DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and MAN2B1

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_005259970.1	Gene:	MAN2B1 / 4125	HGNCID:	6826	Length:	1012	Species:	Homo sapiens

Alignment Length:	989	Identity:	423/989 - (42%)
Similarity:	574/989 - (58%)	Gaps:	81/989 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAK 65
            |:||||:||:|||||||||||||:||.:|.|||||||||||:|:..||.|.:||||.||..||::
Human    62 MLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSR 126

  Fly    66 WYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            |:.:||...|..|:.||.|||||||.|.|.|||||..||.::|||..||||:|:||||:.|||.|
Human   127 WWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRV 191

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLK--NSNIFTGM 193
            .|.|||||||||.||:||||.|:|.||.|:||.||..||..||||.:|::|.|||  .:::|||:
Human   192 AWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGV 256

  Fly   194 LYNHYSAPPGFCFDINCEDAPII-DGESYDNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQ 257
            |.|.|:.|...|:|:.|.|.|:: |..|.:.|....|..|::......:.||:.|.::.||.|||
Human   257 LPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQ 321

  Fly   258 YEDAAVNFKNMDKLIKYVN-DRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSH 321
            ||:|.:.|||:||||:.|| .:|:.||.|:|.||||:|||:||::...||..|.:|||||:...|
Human   322 YENANMWFKNLDKLIRLVNAQQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPH 386

  Fly   322 SYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLS---GTQYSEDLDNLSQAMGIMQHHDAVT 383
            .:|||||:|||..||:.|...:|.|...||..|..|:   |...|.|...|::||.::||||||:
Human   387 QFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVS 451

  Fly   384 GTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVT 448
            ||.:|.||:||.|.|.......|....:||..|... ...|..|.:||||:|..:| ||....|.
Human   452 GTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGF-KDHFTFCQQLNISICPLSQ-TAARFQVI 514

  Fly   449 LVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQ-H--ELVFEAS 510
            :.|||.......||:|.....::|.|..||.|.|:||..|         .:|:| |  ||:|.||
Human   515 VYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFP---------SSDSQAHPPELLFSAS 570

  Fly   511 VDKI--ANFLIRVLPSPKNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGL-KTVKMN-GFT 571
            :..:  :.:.:..:|..|..|......|.......||:|...::.|||..||.| :.:.|| ...
Human   571 LPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLL 635

  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------YGDIEIVNNKVELSFYNGTKVKE 626
            ..::|||..|....|:|  ..:::||||:|||          :..|.:|...:         |:|
Human   636 LPVRQTFFWYNASIGDN--ESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPL---------VQE 689

  Fly   627 VHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREIL 691
            |||:.:.|.|||:|:|.....:|.||.|||||..|..|||:|:||.:.:.:||:|||||||||||
Human   690 VHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREIL 754

  Fly   692 ERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLL 756
            ||.|:.|..:..:.:|.::||||||..:|.:.|...::|:|.||:|||:||:||.||||:|||||
Human   755 ERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLL 819

  Fly   757 NDDAFGVGEALNETQYGTGLIARGKIYLILD-AVDGKPNQRLLQHQLDQHFWKFFSKSNGVASVN 820
            .||..||.|.|.|.  |:|...||:..::|| |.......|||..| :....:......|.|:.|
Human   820 KDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQ-EVLAPQVVLAPGGGAAYN 881

  Fly   821 RNMIP--DFFG----IPESVELLSLEPYSKDQILIRLENFNTEGN--------VVSFNIYPLFES 871
            ....|  .|.|    :|.||.||:|..:..:.:|:|||:....|.        .|:.|:..||.:
Human   882 LGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFST 946

  Fly   872 LDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPM 936
            ....::.||||..|.|.|...|.|:..: ||..|....|...|.|              :||.||
Human   947 FTITRLQETTLVANQLREAASRLKWTTN-TGPTPHQTPYQLDPAN--------------ITLEPM 996

  Fly   937 QIRTFI--IQQKYI 948
            :||||:  :|.|.:
Human   997 EIRTFLASVQWKEV 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	155/276 (56%)
		Alpha-mann_mid	323..398	CDD:286360	37/77 (48%)
		Glyco_hydro_38C	536..941	CDD:285047	159/431 (37%)
MAN2B1	XP_005259970.1	PLN02701	63..1001	CDD:178304	418/977 (43%)
		GH38N_AMII_LAM_like	63..341	CDD:212121	156/277 (56%)
		Alpha-mann_mid	388..466	CDD:214875	37/77 (48%)
		Glyco_hydro_38C	511..1001	CDD:285047	186/527 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I684
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	811	1.000	Inparanoid score	I487
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm40555
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790