DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManII and man2a2

DIOPT Version :9

Sequence 1:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_009296075.1	Gene:	man2a2 / 100333987	ZFINID:	ZDB-GENE-110331-1	Length:	1174	Species:	Danio rerio

Alignment Length:	889	Identity:	248/889 - (27%)
Similarity:	387/889 - (43%)	Gaps:	180/889 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111
            |.|.:|.|:|:|.||:||.|: ||..:|       |:|::::|..:..||.::||:.|.::|.||
Zfish   166 LQVFVVPHSHNDPGWIKTFDK-YYNDQT-------QHILNNMVTKMAEDPRRKFIWSEISYFAKW 222

  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVG 176
            |:......||.::.|:..|:||.:.|.|.|.|||..||.::|||...|.:.|....|.  .||.|
Zfish   223 WESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGV--TPRSG 285

  Fly   177 WQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL- 240
            |.:||||||..|..:..:.....|...|:.|..|.....|::.|.:|..:.::....|:|...:
Zfish   286 WAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMMP 350

  Fly   241 YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAKT 285
            :.:|..|.      .|...|.|    |.|..|                |.||.||....||..:.
Zfish   351 FYSYDVPH------TCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDANVAERAGVLLDQYRK 409

  Fly   286 QSQYYRTNNIIVTMGGDFTYQAAQVY---YKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLH 347
            :|:.:|:..::|.:|.||.|..|..:   |.|..||..|.|....  .::...::|.|.|..:::
Zfish   410 KSKLFRSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPE--MHVKAQFATLSDYFDAVY 472

  Fly   348 DA-GIT-------WPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALA-- 402
            .| |:|       :|..|.|||.||.....||:||:||||..|..:|.....|:..:.|.:||
Zfish   473 KANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLAVA 537

  Fly   403 --------PKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNA 459
                    .:.|......||..|..:|:.|||||||||.||.|.:||..|:..:.........||
Zfish   538 HARHAGVEGRYPVSDYSLLTDARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIINA 602

  Fly   460 LNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEANDRFA-------------------LT 505
            .:.|.:::||         ::.|       ..:.|..|.:||.|                   |.
Zfish   603 AHFLIIKNKD---------IYRF-------YQTEPFLETDDRRATQDSLPQRTLIELESSPRYLV 651

  Fly   506 LYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAK----YEIVFLA 566
            |:||:.......|.:.|..:..|::...|.||..|        :..:..::|..    |:..|:|
Zfish   652 LFNPVEQERLCLVTVLVNSARVRVLTEDGQTLPVQ--------LSAQWMSATEMSGEVYQASFMA 708

  Fly   567 TNIPALGYRTYYVEKLDSTEGNTRSKAL---PKRTSSV-----------TVIG------NSHIQL 611
             .:||||...:::.....:....||:.|   |.|..|:           ||.|      :..:.|
Zfish   709 -RLPALGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQSLTL 772

  Fly   612 GFD-TNGFLSEVTA--DGLTRLVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVE 673
            ||. ..|.|..:..  |.....|..:||.|......:      .||||:|.|:.|...::..:..
Zfish   773 GFSGATGLLESIRRKDDPQEVRVQIQFLTYGTRPSKD------KSGAYLFLPDGNAKPYSQREAP 831

  Fly   674 I-EVYKGDLVHEV---HQKFNDWISQVVRVYNKDSYAEFEWLVGPIPIDDGI------------- 721
            | .|.:|.|..||   :|.|    .|.||::|             :|..||:
Zfish   832 IVRVVEGPLFAEVVAHYQHF----QQTVRIHN-------------VPGVDGLSLDITTMVDIRDQ 879

  Fly   722 -GKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTA 785
             .||:..||.:||.|...|.||.||.::..|:      :..|:  .:..|:||:.:...::|...
Zfish   880 NNKELAMRFVTDIQSGDTFYTDLNGFQIQPRR------YFQKL--PLQANFYPMPSTAYIQDSQY 936

  Fly   786 RMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETE 829
            |:.:.|.:|.|.:||..|.||:::.|||::||..|:|:.|.:.:
Zfish   937 RLTLHTAQALGVTSLASGQLEVILDRRLMQDDNRGLGQGLKDNK 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	94/299 (31%)
		Alpha-mann_mid	370..445	CDD:214875	33/84 (39%)
		Glyco_hydro_38C	502..957	CDD:285047	96/392 (24%)
man2a2	XP_009296075.1	PLN02701	128..1173	CDD:178304	248/889 (28%)
		CE4_SF	165..508	CDD:301698	111/359 (31%)
		Alpha-mann_mid	503..588	CDD:214875	33/84 (39%)
		Glyco_hydro_38C	741..1169	CDD:285047	72/271 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940