Protein Alignment LManI and Man2b1

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001411770.1
• Gene: Man2b1 / 17159
• MGIID: 107286
• Length: 1024
• Species: Mus musculus
• Alignment Length: 996
• Identity: 413/996 - (41%)
• Similarity: 579/996 - (58%)
• Gaps: 79/996 - (7%)

  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQ-----------NKIQHAGVQYILDTVVEELLKDSSRR 54
            |:||||:||:||||||||||||||||..           :.:|||.||||||:||..||:..:||
Mouse    62 MLNVHLLPHTHDDVGWLKTVDQYYYGMDLDFLNFMPTVLSDVQHASVQYILDSVVSSLLEKPTRR 126

  Fly    55 FIQVETFFFAKWYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLK 119
            ||.||..||::|:.:||...|.||:.||.||||||..|.|.|||||..||.::|||..||||:|:
Mouse   127 FIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQ 191

  Fly   120 DTFGDCGRPTVGWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESL 184
            ||||..|.|.|.|.|||||||||.||:||||.|:|.|..|:||.||..|...|.||.:|::|:||
Mouse   192 DTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRKKKLRMEELWRASDSL 256

  Fly   185 K--NSNIFTGMLYNHYSAPPGFCFDINCEDAPIIDG-ESYDNNVDARVSEFIDYVKNMSKSYRST 246
            :  .:::|||:|.|:|:.|...|:|:.|.|.|::|. .|.:.|....|:.|:....:....||:.
Mouse   257 EPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTN 321

  Fly   247 HIMVPMGDDFQYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTE 311
            |.::.||.||.||:|.:.||||||||:.||.:|..||.|:|.||||:|||:||::...||..|.:
Mouse   322 HTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLTWTVKED 386

  Fly   312 DFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVL----ANLSGTQYSEDLDNLSQA 372
            |||||:...|.:|||||:|||..||:.|...:|.|...||..|    ||: |...|.|...|.:|
Mouse   387 DFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEANV-GPYGSGDSAPLQEA 450

  Fly   373 MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAF 437
            |.::||||||:||.:|.|.:||.|.|.......|....:||..|::... .|..|.|||||:|..
Mouse   451 MAVLQHHDAVSGTARQNVVNDYARQLAAGWGPCEVLVSNALARLSHYKQ-NFSFCRELNISICPV 514

  Fly   438 TQDTANNVIVTLVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQ 502
            :| |:....|||.|||.....|.||:|....|:||.|...:.:.|.||.||      .:.....|
Mouse   515 SQ-TSERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVP------SYYSETYQ 572

  Fly   503 HELVFEASVDKI--ANFLIRVLPSPKNIAEDQVQFP-VERSQDELTVETSLVKLTFDTTTGGLKT 564
            .||:|.|||..:  :.:.:..:....:.|.:.:..| ..:|...|.:|...::.|||:.||.|..
Mouse   573 WELLFPASVPALGFSTYSVAKMSDLNHQAHNLLSRPRKHKSHHVLVIENKYMRATFDSGTGLLMK 637

  Fly   565 VKMNGFTENIQQTFGI-----YKGYRGNNG-ESKNRSSGAYVFRP-YGDIEIVNNKVELSFYNGT 622
            :      ||::|...:     :..|..:.| |..:::||||:||| .|....|:...::|.....
Mouse   638 I------ENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTA 696

  Fly   623 KVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNG 687
            .|:||||:.:.|.|||||:|:....:|.||.|||||..||.|||:|:||.:.:.:||:|:|||||
Mouse   697 LVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNG 761

  Fly   688 REILERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLH 752
            ||||:|..:.|..:|.:.:|.::||||||..:|.:.|.:.::|:|.||:|||:||:||.||||:|
Mouse   762 REILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYITDGQMQLTVLTDRSQGGSSLQDGSLELMVH 826

  Fly   753 RRLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAV-DGKPNQRLLQHQLDQHFWKFFSKSNGV 816
            ||||.||..||.|.|.||.  ||...||:..::|.:| |.....|||..| :....:......|.
Mouse   827 RRLLVDDDRGVSEPLLETD--TGDKVRGRHLVLLSSVSDAAARHRLLAEQ-EVLAPQVVLSLGGS 888

  Fly   817 ASVNRNMIP--DFFG----IPESVELLSLEPYSKDQILIRLEN-----FNTEGNV---VSFNIYP 867
            :..:....|  .|.|    :|..|.||:|..:....:|:|||:     .:::.|:   |:.|:..
Mouse   889 SPYHSRATPKTQFSGLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQN 953

  Fly   868 LFESLDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVT 932
            ||::.....:.||||..|..|....|.|:.   |.:.|:|   |..|       |.::.:.  ||
Mouse   954 LFQTFTINYLQETTLAANQPLSRASRLKWM---TNTGPTS---YPEP-------SKLDPTS--VT 1003

  Fly   933 LVPMQIRTFIIQ---QKYIPS 950
            |.||:||||:..   |::.|:
Mouse  1004 LKPMEIRTFLASVQWQEHRPA 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	148/287 (52%)
		PLN02701	4..765	CDD:178304	353/788 (45%)
Man2b1	NP_001411770.1	None