DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and man2b1

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001072469.1	Gene:	man2b1 / 779924	XenbaseID:	XB-GENE-958698	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	975	Identity:	418/975 - (42%)
Similarity:	582/975 - (59%)	Gaps:	54/975 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :||||:||:|:||||||||||||||:.|.|||||||||||:||.:||.|.|:|||.||:.||.:|
Frog    39 LNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQHAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRW 103

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.:|.|.|:|.|.:||.:|||||..|.|||||||..||.|::||..|||::||.||||||||.|.
Frog   104 WKQQDELVRRDVTRLVEEGRLEFINGGWSMNDEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVA 168

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLK--NSNIFTGML 194
            |.|||||||||.|.:||||.::|.||.|:||.||..|....:|||:|::|:.:.  .:::|||:|
Frog   169 WHIDPFGHSREQALLFAQMGYDGFFFGRLDYQDKANREKTKQMEMLWRASDDISPPYADLFTGVL 233

  Fly   195 YNHYSAPPGFCFDINCEDAPIIDGESY-DNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQY 258
            .|.|:.|.|||:|..|:|.||||..|. |.|.|..|.:|:......::.|.|:||::.||.||||
Frog   234 PNGYNPPDGFCWDQLCDDTPIIDDPSVEDYNADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQY 298

  Fly   259 EDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSHSY 323
            |:|.:.|||||:|||.||.:|..||:||||||||||||..||:...|||.|.:|||||:...|.:
Frog   299 ENAIMWFKNMDRLIKNVNMQQINGSKVNVFYSTPSCYLQSLHRANLTWPMKMDDFFPYADGPHMF 363

  Fly   324 WTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGTQ--YSEDLDN-LSQAMGIMQHHDAVTGT 385
            |||||||||..|.:.|..|:|.|...|:..|:.|....  |.:.... :.:|||:.|||||||||
Frog   364 WTGYFTSRPAFKGYERLSNNFLQVCNQMEALSGLEARNGPYGQSSSTVMRRAMGVAQHHDAVTGT 428

  Fly   386 EKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVTLV 450
            .||.|.:||...|.:.....:....::|.|||. |...|..|..||||||..| :||||..|.|.
Frog   429 AKQHVNNDYSLRLSEGWDSCQVVISNSLSSLTG-TKENFAFCNLLNISVCHVT-ETANNFKVYLY 491

  Fly   451 NPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKI- 514
            |||..|.|..||:|.....|.|.......|.||||.|.....||..:....:.||:|:..:..:
Frog   492 NPLGRSVTWTVRLPVNGHAYKVIGPNDETVPSEVVDVSDFTKALRFQQGGAERELIFQGQIPAVG 556

  Fly   515 -ANFLIRVLPSPKNIAEDQVQFPVERSQDEL-TVETSLVKLTFDTTTG---GLKTVKMNGFTENI 574
             ::|.:..|..|     |:.....:|.:.:. .::....::.||..||   |:..::.. .:..:
Frog   557 FSSFTVGKLSLP-----DRFVIKGKRGKKQPDKIQNQYYRVDFDPETGLISGIHNLEKK-ISLPL 615

  Fly   575 QQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDIEI-VNNKVELSFYNGTKVKEVHQHVNEWISQV 638
            :|:|..|....||  |..::.||||:|||.....: |:..|.......:.|:||||:.:.|.|||
Frog   616 KQSFYWYNASVGN--EESSQPSGAYIFRPNNSDSVPVSQHVRSYLVQNSLVQEVHQNFSSWCSQV 678

  Fly   639 IRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTP 703
            :|:|.|...:|.||.|||:|..|:.|||:|:...:|:.:.|.||||||||:||:|.|:.||.:..
Frog   679 VRLYRDQRYIELEWTVGPVPIGDEWGKEVISLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKL 743

  Fly   704 DMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAFGVGEALN 768
            :.:|.|:||||||..:|.::....::|:|.||:|||:|::||.||||:|||||.||..||||.|.
Frog   744 NQTEPIAGNYYPVNSRIYIKGKNTQVTVLTDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLL 808

  Fly   769 ET-QYGTGLIARGKIYLILD----AVDGKPNQRLLQHQLDQHFWKFFSKSNGV----ASVNRNMI 824
            |. ..|.|::.||:..|:||    |.|......|.|:...|   ...|..:|:    :...:...
Frog   809 ENGLLGEGIVVRGRHLLLLDHADEAADTHRTLALQQYMSPQ---VVLSSGDGIPYSQSGTPKRKF 870

  Fly   825 PDFFG-IPESVELLSLEPYSKDQILIRLEN-FNTE-----GNVVSFNIYPLFESLDGYQIWETTL 882
            ....| :|::..||:...::.|:||:|||: |.::     ...::.|:..||.|:......||||
Frog   871 SALNGELPQNGHLLTFAMHAADKILLRLEHPFQSQESKNNSQPITINLNTLFSSVSLSNFEETTL 935

  Fly   883 DGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRTFIIQQKY 947
            ..||....:||.:: :..||| |..::   :|..|:...|.       :||.||:||||:...:|
Frog   936 GANMEKSRLKRLQW-RTRTGS-PLQMD---SPRAPVVDPSN-------ITLSPMEIRTFLANVRY 988

Fly 948 947
Frog 989 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	158/276 (57%)
		Alpha-mann_mid	323..398	CDD:286360	35/77 (45%)
		Glyco_hydro_38C	536..941	CDD:285047	147/425 (35%)
man2b1	NP_001072469.1	PLN02701	39..987	CDD:178304	417/972 (43%)
man2b1	NP_001072469.1	GH38N_AMII_LAM_like	39..317	CDD:212121	159/277 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I465
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm47730
Panther	1	1.100	-	-	O	PTHR11607
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160