DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and Man2a2

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_766491.2	Gene:	Man2a2 / 140481	MGIID:	2150656	Length:	1152	Species:	Mus musculus

Alignment Length:	1066	Identity:	294/1066 - (27%)
Similarity:	464/1066 - (43%)	Gaps:	210/1066 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.||:||.|:||...        .|:||:::|.:|.:|..|||:..|..|||||
Mouse   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :...:...:.||::||..|:||.|.|.|.|.|||..||.::|||...|.::|:...|  ..|..|
Mouse   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIW-QSSESLKNSNIFTGML- 194
            |.:||||||..|..:..:.........|:.|..||.......:|.:| |..:|..:::||..|:
Mouse   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMP 350

  Fly   195 YNHYSAP------PGFC--FD--------INC--EDAPIIDGESYDNNVDARVSEFIDYVKNMSK 241
            :..|..|      |..|  ||        |||  :..|....|:   ||..|.:..:|..:..|:
Mouse   351 FYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEA---NVADRAALLLDQYRKKSR 412

  Fly   242 SYRSTHIMVPMGDDFQYE-----DAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQ 301
            .:||..::||:||||:|:     ||  .|.|..:|..::|.:..  ..|...:.|.|.|...|:
Mouse   413 LFRSNVLLVPLGDDFRYDKPQEWDA--QFFNYQRLFDFLNSKPE--FHVQAQFGTLSEYFDALY- 472

  Fly   302 LKQT----------WPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLA- 355
             |:|          :|..:.|||.|:.....|||||:||||..|...|......:..:.|..||
Mouse   473 -KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEILYSLAL 536

  Fly   356 ------NLSGTQYSEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARD 411
                  .|:|.....|...|::|   :|:.|||||:|||.|:||..||...|.:::|..:....:
Mouse   537 AHARRSGLAGQYPLSDFALLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIIN 601

  Fly   412 ALRSLTNLTSGEFES--------CLELN---ISVCAFTQDTANNV-----IVTLVNPLAHSSTQY 460
            |..   .|..|:.|:        .|:::   :|..|..:.|...:     .|.:.|||.......
Mouse   602 AAH---YLVLGDQETYSFDPGTPFLQMDDSRVSHDALPERTVIRLDSSPRFVVVFNPLEQERLSV 663

  Fly   461 VRVPAKNENYIVTDEKGREV----------FSEVVPVPWQVL-----------ALEHRPNDTQHE 504
            |.:...:....|..|:|:.:          .:::||..:||.           .|:.:| |....
Mouse   664 VSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDMVPDVYQVSVPVRLPGLGLGVLQLQP-DLDGP 727

  Fly   505 LVFEASVDKIANFLIRV-LPSPKNIAEDQVQFP---VERSQDELTVETSLVKLTFDTTTGGLKTV 565
            ...::||        || |...|.....|..||   |:....:..:....:::.|...||.||::
Mouse   728 YTLQSSV--------RVYLNGVKLSVSRQSAFPVRVVDSGASDFAISNRYMQVWFSGLTGLLKSI 784

  Fly   566 KM--NGFTENIQQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDIEI---------VNNKVELSFY 619
            :.  ....:.::..|.:| |.|    .||:: ||||:|.|  |.|.         |....|..|:
Mouse   785 RRVDEEQEQQMELEFLVY-GTR----TSKDK-SGAYLFLP--DSEAKPYVPKKPPVLRVTEGPFF 841

  Fly   620 NGTKVKEVHQHVNEWISQVIRIYEDVNRVEFEWLVGPIPTD--DDVGKEIITRFSSNISSKGKFY 682
            :...|...|.|      ||||:| ::..||...|......|  |.|.||:..|..::|.|:|.|:
Mouse   842 SEVAVYYEHFH------QVIRLY-NLPGVEGLSLDMSFQVDIRDYVNKELALRIHTDIDSQGTFF 899

  Fly   683 TDSNGREILERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGEL 747
            ||.||.:|..|:..::   .|     :..|:||:.....:||.::|:||...:|.|.:||.:|:|
Mouse   900 TDLNGFQIQPRQYLKK---LP-----LQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQL 956

  Fly   748 ELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILD-------AVDGKPNQRLLQHQLDQH 805
            |::|.|||:.||..|:|:.|.:.:     |...:..|:|:       .|..:..:......|..|
Mouse   957 EVILDRRLMQDDNRGLGQGLKDNK-----ITCNRFRLLLERRTTMSPEVHQEQERSTSYPSLLSH 1016

  Fly   806 FWKFF----------SKSNGVASVNRNMIPDFFGIPESVELLSLE--------PYSKDQILIRLE 852
            ....:          :|..|.:...|:..|....:|....||:|.        |.:...:::..:
Mouse  1017 LTSMYLSTPPLVLPVAKRQGTSPALRSFHPLASPLPCDFHLLNLRMLPAEDTLPATDSALILHRK 1081

  Fly   853 NFN--TEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPH 915
            .|:  .|...:.||.              ||..|.:.|..:..   ..|.|...|:|:...:...
Mouse  1082 GFDCGLEAKNLGFNC--------------TTSQGKLALGSLFH---GLDVTFLQPTSLTLLYPLA 1129

  Fly   916 NPLTANSTMNASGFVVTLVPMQIRTF 941
            :|  :|||      .::|.||:|.||
Mouse  1130 SP--SNST------DISLEPMEISTF 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	102/298 (34%)
		Alpha-mann_mid	323..398	CDD:286360	33/84 (39%)
		Glyco_hydro_38C	536..941	CDD:285047	111/447 (25%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	294/1066 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810