DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and Man2b1

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_006255335.1	Gene:	Man2b1 / 361378	RGDID:	3039	Length:	1021	Species:	Rattus norvegicus

Alignment Length:	985	Identity:	409/985 - (41%)
Similarity:	574/985 - (58%)	Gaps:	77/985 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGS-----------QNKIQHAGVQYILDTVVEELLKDSSRR 54
            |:||||:||:||||||||||||||||.           .:.:|||.||||||:|:..||.|.:||
  Rat    62 MLNVHLLPHTHDDVGWLKTVDQYYYGMDPHLLTFMPIVMSDVQHASVQYILDSVIYSLLNDPTRR 126

  Fly    55 FIQVETFFFAKWYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLK 119
            ||.||..||::|:.:||...|.||:.||.||||||..|.|.|||||..||.::|||..||||:|:
  Rat   127 FIYVEMAFFSRWWKQQTNVTQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQ 191

  Fly   120 DTFGDCGRPTVGWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESL 184
            ||||..|.|.|.|.|||||||||.||:||||.|:|.|..|:||.||..|...|:||.:|::|.||
  Rat   192 DTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKFNRKRKLKMEELWRASASL 256

  Fly   185 K--NSNIFTGMLYNHYSAPPGFCFDINCEDAPIIDG-ESYDNNVDARVSEFIDYVKNMSKSYRST 246
            |  .:::|||:|.|:|:.|...|:|:.|.|.|::|. .|.:.|.:..|..|::...:..|.||:.
  Rat   257 KPPAADLFTGVLPNNYNPPKDLCWDVLCTDPPVVDDPTSPEFNANKLVDYFLNLASSQKKYYRTN 321

  Fly   247 HIMVPMGDDFQYEDAAVNFKNMDKLIKYVND-RQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKT 310
            |.::.||.|||||:|.:.||||||||:.||: :|:.||:|:|.||||||||:||::...||..|.
  Rat   322 HTVMTMGSDFQYENANMWFKNMDKLIRLVNEQQQANGSKVHVLYSTPSCYLWELNKANLTWTVKE 386

  Fly   311 EDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLS---GTQYSEDLDNLSQA 372
            :|||||:...|.:|||||:|||..||:.|...:|.|...||..|....   |...|.|...|::|
  Rat   387 DDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEAKVGPYGSGDSAPLNEA 451

  Fly   373 MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAF 437
            |.::|||||||||.:|.|.:||.:.|.......|....:||..| :|....|..|.|:|||:|..
  Rat   452 MAVLQHHDAVTGTARQNVVNDYAKQLAAGWGPCEVLVSNALARL-SLYKQNFSFCREINISICPA 515

  Fly   438 TQDTANNVIVTLVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQ 502
            :| |:.:..|.:.||:.......||:|.....::|.|...|.:.|.||.||      .......|
  Rat   516 SQ-TSEHFRVIIYNPVGRKVDLMVRLPVSEGIFLVKDPNDRRISSNVVMVP------SAYSKTYQ 573

  Fly   503 HELVFEASVDKI--ANFLIRVLPSPKNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTV 565
            .||:|.|||..:  :.:.:..:....:.|.:....|.:.....|.:|...::.|||:.||.|:.:
  Rat   574 WELLFPASVPALGFSIYSVNKMSGHNHQAHNLTARPKKSKSRVLVIENKYIRATFDSDTGLLRKI 638

  Fly   566 KMNGFTENIQQTFGI-----YKGYRGNNGESKN-RSSGAYVFRPYGDIEI-VNNKVELSFYNGTK 623
                  ||::|...:     :..|..:.|:.:: ::||||:|||.....: |::..:::......
  Rat   639 ------ENLEQNISLPVRQGFFWYNASAGDEESPQASGAYIFRPSHRKPLPVSHWAQVTLVKTNL 697

  Fly   624 VKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGR 688
            |:||||:.:.|.|||||:||....:|.||.|||||..||.|||:|:||::.:.::|:|:||||||
  Rat   698 VQEVHQNFSAWCSQVIRLYEGQRHLELEWTVGPIPVKDDWGKEVISRFNTPMRTRGQFFTDSNGR 762

  Fly   689 EILERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHR 753
            |||:|..:.|..:|.:.:|.::||||||..:|.:.|...::|:|.||:|||:||.||.||||:||
  Rat   763 EILKRRDDFRPTWTLNQTEPVAGNYYPVNTRIYITDGHMQLTVLTDRSQGGSSLLDGSLELMVHR 827

  Fly   754 RLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAV-DGKPNQRLLQHQLDQHFWKFFSKSNGVA 817
            |||.||..||.|.|.||.  ||...||:..:||.:| |.....|||..|  :........::|.:
  Rat   828 RLLVDDERGVAEPLLETD--TGDKVRGRHLVILSSVSDAAARHRLLAEQ--EVLAPQVVLAHGGS 888

  Fly   818 SVNRNMIPDF-FG-----IPESVELLSLEPYSKDQILIRLE---------NFNTEGNVVSFNIYP 867
            |...:..|.. |.     :|..|.||:|..:....:|:|||         |.|. .:.|:.|:..
  Rat   889 SPYHSQAPKMQFSALRRELPPQVHLLTLARWGPKMLLLRLEHQFAVKEDSNRNL-SSPVTLNLQN 952

  Fly   868 LFESLDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVT 932
            ||::.....:.||||..|..|..|.|.|:..| ||.|.     |.||       |.::.:.  :|
  Rat   953 LFKTFTINYLQETTLAANQPLSRVSRLKWMTD-TGPIS-----YPAP-------SRLDPTS--IT 1002

  Fly   933 LVPMQIRTFI 942
            |.|||||||:
  Rat  1003 LQPMQIRTFL 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	151/287 (53%)
		Alpha-mann_mid	323..398	CDD:286360	35/77 (45%)
		Glyco_hydro_38C	536..941	CDD:285047	157/427 (37%)
Man2b1	XP_006255335.1	GH38N_AMII_LAM_like	63..351	CDD:212121	151/287 (53%)
		Alpha-mann_mid	399..477	CDD:214875	35/77 (45%)
		Glyco_hydro_38C	617..1011	CDD:285047	156/419 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341787
Domainoid	1	1.000	409	1.000	Domainoid score	I670
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I460
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm44691
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770