DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and MAN2B2

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_056089.1	Gene:	MAN2B2 / 23324	HGNCID:	29623	Length:	1009	Species:	Homo sapiens

Alignment Length:	1062	Identity:	275/1062 - (25%)
Similarity:	450/1062 - (42%)	Gaps:	196/1062 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            |...:|||||.||||:.||.:        ...|....:..:|||||.:...||||.||..||..|
Human    27 IRAFVVPHSHMDVGWVYTVQE--------SMRAYAANVYTSVVEELARGQQRRFIAVEQEFFRLW 83

  Fly    67 YSEQTETVQR-AVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            :.......|: .|::|:.:|||||..|...|:|||..|....:.|...|..:|.:|||.  ||..
Human    84 WDGVASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--RPQF 146

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLE-MEMIWQSSESL-KNSNIFTGM 193
            .|.:||||.|....::||...||....:|:|| |.|..|.:.. ::.:|:.|.|| :...|||.:
Human   147 SWHVDPFGASATTPTLFALAGFNAHLGSRIDY-DLKAAMQEARGLQFVWRGSPSLSERQEIFTHI 210

  Fly   194 L--YNH-------YSAPPGFCFD-INCEDAPIIDGESYDN--------NVDARVSEFIDYVKNMS 240
            :  |::       :|...||.:: :.....|..|| .|.|        |::......:..||..:
Human   211 MDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPQDG-VYPNMSEPVTPANINLYAEALVANVKQRA 274

  Fly   241 KSYRSTHIMVPMGDDFQYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQT 305
            ..:|:.|::.|.|.|.|:.:|:|.|.|||.|:.::|. .:....|:|.|:|...|...||.|..|
Human   275 AWFRTPHVLWPWGCDKQFFNASVQFANMDPLLDHINS-HAAELGVSVQYATLGDYFRALHALNVT 338

  Fly   306 WPNKT-EDFFPYSSDSHSYWTGYFTSRPTQKRFHR-------DGNHFFQTVKQLSVLANLSGTQY 362
            |..:. .||.|||::....|||::|||.:.|...|       .|...|......:...:|..|..
Human   339 WRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALLYAGESMFTRYLWPAPRGHLDPTWA 403

  Fly   363 SEDLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESC 427
            .:.|..|..|:..:|||||:||||...|...|...|...::|..       :.:.::...|
Human   404 LQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHLASGMLGMR-------KLMASIVLDE---- 457

  Fly   428 LELNISVCAFTQDTANNVIVTLVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVL 492
            |:....:.|.:.........::.||||.:.|..|.:........||||.|.       |||.|:.
Human   458 LQPQAPMAASSDAGPAGHFASVYNPLAWTVTTIVTLTVGFPGVRVTDEAGH-------PVPSQIQ 515

  Fly   493 ALEHRPNDTQHELVFEASVDKIA--NFLIRVLPSPKNIAEDQVQFPVERSQDELTVETSLVKLT- 554
            .....|  :.::|:...::..::  ::.||    |...|::..|.|.......|.....|.:.|
Human   516 NSTETP--SAYDLLILTTIPGLSYRHYNIR----PTAGAQEGTQEPAATVASTLQFGRRLRRRTS 574

  Fly   555 -----------------FDTTTGGLKTV--KMNGFTENIQQTFGIYKGYRGNNGESKNRSSGAYV 600
                             .|..|..:.::  :.:..|..:.|.|   ..|..|....:...|..|:
Human   575 HAGRYLVPVANDCYIVLLDQDTNLMHSIWERQSNRTVRVTQEF---LEYHVNGDVKQGPISDNYL 636

  Fly   601 FRPYGDIEIVNNKVELSFYNGTKVKEVHQH-------------VNEWISQVIRIYED---VNRVE 649
            |.|..........||:....|..|.|:.|:             :...::.|.:.::.   .:|:|
Human   637 FTPGKAAVPAWEAVEMEIVAGQLVTEIRQYFYRNMTAQNYTYAIRSRLTHVPQGHDGELLCHRIE 701

  Fly   650 FEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMSEAISGNYY 714
            .|:..||:    ::.:|.:.|.|:|::|:...|:|:||.::      ||..:...::.:|:.|||
Human   702 QEYQAGPL----ELNREAVLRTSTNLNSQQVIYSDNNGYQM------QRRPYVSYVNNSIARNYY 756

  Fly   715 PVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLN--DDAFGVGEALNETQYGTGLI 777
            |:.....::|.:.|:.||::||.|.:|..:|::|:||||||.|  |...|....||:|.     :
Human   757 PMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNLTLNDTS-----V 816

  Fly   778 ARGKIYLILD--AVDGKPNQR---LLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFGIPESVELL 837
            ....::|:|.  ::.....||   .|||:.    ...|....|.|       |...| |:..|.:
Human   817 VHPVLWLLLGSWSLTTALRQRSALALQHRP----VVLFGDLAGTA-------PKLPG-PQQQEAV 869

  Fly   838 SLEP-------------YSKD---------------------QILIRLENFNTEG------NVVS 862
            :|.|             ||.:                     ::|:||.:....|      ..|:
Human   870 TLPPNLHLQILSIPGWRYSSNHTEHSQNLRKGHRGEAQADLRRVLLRLYHLYEVGEDPVLSQPVT 934

  Fly   863 FNIYPLFESLDG-YQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNA 926
            .|:..:.::|.. ..:.|.:|.|...|..:.|:.: :.|.|.           |...|.:.:...
Human   935 VNLEAVLQALGSVVAVEERSLTGTWDLSMLHRWSW-RTGPGR-----------HRGDTTSPSRPP 987

  Fly   927 SGFVVTLVPMQIRTFII--QQK 946
            .|.::|:.|.:||||.|  ||:
Human   988 GGPIITVHPKEIRTFFIHFQQQ 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	97/294 (33%)
		Alpha-mann_mid	323..398	CDD:286360	26/81 (32%)
		Glyco_hydro_38C	536..941	CDD:285047	104/488 (21%)
MAN2B2	NP_056089.1	GH38N_AMII_Epman_like	27..352	CDD:212122	112/337 (33%)
		Alpha-mann_mid	358..439	CDD:214875	26/80 (33%)
		Glyco_hydro_38C	581..1002	CDD:285047	100/462 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	972..991		5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920