DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and man2a2

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001006777.1	Gene:	man2a2 / 448465	XenbaseID:	XB-GENE-981388	Length:	909	Species:	Xenopus tropicalis

Alignment Length:	786	Identity:	242/786 - (30%)
Similarity:	359/786 - (45%)	Gaps:	141/786 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.||:||.|:|||..        .|:||:.:|.:|.:|..|:||..|..||:||
Frog   166 LQVFVVPHSHNDPGWIKTFDKYYYDQ--------TQHILNNMVVKLHEDPRRKFIWSEISFFSKW 222

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.......:.||::|||.|:||...|.|.|.|||..||.:::||...|.::||....  ..|..|
Frog   223 WDNINSQKRAAVRRLVASGQLEMTTGGWVMPDEANTHYFAMIDQMIEGHQWLKKNLD--ATPRSG 285

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIW-QSSESLKNSNIFTGML- 194
            |.:||||||..|..|..:.........|:.|..||.......:|.:| |:.:...:::||..|:
Frog   286 WAVDPFGHSSTMPYILRRSNLTSMLIQRVHYSIKKHFAATQSLEFMWRQTWDPDSSTDIFCHMMP 350

  Fly   195 YNHYSAP------PGFC--FD--------INCEDAP--IIDGESYDNNVDARVSEFIDYVKNMSK 241
            :..|..|      |..|  ||        |||   |  :......|:||..|.:..:|..|..||
Frog   351 FYSYDVPHTCGPDPKICCQFDFRRLPGGRINC---PWKVPPRAITDSNVAERANILLDQYKKKSK 412

  Fly   242 SYRSTHIMVPMGDDFQYE-----DAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQ 301
            .|||..::||:||||:|:     ||  .|.|..||..|:|.....  .|...:.|.|.|...|::
Frog   413 LYRSKVVLVPLGDDFRYDKIQEWDA--QFLNYQKLFDYMNSHPEL--HVQAQFGTLSDYFDALYK 473

  Fly   302 -------LK-QTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVL---- 354
                   :| ..:|..:.|||.|:.....|||||:||||..|...|......:..:.|..|
Frog   474 RMGVVPGIKPPDFPVVSGDFFSYADREDHYWTGYYTSRPFYKSMDRVLESHLRGAEILYSLAINH 538

  Fly   355 ANLSGTQYSEDLDN---LSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDAL 413
            |..:||:....|.:   |:.|   :|:.|||||:|||.|:||..||...|..:::   |..|..:
Frog   539 ARKAGTESKYPLSDYALLTDARRNLGLFQHHDAITGTAKEAVVIDYGVRLLHSLM---NLKRIII 600

  Fly   414 RSLTNLTSGEFESCLELNISVCAFTQD-----------------TANNVIVTLVNPLAHSSTQYV 461
            .:...|...:.|. ...:.||..|:.|                 ||:...|.:.||:..:....|
Frog   601 NAAHYLVVADKEK-YHYDHSVPFFSTDESRLTQESLPEKTVIKLTASPRYVVVFNPVEQNRLCVV 664

  Fly   462 RVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHEL----------VFE--ASVDK- 513
            .:.....|..|..|.|:.|.:::.|| ||.:. :..|:..|...          :|:  ||:|.
Frog   665 SLLVNTYNVRVLTEDGQPVAAQLSPV-WQSVT-DMNPDVYQVSFTARLPSLGLSIFQLHASIDTH 727

  Fly   514 ---IANFLIRVLPSPKNIAEDQVQFPV---ERSQDELTVETSLVKLTFDTTTGGLKTVKMNG--F 570
               .:|..:.:.....:|.:..| |||   |.|.|:..:|...:::.|..|||.||::|..|  .
Frog   728 TTLKSNVRVHLHGRELSIKKQDV-FPVKVAESSTDDFHIENQYMQVWFSGTTGLLKSIKRAGEEQ 791

  Fly   571 TENIQQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDIEIVNNK-------VELSFYNGTKVKEVH 628
            .:.|...|.|| |.|    .||:: ||||:|.|.|:.:....|       .|..||  ::|...:
Frog   792 EQKINMQFLIY-GTR----TSKDK-SGAYLFLPDGEAKPYTPKDPPVVKVTEGPFY--SEVTCQY 848

  Fly   629 QHVNEWISQVIRIYE---------DVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTD 684
            |||    .||:|:|.         |::.:        |...|.|.|||..|.|::|.|:..|:||
Frog   849 QHV----QQVMRLYNLPGTEGLSLDISSL--------IDIRDHVNKEIAMRLSTDIQSEDIFFTD 901

  Fly   685 SNGREI 690
            .||.::
Frog   902 LNGFQV 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	106/298 (36%)
		Alpha-mann_mid	323..398	CDD:286360	33/84 (39%)
		Glyco_hydro_38C	536..941	CDD:285047	57/176 (32%)
man2a2	NP_001006777.1	PLN02701	128..>906	CDD:178304	242/783 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910