Protein Alignment LManI and Man2b2

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_032576.2
• Gene: Man2b2 / 17160
• MGIID: 1195262
• Length: 1018
• Species: Mus musculus
• Alignment Length: 1057
• Identity: 287/1057 - (27%)
• Similarity: 449/1057 - (42%)
• Gaps: 182/1057 - (17%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            |...:|||||.||||:.||.:        ...|....:..|||.||::...||||.||..||..|
Mouse    27 IRAFVVPHSHMDVGWVFTVQE--------SMRAYAANVYTTVVAELVRGGQRRFIAVEQEFFRLW 83

  Fly    67 Y----SEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGR 127
            :    |||.   ::.|::|:.:|||||..|...|:|||..|....:.|...|..:|.:|||.  |
Mouse    84 WDGVASEQQ---KQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--R 143

  Fly   128 PTVGWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEM-EMIWQSSESLK-NSNIF 190
            |...|.:||||.|....::||...||....:|:|| |.|..|.:.:| :.:|..|.||. ...||
Mouse   144 PQFSWHVDPFGASATTPTLFALAGFNAHLISRIDY-DLKDAMQEAQMLQFVWHGSPSLSGQQEIF 207

  Fly   191 TGMLYNHYS--AP--------PGFCFD-INCEDAPIIDGESYDN--------NVDARVSEFIDYV 236
            |.:: :|||  .|        .||.:: :.....|..|| .|.|        |:.......:..|
Mouse   208 THVM-DHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDG-VYPNMSEPVTGANIHLYAEALVANV 270

  Fly   237 KNMSKSYRSTHIMVPMGDDFQYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQ 301
            |..:..:|:.|::.|.|.|.|:.:|:|.|.|||.|:.|:|.|.:... ::|.|:|.:.|...||.
Mouse   271 KQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRTAQFG-ISVQYATLNDYFQALHA 334

  Fly   302 LKQTWPNKT-EDFFPYSSDSHSYWTGYFTSRPTQKRFHRD-------GNHFFQTVKQLSVLANLS 358
            ...||..:. :||.||||:....|||::|||.|.|...|.       |...|...........|.
Mouse   335 TNMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFTRYMWPDPSGTLD 399

  Fly   359 GTQYSEDLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAEN-SARDALRSLTNLTSG 422
            .|...:.|..|..|:..:|||||:||||...|.:.|...|...::|... ....||.......:|
Mouse   400 PTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGMLGVRKLMVSIALGGPPGSGTG 464

  Fly   423 EFESCLELNISVCAFTQDTANNVIVTLVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVV-- 485
            ..:..:...::..............::.||||...|..:.:.....|..||||.|..|.:::.
Mouse   465 APKDIMGPQVTPVLSVDTRPVGYSASVYNPLAWKITTIITLTVAFPNVSVTDELGHPVSTQIQNS 529

  Fly   486 ---PVPWQVLALEHRPN-DTQHELVFEASVDKIANFLIRVLPSPK-NIAEDQVQFPVERSQDE-- 543
               |..:.:|.|...|. :.:|..|..|..|:...   |.|.:|: |..:..::...:.||:.
Mouse   530 TKDPSAYDLLILTTIPGLNYRHYQVMHARGDQAGT---RELVAPRANTLKFSLKLRNQPSQEGKR 591

  Fly   544 -LTVETSLVKLTFDTTTGGLKTVKMNGFTENIQQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDI 607
             :.|......|.||..|..|.:::.......::.|....: |:.|....:...|..|:|.|....
Mouse   592 LVPVMNDCYILLFDQDTNMLHSIQDRQSNRTVRMTQEFLE-YQANWDVKQGPISDNYLFAPNNTA 655

  Fly   608 EIVNNKVELSFYNGTKVKEVHQHVNEWISQVIRIYED--------------VNRVEFEWLVGPIP 658
            |.....|.:....||.|.::.|:...:|:....||..              ..|:|.::.|||:
Mouse   656 EPSWEAVGMEMVAGTLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPL- 719

  Fly   659 TDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMSEAISGNYYPVTGQISLQ 723
               |:.:|.|.|.||:::|:...|:|:||.::      ||..:....|..|..||||:.....::
Mouse   720 ---DLNREAILRTSSDLNSQQVLYSDNNGYQM------QRRPYKAFKSNPIPRNYYPMVQSAFIE 775

  Fly   724 DDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAFGV--GEALNET---------------- 770
            ||:.|:.||.:|..|.:|..:|::|:||||||.|:.|:.:  ...||:|
Mouse   776 DDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLWNNLAWDLKYNLTLNDTSIVHPVLWLMLGPKST 840

  Fly   771 ------QYGTGLIARGKIYLILDAVDGK---------------PNQRLLQHQLDQHFWKFFSKSN 814
                  :.|..| ..|.:.|:.:..|.:               ||..|  ..|....|. :|:|:
Mouse   841 MTALHPRSGVAL-QHGPVVLLKELADEETPVHGPHNPWPVTLPPNLHL--QILSVPGWT-YSRSH 901

  Fly   815 GVASVNRNMIPDFFGIPES---------VELLSLEPYSKDQILIRLENFNTE------GNVVSFN 864
              |...||:..   |.||.         :.|..|....:|.:|.|....:.:      |:||:
Mouse   902 --AQHLRNLQR---GHPEKPQANLQRVLLRLRHLYEAGEDPVLSRPATVDLKVVLRGLGSVVA-- 959

  Fly   865 IYPLFESLDGYQIWETTLDGNMLLEDVKRFKFA--QDGTGSIPSSVEYYHAPHNPLTANSTMNAS 927
                        :.|.:|.|...::.::|:.::  .|.....|:|      |..|        ..
Mouse   960 ------------VEERSLTGTWDVQMLQRWHWSTKTDHLKGHPTS------PPRP--------PG 998

  Fly   928 GFVVTLVPMQIRTFIIQ 944
            |.::|:.|.:||||.|:
Mouse   999 GSIITVYPKEIRTFFIK 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	103/298 (35%)
		PLN02701	4..765	CDD:178304	240/820 (29%)
Man2b2	NP_032576.2	PLN02701	27..807	CDD:178304	237/810 (29%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	117/341 (34%)