DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and Man2b2

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001128443.2	Gene:	Man2b2 / 360955	RGDID:	1308840	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	1057	Identity:	286/1057 - (27%)
Similarity:	450/1057 - (42%)	Gaps:	198/1057 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            |...:|||||.||||:.||.:        ...|....:..||||||::...||||.||..||..|
  Rat    27 IRAFVVPHSHMDVGWVYTVQE--------SMRAYAANVYTTVVEELVRGRQRRFIAVEQEFFRLW 83

  Fly    67 Y----SEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGR 127
            :    |||.   ::.|::|:.:|||||..|...|:|||..|....:.|...|..:|.:|||.  |
  Rat    84 WDGVASEQQ---KQQVRQLLDEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--R 143

  Fly   128 PTVGWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLE-MEMIWQSSESL-KNSNIF 190
            |...|.:||||.|....::||...||....:|:|| |.|..|.:.: ::.:|..|.|| :...|:
  Rat   144 PQFSWHVDPFGASATTPTLFALAGFNAHLISRIDY-DLKDAMQEAQGLQFVWHGSPSLSEQQEIY 207

  Fly   191 TGM--LYNH-------YSAPPGFCFD-INCEDAPIIDGESYDN--------NVDARVSEFIDYVK 237
            |.:  ||::       :|...||.:: :.....|..|| .|.|        |:.......:..||
  Rat   208 THVMDLYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDG-VYPNMSEPVTVDNIHLYAEALVANVK 271

  Fly   238 NMSKSYRSTHIMVPMGDDFQYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQL 302
            ..:..:|:.|::.|.|.|.|:.:|:|.|.|||.|::|:|:| |....::|.|:|.:.|...||..
  Rat   272 QRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLEYINNR-SAQFGISVQYATLNDYFQALHDF 335

  Fly   303 KQTWPNKT-EDFFPYSSDSHSYWTGYFTSRPTQKRFHRD-------GNHFFQTVKQLSVLANLSG 359
            ..||..:. .||.||||:....|||:||||.|.|...|.       |...|...........|..
  Rat   336 NVTWDIRDHHDFLPYSSEPQQAWTGFFTSRSTLKGLARQASALLYAGESMFTRYMWPHPRGTLDP 400

  Fly   360 TQYSEDLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEF 424
            |...:.|..|..|:..:|||||:||||...|.:.|...|...:.|..                :.
  Rat   401 TWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYMEHLSMGMRGVH----------------KL 449

  Fly   425 ESCLELNISVCAFTQDTANNVIVTLVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVV---- 485
            .:.:.|:....:.|.........::.||||...|..:.:.....:..||||.||.|.:::.
  Rat   450 MASIALDRPPGSGTDTRPVGYSASVYNPLAWKITTIITLTVAFPSVSVTDELGRPVSAQIQNSTK 514

  Fly   486 -PVPWQVLALEHRPN-DTQHELVFEASVDKIANFLIRVLPSPK-NIAEDQVQFPVERSQDE---L 544
             |..:.:|.|...|. ..:|..|.....|:...   |.|.:|: |..:...:...:.||:.   :
  Rat   515 DPSAYDLLILTTIPGLSYRHYKVRRTRGDQAGT---RELVTPRANTLKFSRKLRNQTSQEGKLLV 576

  Fly   545 TVETSLVKLTFDTTTGGLKTV--KMNGFTENIQQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDI 607
            .|......|.||..|..|.::  :.:..|.::.|.|   ..||.|....:...|..|:|......
  Rat   577 PVMNDCYTLLFDQDTNMLHSIQDRQSNRTVHMTQEF---LEYRANGDVKQGPISDNYLFASNDTA 638

  Fly   608 EIVNNKVELSFYNGTKVKEVHQHVNEWISQVIRIYED----------------VNRVEFEWLVGP 656
            |.....|.:....||...:|.|:....|:....||..                ..|:|.::.|||
  Rat   639 EPSWEAVGMEMVVGTLATDVRQYFYRNITDQGYIYSIHTRLAHVHPSLAGELLCRRIEQQYQVGP 703

  Fly   657 IPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMSEAISGNYYPVTGQIS 721
            :    |:.:|.|.|.||:::|:...|:|:||.::      ||..:....|..|..||||:.....
  Rat   704 L----DLNREAILRTSSDLNSQQVLYSDNNGYQM------QRRPYKAFKSNPIPRNYYPMVQSAF 758

  Fly   722 LQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAFGVGE--ALNETQYGTGLIARGKIYL 784
            ::||:.|:.||.:|..|.:|.::|::|:||||||.|:..:.:..  .||:|.     :....::|
  Rat   759 IEDDKSRLVLLAERPHGVSSQENGQVEVMLHRRLWNNLVWDLNYNLTLNDTS-----VVHPVLWL 818

  Fly   785 ILD--------------AVDGKPNQRLLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFGIPESVE 835
            :|.              |:..:| ..||:...|:.          ..:::|...|....:|.|:.
  Rat   819 LLGPKSTTTALRPRSGVALQHRP-VVLLKELTDEE----------ETAIHRPHHPWPVTLPPSLH 872

  Fly   836 L--LSLE--PYSKD--QILIRLENFNTEGNVVS-----FNIYPLFES-LDGYQIWETTLDGNMLL 888
            |  |||.  .||::  |.|..|:..:.|...|:     ..::.|:|: .|.......|:|
  Rat   873 LQVLSLPGWQYSRNHAQHLKNLQRGHPEKPQVNLQRVLLRLHHLYEAGEDPVLSRPATVD----- 932

  Fly   889 EDVKRFKFAQDGTGSIPS-------------SVEYYH--------------APHNPLTANSTMNA 926
                 .|.|..|.||:.:             :::.:|              .|.:|
  Rat   933 -----LKIALRGLGSVVAVEERSLTGTWDVQTLQRWHWRTKIGQLKGHPTSPPRSP--------- 983

  Fly   927 SGFVVTLVPMQIRTFII 943
            .|.::|:.|.:||||.|
  Rat   984 GGSIITVYPKEIRTFFI 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	101/297 (34%)
		Alpha-mann_mid	323..398	CDD:286360	28/81 (35%)
		Glyco_hydro_38C	536..941	CDD:285047	110/480 (23%)
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	237/812 (29%)
Man2b2	NP_001128443.2	GH38N_AMII_Epman_like	27..352	CDD:212122	116/340 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020