DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and man2b1

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_005169420.1	Gene:	man2b1 / 541519	ZFINID:	ZDB-GENE-050327-52	Length:	984	Species:	Danio rerio

Alignment Length:	986	Identity:	430/986 - (43%)
Similarity:	603/986 - (61%)	Gaps:	82/986 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAK 65
            |:|||||||:|||||||||||||:||.:|.|||||||||||:|:::|.||.:||||.|||.||.:
Zfish    43 MLNVHLVPHTHDDVGWLKTVDQYFYGDRNNIQHAGVQYILDSVIDQLQKDPARRFIYVETAFFYR 107

  Fly    66 WYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            |:.:|.:..:|.|.:||.:|||||..|.|.|:||||.||.:|:||..||||:|.||||:||||.|
Zfish   108 WWRQQNQNTRRIVTQLVNEGRLEFINGGWCMSDEATTHYSAVIDQMTLGLRFLNDTFGECGRPRV 172

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKN--SNIFTGM 193
            .|.||||||:||.|||||||.::|.||.|:||.||.:||...||||:|::||||..  :::|||:
Zfish   173 AWHIDPFGHAREHASIFAQMGYDGFFFGRLDYQDKDRRMKTKEMEMLWRASESLTPPIADLFTGV 237

  Fly   194 LYNHYSAPPGFCFDINCEDAPIIDG-ESYDNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQ 257
            |.|.|:.|.|||:|.:|:||||.|. :..|.|||..|.:|::.....:..|::.||::.||.|||
Zfish   238 LPNGYNPPEGFCWDQSCDDAPIRDDPDLEDYNVDEIVQKFLNASHKQADYYKTNHIIMTMGSDFQ 302

  Fly   258 YEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSHS 322
            ||:|.:.:|||||||||||..|:.||::||.||||||||.||:....|||.||:|||||:.|:|.
Zfish   303 YENANLWYKNMDKLIKYVNALQAKGSKLNVLYSTPSCYLQELNLANFTWPMKTDDFFPYADDAHD 367

  Fly   323 YWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGTQ--YSE-DLDNLSQAMGIMQHHDAVTG 384
            :|||||||||..|.:.|..|...||..||.||...:.|.  :.| |.|.:.:|||:.||||||:|
Zfish   368 FWTGYFTSRPALKLYERLSNSRLQTCNQLEVLGGPTSTSGPFGEGDSDTMRRAMGVAQHHDAVSG 432

  Fly   385 TEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVTL 449
            ||||.||:||.|.|.......|....::|..|:. :......|..||||||..| ::::...:.:
Zfish   433 TEKQHVANDYARRLATGWAHCEVLVSNSLAVLSG-SEAPRVFCENLNISVCPLT-ESSHKFSMNV 495

  Fly   450 VNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKI 514
            .|||..:....||:|.....|.|||..|:.|.|||:|:......:.......:.||||:.....:
Zfish   496 YNPLGRTVRWPVRLPVNGSVYNVTDANGKAVDSEVIPLSKSRKEVRQNRGFAKSELVFQVEAPPL 560

  Fly   515 --ANFLIRVLPSPKNIAEDQVQFPVERSQDEL--TVETSLVKLTFDTTTG------GLKTVKMNG 569
              :.::|.::         |.|.||.||::.:  :::...:|:|||:|||      .|:|.:
Zfish   561 GYSTYIISMV---------QDQPPVSRSKNAVPSSIQNKFLKVTFDSTTGLLSSLTNLETQQ--- 613

  Fly   570 FTENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP-YGDIEIVNNKVEL---SFYNGTKVKEVHQH 630
             |..:.|.|..|....|||.|| ::.||||:||| ..|..|::...|:   |.||  .|:||.|.
Zfish   614 -TIRLTQNFFWYNASAGNNKES-HQPSGAYIFRPNSSDPFIISKTAEIQAVSLYN--SVQEVTQR 674

  Fly   631 VNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERER 695
            .:.|:|||:|:|||...:|.||.|||:|.:|.:|||:|||..::|.|.|.|||||||||:|||.:
Zfish   675 FSPWVSQVVRLYEDRRELELEWTVGPVPVEDGLGKEVITRLDTDIQSSGYFYTDSNGREVLERRK 739

  Fly   696 NQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDA 760
            :.|..:....:|.|:|||||:..:..::||::::|::.||:||.:|:.:|.||:|||||||.||.
Zfish   740 DYRPTWDLKQTEPIAGNYYPINSRAYIKDDKRQLTVVTDRSQGASSIYNGSLEIMLHRRLLYDDF 804

  Fly   761 FGVGEALNET-QYGTGLIARGKIYLILDAVDGKP--NQRLLQHQLDQHFWKFFSKSNGVASVNRN 822
            .||||.|:|. ::..||:|||::.|.|...:...  ::.|.|..:.|....|   .:|..|....
Zfish   805 RGVGEPLSEPGEFAHGLVARGRLLLTLSPPEAAADLHRPLAQSMVLQPLLSF---QDGAPSPGTK 866

  Fly   823 MIPDFFG----IPESVELLSLEPYSKDQILIRLEN------FNTEGNVVSFNIYPLFESLDGYQI 877
            :  :|.|    :|.:|.||::..:.:|.:|:|||:      ..|....|:.|:..||.:|.....
Zfish   867 L--EFSGLQAALPPAVHLLTVSQWDQDSVLVRLEHQYQAKESKTHSQPVTVNLQKLFSTLQVLGA 929

  Fly   878 WETTLDGNMLLEDVKRF-----KFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQ 937
            .|.:|..|...||:.|.     |.|...|...|||.|                     |||.||:
Zfish   930 SEMSLGANQWKEDMIRLHWNTEKDALPPTARDPSSWE---------------------VTLKPME 973

  Fly   938 IRTFIIQQKYI 948
            ||||:::.:.:
Zfish   974 IRTFLLRVRLL 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	162/276 (59%)
		Alpha-mann_mid	323..398	CDD:286360	41/77 (53%)
		Glyco_hydro_38C	536..941	CDD:285047	160/434 (37%)
man2b1	XP_005169420.1	PLN02701	44..982	CDD:178304	429/981 (44%)
		GH38N_AMII_LAM_like	44..322	CDD:212121	163/277 (59%)
		Alpha-mann_mid	368..446	CDD:214875	41/77 (53%)
		Glyco_hydro_38C	558..977	CDD:285047	163/460 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581808
Domainoid	1	1.000	200	1.000	Domainoid score	I2989
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.720