DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and LManVI

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_609253.1	Gene:	LManVI / 34206	FlyBaseID:	FBgn0032069	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	979	Identity:	596/979 - (60%)
Similarity:	737/979 - (75%)	Gaps:	45/979 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAK 65
            |||:|:|||||||||||||||||:||.::.|||||||||:|||:.||:||.:||||||||.||||
  Fly    37 MINIHMVPHSHDDVGWLKTVDQYFYGHRSNIQHAGVQYIIDTVIAELIKDPARRFIQVETSFFAK 101

  Fly    66 WYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            |::||:||.::.|:|||.:|||||.||||||||||.|:||||:|||.|||::|.||||.|.||.:
  Fly   102 WWAEQSETAKQVVRKLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFTLGLKFLDDTFGSCARPRI 166

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKNSNIFTGMLY 195
            ||||||||||||.|||||||.::||||||||:.||..|:.:|.|||||.:|:||.|..||||:||
  Fly   167 GWQIDPFGHSREQASIFAQMGYDGEFFARMDHRDKNDRIDNLGMEMIWDASDSLSNDEIFTGLLY 231

  Fly   196 NHYSAPPGFCFDINCEDAPIIDGESYDNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQYED 260
            .|||||||:|||::|.|.||||.:||||||.:||.:|:.||.::::.|||.|||:||||||||||
  Fly   232 RHYSAPPGYCFDVHCGDDPIIDTKSYDNNVKSRVDDFLSYVTSVAQHYRSNHIMIPMGDDFQYED 296

  Fly   261 AAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSHSYWT 325
            |.||||||||||||||:||:.||..|:|||||:|||..||:..|||||||:|||||.||.:||||
  Fly   297 AQVNFKNMDKLIKYVNERQAEGSTFNLFYSTPACYLNSLHEGLQTWPNKTQDFFPYGSDDNSYWT 361

  Fly   326 GYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGTQYSEDLDNLSQAMGIMQHHDAVTGTEKQAV 390
            ||||||||||||.|||||..|..|||||.|.|:..|..|||:.|.:.||:||||||:||||||.|
  Fly   362 GYFTSRPTQKRFERDGNHILQVAKQLSVFAELNTKQQKEDLEYLREIMGVMQHHDAITGTEKQHV 426

  Fly   391 ASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVTLVNPLAH 455
            :.||||:|:.||:|..|:|||.||.||||.:|||||||:||||.||||:|.|:||:|||.|||||
  Fly   427 SDDYDRILYDAILGGVNTARDGLRKLTNLPNGEFESCLQLNISECAFTKDDADNVVVTLYNPLAH 491

  Fly   456 SSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIANFLIR 520
            :||||||||.|||||.|||||||.|.||||||.|||||||.|.|||||||||:||||||||:.|:
  Fly   492 TSTQYVRVPVKNENYEVTDEKGRVVASEVVPVAWQVLALEFRNNDTQHELVFKASVDKIANYYIK 556

  Fly   521 VLPS--PKNIA------------EDQVQFP---------------VERSQDELTVETSLVKLTFD 556
            .:.|  .||:|            |..::.|               .:..:.|..|:||.|||..|
  Fly   557 KVASQETKNVAAHTKSKRSIKAEEANLEVPKRFKKVHSLKNATETFDDDEGETVVQTSQVKLVID 621

  Fly   557 TTTGGLKTVKMNGFTENIQQTFGIYKGYRGNNGESKNRSSGAYVFRPY--GDIEIVNNKVELSFY 619
            ..||.||||:|||.:|||.|::|:|:.|          .|||||||.|  .|..:....||.:.|
  Fly   622 NKTGLLKTVEMNGVSENIDQSYGVYRTY----------DSGAYVFRQYHQADFIVQYEGVEFTVY 676

  Fly   620 NGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTD 684
            :|..||||||..:|:|||||||||..|.||.||.||||..:::.|:|::..|:|.|:|.|..|||
  Fly   677 DGALVKEVHQQFSEYISQVIRIYEGKNLVEIEWQVGPIEREEEFGREVVIIFNSTIASDGVSYTD 741

  Fly   685 SNGREILERERNQREHFTPDMS-EAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELE 748
            |||||:::|.::|||.|||.:. :..:.||||||.:|:|||.:|||.:||||||||.|:.:|:||
  Fly   742 SNGREMIKRVKDQRETFTPGLDRQPTAANYYPVTSRIALQDSKKRIAVLNDRAQGGASMLNGQLE 806

  Fly   749 LMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAVD-GKPNQRLLQHQLDQHFWKFFSK 812
            |||||||:.||.:||||||||.:||..:|||||:||||...| ....:|..:.::...|||||||
  Fly   807 LMLHRRLVRDDGYGVGEALNEEKYGQPMIARGKVYLILSPSDESTAAEREAEKEIHLPFWKFFSK 871

  Fly   813 SNGVASVNRNMIPDFFGIPESVELLSLEPYSKDQILIRLENF--NTEGNVVSFNIYPLFESLDGY 875
            :.|..:.....:|.|...|:||.||:|||::.|::|:|:|||  :|||.||||||.|:|:.|:|.
  Fly   872 NTGSTTAAAKSVPSFNDFPKSVHLLTLEPFNDDEVLLRVENFLDHTEGQVVSFNIRPIFDYLNGV 936

  Fly   876 QIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRT 940
            :|.|||||||:.|.|:|||||..|.:|..|.:|||:.:.|.||.|..:..||.|.|||.||||||
  Fly   937 EIRETTLDGNLPLSDMKRFKFHHDSSGQKPDAVEYFTSAHKPLAAEQSQEASEFSVTLHPMQIRT 1001

  Fly   941 FIIQ 944
            |||:
  Fly  1002 FIIK 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	195/273 (71%)
		Alpha-mann_mid	323..398	CDD:286360	52/74 (70%)
		Glyco_hydro_38C	536..941	CDD:285047	213/425 (50%)
LManVI	NP_609253.1	GH38N_AMII_LAM_like	38..312	CDD:212121	195/273 (71%)
		Alpha-mann_mid	359..434	CDD:286360	52/74 (70%)
		Glyco_hydro_38C	482..1002	CDD:285047	279/529 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450123
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	12	11.810