DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and aman-3

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001361919.1	Gene:	aman-3 / 172178	WormBaseID:	WBGene00018594	Length:	1046	Species:	Caenorhabditis elegans

Alignment Length:	1006	Identity:	246/1006 - (24%)
Similarity:	422/1006 - (41%)	Gaps:	201/1006 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|:::|.:|.|.|||:|.::|...:..         |||.:.:.::|:...||:..|..||.:|
Worm   119 LKVYVLPFTHVDPGWLETFERYTKSTNQ---------ILDNMHQFMMKNEKMRFMWAEFVFFERW 174

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :|.|.|.|:..|||||.:||||.|.|:|.|.|||..::...||....|.:::...||.  :|...
Worm   175 WSLQNEQVKEDVKKLVTEGRLELATGSWVMTDEANPYFPVSVDNIVEGFQFIHKNFGI--KPQTM 237

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIW-QSSESLKNSNIFTGML- 194
            |..||||:|..:..:|.:...:.....|:.:..|:.......:...| |..::....::.|.:|
Worm   238 WSNDPFGYSNSVPYLFKKSGVHRTVINRIHHKLKQTLQSQKAIPFKWRQYFDATGEDDVLTQILP 302

  Fly   195 YNHYSA--PPGFCFDINCE---------DAPIIDGESYDN-NVDARVSEFIDYVKNMSKSYRSTH 247
            |.||..  ..|....:.||         ..|....|...| ||.|:..:.::.::.||:.|::..
Worm   303 YTHYDILNSCGSDASVCCEFDFKRMTHWSCPGPKPEKITNANVAAKAEKLVNQLEKMSEMYKAPV 367

  Fly   248 IMVPMGDDFQYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTW------ 306
            |::..||||:::......:..|..|. |.|..:.||:|.:.:.|.:.|..:|    :.|
Worm   368 ILMMHGDDFRFDMIEEWNQQHDNFIP-VFDEINKGSRVEIRFGTFTDYFNDL----EKWYSNNKD 427

  Fly   307 ---PNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVK----QLSVL-ANLSGTQYS 363
               |..:.|||||......|||||:|:||.   |.|.|......::    .||:| .||...:..
Worm   428 SEPPTVSGDFFPYMCALGDYWTGYYTTRPF---FKRQGRLLHSLIRNGDIMLSMLRVNLKQRKIG 489

  Fly   364 EDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFE 425
            |::..|..|   :.:.|||||:|||.|.:|..:|..||..:||...       ..|.|||..:.:
Worm   490 ENVKRLEAARRNLALFQHHDAITGTSKVSVMDNYSELLHASIVSTN-------IVLENLTKSDID 547

  Fly   426 SCLELNISVCAFTQDTANNVIVTLVNPLAHSSTQYVRVPAKNENYIVTD-----EKGREVFSEVV 485
            ....::..:          .:.|:|:  ..||.:.:|: ..:..:.:||     .|.|||   :|
Worm   548 LYPRIHDGI----------ELQTIVD--LESSEKEIRI-FNSHLFEITDVFKIRVKEREV---IV 596

  Fly   486 PVPWQVLALEHRP-------NDTQHELVFEASVDKIANFLIRV--------LPSPKNIAEDQ--- 532
            .:..:::..:..|       ......|:|:|:|..::...::|        ....|..|:|.
Worm   597 SIDGKIIEAQLEPFFQKSKVEKDSFLLLFQATVLPLSMMKVKVQRGDSGGLTKMAKIEAKDTNAW 661

  Fly   533 ---VQFPVERSQDELTVETSLVKLTFDTTTGGLKTVKMNGFTEN----IQQTFGIYKGYRGNNGE 590
               ..:.:..|.....:||...|::.|..||.:::|  |..::|    .||:|..||...|
Worm   662 DLGSSWTIASSTSAPNLETPYFKVSNDPITGAIQSV--NKLSDNSKFHCQQSFYNYKEAGG---- 720

  Fly   591 SKNRSSGAYVFRPYGDIEIVNNKVELSFYNGTKVK-EVHQHVNEWISQVIRIYEDVNRVEFEWLV 654
                  |||:.|      :..|..|:..|...||. .:.|.:.:..:.|::      |:....:.
Worm   721 ------GAYLMR------LHTNPKEIIEYQWLKVSGPLRQSIYQKSTNVLQ------RLSIHNVE 767

  Fly   655 GPIPTDDDV----------GKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMSEAI 709
            ||...:.|:          ..|::||||:. ..|...||||.|.::|.|:..:.         .:
Worm   768 GPSGEEVDISMSIDITKERNTELMTRFSTK-WDKPLTYTDSVGMQLLRRDFYKL---------PV 822

  Fly   710 SGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAFGVGEALNETQYGT 774
            ..||||:.....||..::|::::::...|...|:.|.:|:.:.|.|..||..|:         ||
Worm   823 QSNYYPMPTAAVLQSGKQRLSIVSNVEHGARFLESGTVEINIDRILNQDDGKGL---------GT 878

  Fly   775 GLIA--------RGKIYLILDAVDGKP--NQRLLQHQLDQHFWKFFSKSNGVASV-------NR- 821
            |..|        ..|..||.|:::..|  |.|...|.        |.....|.::       ||
Worm   879 GPDAIPIDMKPVDMKFKLIFDSLESDPTENSRYSTHS--------FRAQQAVQTIIYPPMMFNRP 935

  Fly   822 -------NMIPDFFGI--PESVELLSLEPYSKDQILIRLENFNTE---------GNVVSFNIYPL 868
                   ..|.:...:  |..::||::.|...::.|:.|....|.         |..:..::..|
Worm   936 PKKEEDIEEIEEISNLKFPCDIQLLTVRPLEDNKQLLILYRHATVCSSQKVGNCGGELKSSLMDL 1000

  Fly   869 FESLDGYQIWETTLDGNMLLEDVKRFKFAQD 899
            ...|...|:.:|.|.|...:..:.:.::..|
Worm  1001 LIKLGAKQVQKTDLSGVTRVGGIIKVEYLPD 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	80/287 (28%)
		Alpha-mann_mid	323..398	CDD:286360	30/82 (37%)
		Glyco_hydro_38C	536..941	CDD:285047	92/415 (22%)
aman-3	NP_001361919.1	PLN02701	117..978	CDD:178304	237/951 (25%)
aman-3	NP_001361919.1	GH38N_AMII_GMII_SfManIII_like	118..452	CDD:212120	99/348 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810