Protein Alignment LManI and MAN2A1

DIOPT Version :9

• Sequence 1: NP_001260350.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_002363.2
• Gene: MAN2A1 / 4124
• HGNCID: 6824
• Length: 1144
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 286/1076 - (26%)
• Similarity: 464/1076 - (43%)
• Gaps: 232/1076 - (21%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.|||||.:.|:   ::|     .|||.:.:|.:|.:||.|:||..|..:.:||
Human   166 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSRRKFIWSEISYLSKW 222

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.......:.|||.|:..|:||...|.|.|.||||.||.:::||...|.::|::..|  .:|..|
Human   223 WDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIG--VKPRSG 285

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKN-SNIFTGML- 194
            |.|||||||..||.:..:...:.....|:.|..||...|...:|..|:.:..|.: ::|...|:
Human   286 WAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMP 350

  Fly   195 YNHYSAP------PGFCFDINCEDAP---------IIDGESYDNNVDARVSEFIDYVKNMSKSYR 244
            :..|..|      |..|...:.:..|         :.....:..||.:|....:|..:..||.:|
Human   351 FYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFR 415

  Fly   245 STHIMVPMGDDF---QYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQT- 305
            :..::.|:||||   :|.:..:.|||..:|..|:|.:..  .:|.:.:.|.|.:...|.:..:|
Human   416 TKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSK--FKVKIQFGTLSDFFDALDKADETQ 478

  Fly   306 -------WPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLA-------- 355
                   :|..:.|||.|:.....||:|||||||..||..|......:..:.|...|
Human   479 RDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYK 543

  Fly   356 ---NLSGTQYSEDLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAE----NSA---- 409
               .||.:.|:. |....:.:|:.|||||:|||.|..|..||...||.:::..|    |||
Human   544 INKFLSSSLYTA-LTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLI 607

  Fly   410 -RDALRSLTNLTSGEFESCLELNISVCAFTQDT--ANNVI--------VTLVNPLAHSSTQYVRV 463
             :|      .||...:.....|.:.:...:||:  ..|:|        :.:.|||.......|.|
Human   608 LKD------KLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSV 666

  Fly   464 PAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPN---DTQHELVFEASVDKIANFLIRVLPSP 525
            ...:....|....|:       ||..||.|:....|   :|.:|:.|.|.:..:...:.::|.|.
Human   667 YVSSPTVQVFSASGK-------PVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESA 724

  Fly   526 ------------KNIAEDQVQFPVE---RSQDELTVETSLVKLTFDTTTGGLKTV--KMNGFTEN 573
                        ||..||...|.::   .:::.:|:|.|.|.|.|| .||.:|.:  |.:|....
Human   725 SSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFD-QTGLMKQMMTKEDGKHHE 788

  Fly   574 IQQTFGIYKGYRGNNGES-KNRSSGAYVFRPYGD--------------------------IEIVN 611
            :...|..|       |.: |...||||:|.|.|:                          .:.|.
Human   789 VNVQFSWY-------GTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVT 846

  Fly   612 NKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNIS 676
            ::|.|....|.:.:.|.      :|.::.|.:..||                  ||..:.||:|.
Human   847 HRVRLYHIQGIEGQSVE------VSNIVDIRKVYNR------------------EIAMKISSDIK 887

  Fly   677 SKGKFYTDSNGREILERERNQREHFTPDMSEA---ISGNYYPVTGQISLQDDEKRITLLNDRAQG 738
            |:.:||||.||.:|           .|.|:.:   :..|.||:|....:||.:.|:|||:.::.|
Human   888 SQNRFYTDLNGYQI-----------QPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLG 941

  Fly   739 GTSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILD---AVDGKPNQR---- 796
            .:||..|::|:::.|||:.||..|:.:.:.:.:....|..     ::|:   ||:.:..::
Human   942 VSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFR-----ILLEKRSAVNTEEEKKSVSY 1001

  Fly   797 --LLQH---QLDQHFWKFFSKSNGVASVNRNMIPDF----FGIPESVELLSLEP--------YSK 844
              ||.|   .|..|  .....:|..:|....:..:|    ..:|..:.|::|..        :|.
Human  1002 PSLLSHITSSLMNH--PVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSN 1064

  Fly   845 DQILIRLENFNTEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVE 909
            :..||    .:.:|....|       |..|..::.:|..|.:|::.:.. ||..:..  .|||:.
Human  1065 EAALI----LHRKGFDCRF-------SSKGTGLFCSTTQGKILVQKLLN-KFIVESL--TPSSLS 1115

  Fly   910 YYHAPHNPLTAN-STMNASGFVVTLVPMQIRTFIIQ 944
            ..|:|  |.|.| |.:|.|       ||:|.||.||
Human  1116 LMHSP--PGTQNISEINLS-------PMEISTFRIQ 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	93/293 (32%)
		Alpha-mann_mid	323..398	CDD:286360	31/85 (36%)
		Glyco_hydro_38C	536..941	CDD:285047	109/464 (23%)
MAN2A1	NP_002363.2	PLN02701	128..1144	CDD:178304	286/1076 (27%)
		GH38N_Man2A1	165..508	CDD:212131	107/353 (30%)
		Alpha-mann_mid	503..588	CDD:214875	31/85 (36%)
		Glyco_hydro_38C	754..1139	CDD:285047	109/457 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810