DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and alpha-Man-IIa

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	231/856 - (26%)
Similarity:	381/856 - (44%)	Gaps:	144/856 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.||::|.::||       || ..::||...:..|..:...:||..|..:||::
  Fly   145 LKVFVVPHSHNDPGWIQTFEEYY-------QH-DTKHILSNALRHLHDNPEMKFIWAEISYFARF 201

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            |.:..|..:..:|.:|..|:|||..|.|.|.|||..|:::|:.|...|..:||....  ..||..
  Fly   202 YHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMN--VTPTAS 264

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIW-QSSESLKNSNIFTGML- 194
            |.|||||||..|..|..:..|......|..|..||:.....::|.:| |..::..::.:||.|:
  Fly   265 WAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMP 329

  Fly   195 YNHYSAP------PGFC----------FDINCEDAP--IIDGESYDNNVDARVSEFIDYVKNMSK 241
            :..|..|      |..|          |.::|   |  :......|.||.||....:|..|..::
  Fly   330 FYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSC---PWKVPPRTISDQNVAARSDLLVDQWKKKAE 391

  Fly   242 SYRSTHIMVPMGDDFQYEDAA---VNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLK 303
            .||:..:::|:||||:::...   |...|.::|.:::|.:.....|..  :.|...|...:||.:
  Fly   392 LYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQ--FGTLQEYFDAVHQAE 454

  Fly   304 QT----WPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSG-TQYS 363
            :.    :|..:.|||.|:..|.:||:||:||||..||..|...|:.:..:.||...:..| .:..
  Fly   455 RAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIE 519

  Fly   364 EDLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDAL-RSLT--NLTSGEFE 425
            |.|:...:.:.:.||||.:|||.|..|..||::.:.:|:...:...:.:: |.||  ::.|.:|
  Fly   520 ERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDF- 583

  Fly   426 SCLELNISVCAFT-----------QDTANNVI----------VTLVNPLAHSSTQYVRVPAKNEN 469
                   |...||           :|:...:|          |.:.|.|.|...|.|.....:..
  Fly   584 -------SFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPF 641

  Fly   470 YIVTDEKGREVFSEVVPV-PWQ----VLALEHRPNDTQHELVFEASVDKI--------------- 514
            ..|||.....|.::|.|| .|.    ...:..:.:.|::.::|:|.|..:
  Fly   642 VSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPE 706

  Fly   515 -----ANFLIRVLPS--PKNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTVKMNGFTE 572
                 :|.|:|..|:  |.....:.|:|...|   |:::..........:..|.||::::...:.
  Fly   707 HTSYASNLLLRKNPTSLPLGQYPEDVKFGDPR---EISLRVGNGPTLAFSEQGLLKSIQLTQDSP 768

  Fly   573 NIQQTFGIYK-GYRGNNGESKNRSSGAYVFRPYGD----------IEIVNNKVELSFYNGTKVKE 626
            ::...|...| |.|     |....||||:|.|.|.          :.:...|:|.|...|.. ..
  Fly   769 HVPVHFKFLKYGVR-----SHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLP-SV 827

  Fly   627 VHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREIL 691
            |||.:....:..||...|:..::              ..||:.|..::|.|...||||.||.:.:
  Fly   828 VHQTIMRGGAPEIRNLVDIGSLD--------------NTEIVMRLETHIDSGDIFYTDLNGLQFI 878

  Fly   692 ERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLL 756
            :|.|..:   .|     :..||||:...:.::|...|:|||..:..||:||..||||:|..|||.
  Fly   879 KRRRLDK---LP-----LQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLA 935

  Fly   757 NDDAFGVGEAL 767
            :||..|:|:.:
  Fly   936 SDDERGLGQGV 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	89/296 (30%)
		Alpha-mann_mid	323..398	CDD:286360	28/75 (37%)
		Glyco_hydro_38C	536..941	CDD:285047	66/243 (27%)
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	104/352 (30%)
		Alpha-mann_mid	478..554	CDD:214875	28/75 (37%)
		Glyco_hydro_38C	744..1103	CDD:285047	64/231 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450142
Domainoid	1	1.000	50	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I462
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.790