  Fly   722 GKEVITRFNSDIASDGIFRTDSNG-----REMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVE 781
            .||:..|.::||.|.|.|.||.||     |:.:|:.             .:..|:||:.....::
Mouse   881 NKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLKKL-------------PLQANFYPMPVMAYIQ 932

  Fly   782 DDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEYGDGLIARGKHHLFFGK 846
            |...|:.:.|.:|.|.|||.:|.||:::.|||::||..|:|:.|.     |..|...:..|...:
Mouse   933 DSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLK-----DNKITCNRFRLLLER 992

  Fly   847 STDREGVSLKGIERLTQLEKLLP--TWKFFSN---MEDYSADEWQTAFTNIFSGISLVLPKPVHL 906
            .|.......:..||.|....||.  |..:.|.   :...:..:..:.....|..::..||...||
Mouse   993 RTTMSPEVHQEQERSTSYPSLLSHLTSMYLSTPPLVLPVAKRQGTSPALRSFHPLASPLPCDFHL 1057

  Fly   907 LTLE--------PWHENQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLDGNAW 963
            |.|.        |..::.|::.     ..|.|..      ...||:       |...||..|...
Mouse  1058 LNLRMLPAEDTLPATDSALILH-----RKGFDCG------LEAKNL-------GFNCTTSQGKLA 1104

  Fly   964 LDESRRLQFAPDPEEAAFNTY-ATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRIRR 1027
            |.             :.|:.. .||.||.....|.....|
Mouse  1105 LG-------------SLFHGLDVTFLQPTSLTLLYPLASP------------------------- 1131

  Fly  1028 ETETRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTF 1073
                          |.||:                |.|.||||.||
Mouse  1132 --------------SNSTD----------------ISLEPMEISTF 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	92/299 (31%)
		Alpha-mann_mid	370..445	CDD:214875	37/84 (44%)
		Glyco_hydro_38C	502..957	CDD:285047	118/523 (23%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	293/1151 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840