Protein Alignment LManI and Man2a2

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001425115.1
• Gene: Man2a2 / 308757
• RGDID: 1310238
• Length: 1175
• Species: Rattus norvegicus
• Alignment Length: 1094
• Identity: 293/1094 - (26%)
• Similarity: 463/1094 - (42%)
• Gaps: 243/1094 - (22%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.||:||.|:||...        .|:||:::|.:|.:|..|||:..|..|||||
  Rat   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :...:...:.||::||..|:||.|.|.|.|.|||..||.::|||...|.::|:...|  ..|..|
  Rat   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIW-QSSESLKNSNIFTGML- 194
            |.:||||||..|..:..:.........|:.|..||.......:|.:| |:.:|..:::||..|:
  Rat   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMP 350

  Fly   195 YNHYSAP------PGFC--FD--------INC--EDAPIIDGESYDNNVDARVSEFIDYVKNMSK 241
            :..|..|      |..|  ||        |||  :..|....|:   ||..|.:..:|..:..|:
  Rat   351 FYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEA---NVADRAALLLDQYRKKSR 412

  Fly   242 SYRSTHIMVPMGDDFQYE-----DAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQ 301
            .:||:.::||:||||:|:     ||  .|.|..:|..::|.:..  ..|...:.|.|.|...|:
  Rat   413 LFRSSVLLVPLGDDFRYDKPQEWDA--QFFNYQRLFDFLNSKPE--FHVQAQFGTLSEYFDALY- 472

  Fly   302 LKQT----------WPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLA- 355
             |:|          :|..:.|||.|:.....|||||:||||..|...|......:..:.|..||
  Rat   473 -KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLETHLRGAEVLYSLAL 536

  Fly   356 ------NLSGTQYSEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARD 411
                  .|:|.....|...|::|   :|:.|||||:|||.|:||..||...|.:::|..:....:
  Rat   537 AHARRSGLTGQYPLSDYAVLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIIN 601

  Fly   412 ALRSLTNLTSGEFES--------CLELN---ISVCAFTQDTANNV-----IVTLVNPLAHSSTQY 460
            |..   .|..|:.|:        .|:::   :|..|..:.|...:     .|.:.|||.......
  Rat   602 AAH---YLVLGDKETYSFDPRAPFLQMDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSV 663

  Fly   461 VRVPAKNENYIVTDEKGR------------------EVFSEVVPVPWQVL---ALEHRPNDTQHE 504
            |.:...:....|..|:|:                  :|:...|||....|   .|:.:| |....
  Rat   664 VSLLVNSPRVRVLSEEGQPLSVQISVQWSSATNMVPDVYQVSVPVRLPALGLGVLQLQP-DLDGP 727

  Fly   505 LVFEASVDKIANFLIRVLPSPKNIAEDQVQFP---VERSQDELTVETSLVKLTFDTTTGGLKTVK 566
            ...::||....|       ..|.....|..||   |:....:..:....:::.|...||.||:|:
  Rat   728 YTLQSSVHVYLN-------GVKLSVSRQTTFPLRVVDSGTSDFAISNRYMQVWFSGLTGLLKSVR 785

  Fly   567 M--NGFTENIQQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDIE--IVNNKVELSFYNGTKVKEV 627
            .  ....:.:.....:| |.|    .||:: ||||:|.|..:.:  :......|....|....||
  Rat   786 RVDEEQEQQVDMKLFVY-GTR----TSKDK-SGAYLFLPDNEAKPYVPKKPPVLRVTEGPFFSEV 844

  Fly   628 HQHVNEWISQVIRIY-----EDVN-RVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSN 686
            ..:. |...||||:|     |.:: .|.|:     :...|.|.||:..|..::|.|:|.|:||.|
  Rat   845 AAYY-EHFHQVIRLYNLPGVEGLSLDVSFQ-----VDIRDYVNKELALRIHTDIDSQGTFFTDLN 903

  Fly   687 GREILERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELML 751
            |.::..|:..::   .|     :..|:||:.....:||.::|:||...:|.|.:||.:|:||::|
  Rat   904 GFQVQPRKYLKK---LP-----LQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVIL 960

  Fly   752 HRRLLNDDAFGVGEALNETQ---------------------YGTGLIA--RGKIYLILDAVDGKP 793
            .|||:.||..|:|:.|.:.:                     :.:.|.|  ||.|:......:.|.
  Rat   961 DRRLMQDDNRGLGQGLKDNKITCNHFRLLLERRTLMSPEPGFFSKLAAMFRGLIFSSNTIRNSKV 1025

  Fly   794 NQR-------LLQHQLDQHF---------WKFFSKSNGVASVNRNMIPDFFGIPESVELLSLE-- 840
            .|.       ||.|....:.         .|..|.|..:.|.:....|    :|....||:|.
  Rat  1026 QQERSTSYPSLLSHMTSMYLNTPPLVLPVAKRESTSPTLHSFHPLASP----LPCDFHLLNLRML 1086

  Fly   841 ------PYSKDQILIRLENFN--TEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRFKFA 897
                  |.:...:::..:.|:  .|...:.||.              ||..|.:.|
  Rat  1087 PAEDTLPAADAALILHRKGFDCGLEAKNLGFNC--------------TTSQGKLAL--------- 1128

  Fly   898 QDGTGSI----------PSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRTF 941
                ||:          |:|:...:...:|  :|||      .::|.||:|.||
  Rat  1129 ----GSLFHGLDVLFLQPTSLTLLYPLASP--SNST------DISLEPMEISTF 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	102/298 (34%)
		PLN02701	4..765	CDD:178304	249/855 (29%)
Man2a2	NP_001425115.1	None