Protein Alignment LManI and Man2a1

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_037111.2
• Gene: Man2a1 / 25478
• RGDID: 3038
• Length: 1148
• Species: Rattus norvegicus
• Alignment Length: 1089
• Identity: 277/1089 - (25%)
• Similarity: 452/1089 - (41%)
• Gaps: 261/1089 - (23%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.|||||.:.|:   ::|     .|||.:.:|.:|.:||||:||..|..:.|||
  Rat   165 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKFIWSEISYLAKW 221

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.......:.|||.|:..|:||...|.|.|.||||.||.:::||...|.::|:...|  .:|..|
  Rat   222 WDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLG--VKPRSG 284

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESL-KNSNIFTGML- 194
            |.|||||||..|..:..:..|:.....|:.|..||...|...:|..|:.:..| ..::|...|:
  Rat   285 WAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLGSTTDILCHMMP 349

  Fly   195 YNHYSAP------PGFCFDINCEDAPIIDGESY------------DNNVDARVSEFIDYVKNMSK 241
            :..|..|      |..|...:.:..|   |..|            ..||.:|....:|..:..||
  Rat   350 FYSYDIPHTCGPDPKICCQFDFKRLP---GGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSK 411

  Fly   242 SYRSTHIMVPMGDDF---QYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQL- 302
            .:|:..::.|:||||   :|.:..:.::|.::|..|:|.:...  :|.:.:.|.|.|...|.:.
  Rat   412 LFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQPHL--KVKIQFGTLSDYFDALEKSV 474

  Fly   303 -------KQTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGT 360
                   :..:|..:.|||.|:.....||:|||||||..||..|......:|.:.|..||.....
  Rat   475 AAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRLRTAEILYHLALKQAQ 539

  Fly   361 QY-------SEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDA--- 412
            :|       |.....|::|   :|:.|||||:|||.|..|..||...||:::...|....|:
  Rat   540 KYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFL 604

  Fly   413 --LRSLTNLTSGEFESCLELNISVCAFTQDTANNVI---------VTLVNPLAHSSTQYVRVPAK 466
              |:......|...::.||::....:.......|:|         :.:.||........|.|...
  Rat   605 LILKDKKLYQSDPSKAFLEMDTKQSSQDSLPKKNIIQLSAQEPRYLVVYNPFEQERHSVVSVRVN 669

  Fly   467 NENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIANFLIRVLPSP------ 525
            :....|..:.|:.|..:|..| |:.:   ...:...:|:.|.|.:..:...:.::|.|.
  Rat   670 SATVKVLSDLGKAVEVQVSAV-WKDM---RTTSQAAYEVAFLAHLPPLGLKVYKILESQSSSSHL 730

  Fly   526 -------------------KNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTVKMNGFT 571
                               ||:.:         |.|.:|:|.|.:.|.||.:  ||.. |:....
  Rat   731 ADYFLYNNDGQAESGIFHMKNMVD---------SGDAITIENSFLTLGFDRS--GLME-KVRRKE 783

  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------------------YGDI----EIV 610
            :|.||...:...:.|..  :|...||||:|.|                      |.|:    |.|
  Rat   784 DNKQQELKVQFLWYGTT--NKRDKSGAYLFLPDGQGQPYVSLRTPFVRVTRGRIYSDVTCFLEHV 846

  Fly   611 NNKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNI 675
            .:||.|....|.:.:.:.      :|.::.|....||                  ||:.|.||.|
  Rat   847 THKVRLYHIQGIEGQSME------VSNIVDIRSVHNR------------------EIVMRISSKI 887

  Fly   676 SSKGKFYTDSNGREILERERNQREHFTPDMSE-AISGNYYPVTGQISLQDDEKRITLLNDRAQGG 739
            :::.::|||.||.:|..|.         .|:: .:..|.||::....:||...|:|||:.::.|.
  Rat   888 NNQNRYYTDLNGYQIQPRR---------TMAKLPLQANVYPMSTMAYIQDAAHRLTLLSAQSLGA 943

  Fly   740 TSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAVDGKPNQR-------- 796
            :|:..|::|:.:.|||:.||..|:|:.:::.:....|..     ::|:..:|...:.
  Rat   944 SSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFR-----ILLEKRNGMNMEEDKKSPVSY 1003

  Fly   797 --LLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFG--IPE-SVELLSLEPYSKDQIL-------I 849
              ||.|...             |.:|...:|....  :|. ::|||     |:.::|       |
  Rat  1004 PSLLSHMTS-------------AFLNHPFLPMVLSGQLPSPAIELL-----SEFRLLQSSLPCDI 1050

  Fly   850 RLENFNTEGNVVSFNIYPLFESLDGY----------QIWE------------TTLDGNMLLEDVK 892
            .|.|..|..:.|.          .||          ::::            :|..|.|.:.  |
  Rat  1051 HLVNLRTIQSKVG----------KGYSDEAALILHRKVFDCQLSSRAMGLPCSTTQGKMSIP--K 1103

  Fly   893 RF-KFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRT 940
            .| .||.:  ..||||:...|:|  |...|::      .|:|.||:|.|
  Rat  1104 LFNNFAVE--SFIPSSLSLMHSP--PDAQNTS------EVSLSPMEIST 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	95/296 (32%)
		PLN02701	4..765	CDD:178304	233/867 (27%)
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	277/1089 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1148		10/30 (33%)