Protein Alignment LManI and AMS1

DIOPT Version :9

• Sequence 1: NP_001260350.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_011359.1
• Gene: AMS1 / 852721
• SGDID: S000003124
• Length: 1083
• Species: Saccharomyces cerevisiae
• Alignment Length: 888
• Identity: 172/888 - (19%)
• Similarity: 293/888 - (32%)
• Gaps: 272/888 - (30%)

  Fly     1 MINVHLVPHSHDDVGWL--------KTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFI- 56
            :.||:.:.:.|.|..||        |.|..  :.||..:.....:|               :|:
Yeast   288 LTNVYGIGNCHIDTAWLWPFAETRRKIVRS--WSSQCTLMDRFPEY---------------KFVA 335

  Fly    57 -QVETFFFAKWYSE-QTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLK 119
             |.:.|   ||..| ..|...:.:...:.|.:....||.|..||......:|:..||..|.|:..
Yeast   336 SQAQQF---KWLLEDHPEFFNKVLIPKIQQSQFFAVGGTWVENDTNIPSGESLARQFFFGQRFFL 397

  Fly   120 DTFGDCGRPTVGWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESL 184
            ..||  .:..:.|..|.||:|.:|..:           .|:..:||     .|..::.|.:..|.
Yeast   398 KHFG--LKSKIFWLPDTFGYSSQMPQL-----------CRLSGIDK-----FLTQKLSWNNINSF 444

  Fly   185 KNS-----NIFTGMLYNHYSAPPGFCFDINCEDAPIIDGESYDNNVDARVSEFIDYVK----NMS 240
            .:|     .|....|..|  .|||                    |.....|.|.|.::    |.:
Yeast   445 PHSTFNWAGIDGSQLLTH--MPPG--------------------NTYTADSHFGDVLRTAKQNKT 487

  Fly   241 KSYRSTHIMV-PMGDDFQYEDAAVNFKNMDKL--IKYVNDRQ-------STGSQVNVFYSTPSCY 295
            ..|..:.:|: ..||.    ......:.:.|:  |:.:|:|.       ..|..|:.||.
Yeast   488 PEYYGSGLMLYGKGDG----GGGPTEEMLQKMRRIRSMNNRNGNVIPKLQVGITVDEFYD----- 543

  Fly   296 LYELHQLKQTWPNKTEDFFPYSSDSH-SYWTGYFTSRPTQKRFHRDGN---HFFQTV-KQLSVLA 355
                ..||:|  |:..|...:|.:.: .:..|.:||:...|:..|...   |..:.: .:.|||.
Yeast   544 ----DILKRT--NQGHDLPTWSGELYFEFHRGTYTSQAQTKKLMRLSEIKLHDLEWIAAKTSVLY 602

  Fly   356 NLSGTQYSEDLDNLSQAMGIMQHHDAVTGT------EKQA------VASDYDRLLFKAIVGAENS 408
            ..|....|:.::.|.:.:.:.|.||.:.|:      :.:|      |..:...|:.|.:...::.
Yeast   603 PDSYKYPSKQINELWENVLLCQFHDVLPGSCIEMVYKYEAVPMLHNVVKECTSLIDKTVQFLQSQ 667

  Fly   409 ARDALRSLTNLT-------------SGEFESCL------------ELNISVCAFTQDTANNVIVT 448
            ::..|..:..||             :|.:.|.:            :|.:.:|..|     .||.:
Yeast   668 SKADLVEMRTLTWSKPEKVSEECSLNGSYTSSVTGYDDYIVLANGKLKVIICKKT-----GVITS 727

  Fly   449 LVNP---LAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALE----------HRPND 500
            :.:.   :.:..|::.|.......:::.|:|         |:.||....|          .:|..
Yeast   728 ITDETLGVEYLDTEHGRNKLGANQFVIYDDK---------PLGWQAWDTELYSVNQYKYVTKPKK 783

  Fly   501 TQ----------HELVFEAS----VDKIANFLIRVLPSPKNIAED---------------QVQFP 536
            .|          .|::|:.|    :..:.:.....:...|....|               :|:||
Yeast   784 VQVSCNTKEKCAVEVIFQISEKCKIKSVISLNATAVTDAKLSKVDISTTVENWDARNKFLKVEFP 848

  Fly   537 VERSQDELTVET--SLVK--LTFDTTTGGLKTVKMNGFTENIQQTFGIYKGYRGNNGESKNRS-- 595
            |....|..:.||  .:.|  ..::|:....|       .|.....|..|..|      ||..|
Yeast   849 VNIRNDFASYETQFGITKRPTHYNTSWDVAK-------FEVCHHKFADYSEY------SKGVSIL 900

  Fly   596 -SGAYVFRPYGDIEIVNNKVELSFYNGTKVKEVH-------------QHVNEWISQVIRIYEDVN 646
             ...|.|..:|      |.:.||.....|..:.|             .|.....|..:::..:.|
Yeast   901 NDCKYGFSTHG------NLMRLSLLRSPKAPDAHADMGTHEIKYAIYPHRGALSSDTVKLAHEFN 959

  Fly   647 RVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMSEAISG 711
            .. |::   .:|      |:|...|...||..|    |.|  .||...:...:      ..|:..
Yeast   960 YC-FKY---KLP------KDIGMNFDDIISISG----DEN--VILSNIKRGED------DSAVKS 1002

  Fly   712 NYYPVTGQISLQD-DEKRITLLNDRAQGGTSLKDGELELMLHR 753
            ||       ||.. ||:.|.:....:.||.|.......|.|.|
Yeast  1003 NY-------SLNPRDEQSIVVRVYESLGGESFASLNTTLNLKR 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	61/296 (21%)
		Alpha-mann_mid	323..398	CDD:286360	18/90 (20%)
		Glyco_hydro_38C	536..941	CDD:285047	52/239 (22%)
AMS1	NP_011359.1	AMS1	44..1083	CDD:223460	172/888 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930