Protein Alignment LManI and Man2a1

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_032575.2
• Gene: Man2a1 / 17158
• MGIID: 104669
• Length: 1150
• Species: Mus musculus
• Alignment Length: 1079
• Identity: 280/1079 - (25%)
• Similarity: 466/1079 - (43%)
• Gaps: 227/1079 - (21%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.|||||.:.|:   ::|     .|||.:.:|.:|.:||||:|:..|..:.|||
Mouse   165 LQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKFMWSEISYLAKW 221

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.......:.|||.|:..|:||...|.|.|.||||.||.:::||...|.::|:...|  .:|..|
Mouse   222 WDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLG--VKPRSG 284

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKN-SNIFTGML- 194
            |.|||||||..||.:..:..|:.....|:.|..||...|...:|..|:.:..|.: ::|...|:
Mouse   285 WAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMP 349

  Fly   195 YNHYSAP------PGFCFDINCEDAPIIDGESY------------DNNVDARVSEFIDYVKNMSK 241
            :..|..|      |..|...:.:..|   |..|            ..||.:|....:|..:..||
Mouse   350 FYSYDIPHTCGPDPKICCQFDFKRLP---GGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSK 411

  Fly   242 SYRSTHIMVPMGDDF---QYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQL- 302
            .:|:..::.|:||||   :|.:..:..:|.::|..|:|.:...  :|.:.:.|.|.|...|.:.
Mouse   412 LFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQPHL--KVKIQFGTLSDYFDALEKAV 474

  Fly   303 -------KQTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGT 360
                   :..:|..:.|||.|:.....||:|||||||..||..|......:..:.|..||.....
Mouse   475 AAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQAQ 539

  Fly   361 QY-------SEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDA--- 412
            :|       |.....|::|   :|:.|||||:|||.|..|..||...||:::...|....|:
Mouse   540 KYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFL 604

  Fly   413 --LRSLTNLTSGEFESCLELNISVCAFTQDTANNVIV-----------TLVNPLAHSSTQYVRVP 464
              |:......|...::.||::..  ..:||:....|:           .:.||........|.:.
Mouse   605 LILKDKKLYQSDPSKAFLEMDTK--QSSQDSLPQKIIIQLSAQEPRYLVVYNPFEQERHSVVSIR 667

  Fly   465 AKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQ------HELVFEASVDKIANFLIRVLP 523
            ..:....|..:.|:       ||..||.|:.   ||.:      :|:.|.|.:..:...:.::|.
Mouse   668 VNSATVKVLSDSGK-------PVEVQVSAVW---NDMRTISQAAYEVSFLAHIPPLGLKVFKILE 722

  Fly   524 SPKN--------------IAEDQVQFPVER---SQDELTVETSLVKLTFDTTTGGLKTVKMNGFT 571
            |..:              :||:.: |.|:.   :.|.:|:|...:.:.||.:  ||.. |:....
Mouse   723 SQSSSSHLADYVLYNNDGLAENGI-FHVKNMVDAGDAITIENPFLAIWFDRS--GLME-KVRRKE 783

  Fly   572 ENIQQTFGIYKGYRGNNGESKNRSSGAYVFRP----------------------YGDI----EIV 610
            ::.|....:...:.|..  :|...||||:|.|                      |.|:    |.|
Mouse   784 DSRQHELKVQFLWYGTT--NKRDKSGAYLFLPDGQGQPYVSLRPPFVRVTRGRIYSDVTCFLEHV 846

  Fly   611 NNKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDVGKEIITRFSSNI 675
            .:||.|....|.:.:.:.      :|.::.|....||                  ||:.|.||.|
Mouse   847 THKVRLYNIQGIEGQSME------VSNIVNIRNVHNR------------------EIVMRISSKI 887

  Fly   676 SSKGKFYTDSNGREILERERNQREHFTPDMSE-AISGNYYPVTGQISLQDDEKRITLLNDRAQGG 739
            :::.::|||.||.:|..|.         .||: .:..|.||:.....:||.|.|:|||:.::.|.
Mouse   888 NNQNRYYTDLNGYQIQPRR---------TMSKLPLQANVYPMCTMAYIQDAEHRLTLLSAQSLGA 943

  Fly   740 TSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILD---AVDGKPNQR----- 796
            :|:..|::|:.:.|||:.||..|:|:.:::.:....|..     ::|:   ||:.:..::
Mouse   944 SSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFR-----ILLEKRSAVNMEEEKKSPVSY 1003

  Fly   797 --LLQHQLD---QHFWKFFSKSNGVASVNRNMIPDF----FGIPESVELLSL--------EPYSK 844
              ||.|...   .|.:.....|..:.|....::.:|    ..:|..:.|::|        :.||.
Mouse  1004 PSLLSHMTSSFLNHPFLPMVLSGQLPSPAFELLSEFPLLQSSLPCDIHLVNLRTIQSKMGKGYSD 1068

  Fly   845 DQILIRLENFNTEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRF-KFAQDGTGSIPSSV 908
            :..||    .:.:|....|       |..|..:..:|..|.|.:  :|.| |||.:..  :|||:
Mouse  1069 EAALI----LHRKGFDCQF-------SSRGIGLPCSTTQGKMSV--LKLFNKFAVESL--VPSSL 1118

  Fly   909 EYYHAPHNPLTANSTMNASGFVVTLVPMQIRTFIIQQKY 947
            ...|:|.:      ..|.|  .|:|.||:|.||.|:.::
Mouse  1119 SLMHSPPD------AQNMS--EVSLSPMEISTFRIRLRW 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	95/296 (32%)
		PLN02701	4..765	CDD:178304	234/867 (27%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	280/1076 (26%)