Protein Alignment LManI and MAN2B1

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001427499.1
• Gene: MAN2B1 / 4125
• HGNCID: 6826
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 989
• Identity: 423/989 - (42%)
• Similarity: 574/989 - (58%)
• Gaps: 81/989 - (8%)

  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAK 65
            |:||||:||:|||||||||||||:||.:|.|||||||||||:|:..||.|.:||||.||..||::
Human    62 MLNVHLLPHTHDDVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSR 126

  Fly    66 WYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            |:.:||...|..|:.||.|||||||.|.|.|||||..||.::|||..||||:|:||||:.|||.|
Human   127 WWHQQTNATQEVVRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRV 191

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLK--NSNIFTGM 193
            .|.|||||||||.||:||||.|:|.||.|:||.||..||..||||.:|::|.|||  .:::|||:
Human   192 AWHIDPFGHSREQASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGV 256

  Fly   194 LYNHYSAPPGFCFDINCEDAPII-DGESYDNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQ 257
            |.|.|:.|...|:|:.|.|.|:: |..|.:.|....|..|::......:.||:.|.::.||.|||
Human   257 LPNGYNPPRNLCWDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQ 321

  Fly   258 YEDAAVNFKNMDKLIKYVN-DRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSH 321
            ||:|.:.|||:||||:.|| .:|:.||.|:|.||||:|||:||::...||..|.:|||||:...|
Human   322 YENANMWFKNLDKLIRLVNAQQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPH 386

  Fly   322 SYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLS---GTQYSEDLDNLSQAMGIMQHHDAVT 383
            .:|||||:|||..||:.|...:|.|...||..|..|:   |...|.|...|::||.::||||||:
Human   387 QFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVS 451

  Fly   384 GTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVT 448
            ||.:|.||:||.|.|.......|....:||..|... ...|..|.:||||:|..:| ||....|.
Human   452 GTSRQHVANDYARQLAAGWGPCEVLLSNALARLRGF-KDHFTFCQQLNISICPLSQ-TAARFQVI 514

  Fly   449 LVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQ-H--ELVFEAS 510
            :.|||.......||:|.....::|.|..||.|.|:||..|         .:|:| |  ||:|.||
Human   515 VYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFP---------SSDSQAHPPELLFSAS 570

  Fly   511 VDKI--ANFLIRVLPSPKNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGL-KTVKMN-GFT 571
            :..:  :.:.:..:|..|..|......|.......||:|...::.|||..||.| :.:.|| ...
Human   571 LPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLL 635

  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------YGDIEIVNNKVELSFYNGTKVKE 626
            ..::|||..|....|:|  ..:::||||:|||          :..|.:|...:         |:|
Human   636 LPVRQTFFWYNASIGDN--ESDQASGAYIFRPNQQKPLPVSRWAQIHLVKTPL---------VQE 689

  Fly   627 VHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREIL 691
            |||:.:.|.|||:|:|.....:|.||.|||||..|..|||:|:||.:.:.:||:|||||||||||
Human   690 VHQNFSAWCSQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREIL 754

  Fly   692 ERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLL 756
            ||.|:.|..:..:.:|.::||||||..:|.:.|...::|:|.||:|||:||:||.||||:|||||
Human   755 ERRRDYRPTWKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLL 819

  Fly   757 NDDAFGVGEALNETQYGTGLIARGKIYLILD-AVDGKPNQRLLQHQLDQHFWKFFSKSNGVASVN 820
            .||..||.|.|.|.  |:|...||:..::|| |.......|||..| :....:......|.|:.|
Human   820 KDDGRGVSEPLMEN--GSGAWVRGRHLVLLDTAQAAAAGHRLLAEQ-EVLAPQVVLAPGGGAAYN 881

  Fly   821 RNMIP--DFFG----IPESVELLSLEPYSKDQILIRLENFNTEGN--------VVSFNIYPLFES 871
            ....|  .|.|    :|.||.||:|..:..:.:|:|||:....|.        .|:.|:..||.:
Human   882 LGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFST 946

  Fly   872 LDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPM 936
            ....::.||||..|.|.|...|.|:..: ||..|....|...|.|              :||.||
Human   947 FTITRLQETTLVANQLREAASRLKWTTN-TGPTPHQTPYQLDPAN--------------ITLEPM 996

  Fly   937 QIRTFI--IQQKYI 948
            :||||:  :|.|.:
Human   997 EIRTFLASVQWKEV 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	155/276 (56%)
		PLN02701	4..765	CDD:178304	361/784 (46%)
MAN2B1	NP_001427499.1	None