Protein Alignment LManI and alpha-Man-IIb

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: XP_061507691.1
• Gene: alpha-Man-IIb / 1270912
• VectorBaseID: AGAMI1_000411
• Length: 1267
• Species: Anopheles gambiae
• Alignment Length: 1075
• Identity: 260/1075 - (24%)
• Similarity: 432/1075 - (40%)
• Gaps: 221/1075 - (20%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.:.:|||||:|.|||||...|:.....:        ||:..|.::.:..:..||..|..|...|
Mosquito   195 LKIVVVPHSHNDPGWLKTFVNYFQSDSRQ--------ILNLAVTKMPEYGNMSFIWSEISFLQLW 251

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.:...|.||.:||||..||||...|.|.|.|||..|..::|||...|.:::|.....  .|..|
Mosquito   252 WDQAHPTKQRILKKLVQSGRLEITTGGWVMTDEANAHLYAMVDQLIEGHQWVKANLNI--TPKTG 314

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDK----KQRMLDLEMEMIWQ------SSESLKN 186
            |.||||||...:..:.|...|.|....|:.|..|    :.|..|......|:      :|::..:
Mosquito   315 WSIDPFGHGSTVPYLLAASGFKGTIIQRIHYAWKQWFARHRYGDFLWTPYWKNPSDGGASQARAH 379

  Fly   187 SNIFTGMLYNHYSAP------PGFCFDINCEDAPIIDGESYD----------NNVDARVSEFIDY 235
            |.:...|.::.||..      |..|.:.:....|   ||..:          .|::|:....::.
Mosquito   380 SMLTHNMPFDIYSIKHSCGPHPFICLNFDFRKIP---GEYTEYSIKAQFITPENIEAKADLLMEQ 441

  Fly   236 VKNMSKSYRSTHIMVPMGDDFQY---EDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLY 297
            ....:..:.....::|:||||:|   ::....:.|..|||.|:|:.::. ....:.:.||..|..
Mosquito   442 YSRTASLFPHNVALIPVGDDFRYNKEKEMEQQYTNYKKLIDYINEHRAK-YNAEISFGTPVDYFN 505

  Fly   298 ELHQLKQTWPNKTEDFFPY----SSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLS 358
            .:.:....:|....|||.|    :....:||:||||:||..|...|:..|..::::.|..:|...
Mosquito   506 AIRERYDRFPTLKGDFFVYADIFNEGRPAYWSGYFTTRPYYKILSRELEHNLRSLEILFTIAFNR 570

  Fly   359 GTQ---------YSEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARD 411
            ..|         |.::.:.:..|   :|:.|||||:|||.|..|..||...||::|.........
Mosquito   571 ARQTGSSNAFKIYEKNYEKMILARRNLGLFQHHDAITGTSKANVMRDYALRLFESIQDTVKLQEK 635

  Fly   412 ALRSLT----------NLTSGEFESCLELNISVCAFTQDTANN------VIVT--------LVNP 452
            .:..|.          ....||.|             :|....      :|||        :.|.
Mosquito   636 TIELLVQRKPHDQQQHGFLIGELE-------------RDNFGKLPRKTPIIVTEGRSTDFIVYNA 687

  Fly   453 LAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHR-----PNDTQHELVFEASV- 511
            ||....:.|.:........:.|..|:.:..::.|| |.:....:.     |:|.::|::|.|.:
Mosquito   688 LAQERLEVVTIRTLTPRVKILDAAGKAIDIQINPV-WNITETSYTSRKIVPSDKEYEVMFVARLA 751

  Fly   512 -----------------DKIANFLIRVLPSPKNIAEDQVQFPVERSQ-DELTVETSLVKLTFDTT 558
                             .|:|..........|..|     |.|...| .::.:|...::|.||..
Mosquito   752 PLSLTTYTAAYDEDGYQGKMATLYCTECQDEKTKA-----FEVRTKQPGDIQLENYKMRLLFDEQ 811

  Fly   559 TGGLKTVKMNGFTENIQQT--FGIYKGYRGNNG------ESKNRSSGAYVFRPYGDIEIVNNKVE 615
            :|.||:|......:.||..  |..||..:.::|      :.:.|:|...|...|.|:.|:
Mosquito   812 SGFLKSVTKKHMGKQIQCAIKFAAYKSAQFHSGAYLFKTDPEQRNSEKDVLEQYSDMTIL----- 871

  Fly   616 LSFYNGTKVKEVHQHVNEWISQVIRIYED----------VNRVEFEWLVGPIPTDDDVGKEIITR 670
              ..:|....:|......:::..:|||..          .|.::||  ..|...:.::....:|.
Mosquito   872 --ITSGPLASDVTAIYGPFLAHTVRIYNSNSVLDSAIYIENDIDFE--APPKNRETELFMRFVTD 932

  Fly   671 FSSNISSKGKFYTDSNGREILERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDR 735
            ..:..|...:||:|.||.:..:|.:..        :..:.|||:|:|....:|||..|:|||...
Mosquito   933 IENGASENPEFYSDLNGFQYQKRVKVS--------AIGVEGNYFPITSGAFIQDDRMRLTLLTTH 989

  Fly   736 AQGGTSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLIARGKIYLILDAVDGK-------- 792
            |||..||:.|:||:||.||.|.||..|:||.:.:::     :.|.:.:|.|:.:|.:
Mosquito   990 AQGAASLEPGQLEVMLDRRTLYDDYRGMGEGVIDSR-----LTRHRFWLTLETIDAQQSPNVEPA 1049

  Fly   793 -PN-QRLLQHQLDQHFWKFFSKSNGVASVNRNMIPDFF------GIPESVELLSLEPYSK-DQI- 847
             || |...:.|..|      .|.:...:.:...:|..|      |:.....|..:|.|.: :|:
Mosquito  1050 APNGQEEREPQQQQ------QKESSTTTSDPYQLPSIFANALANGLNYPANLFIVERYDESNQLE 1108

  Fly   848 ------LIRLE--------NFNTEGNVVSFNIYPLFESLDGY-----QIWETTLDGNMLLEDVKR 893
                  |:|::        |..|    ::.|..|||.|....     |.:...:.|.   |.:..
Mosquito  1109 LNRAVRLLRVQFPCDLHMLNLRT----LTENNLPLFPSSSALLVLQRQGYSCRIGGE---ETIAY 1166

  Fly   894 FKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASG 928
            |    .|.||..||.....:..||.. |:.::..|
Mosquito  1167 F----CGNGSSSSSSSGSSSTSNPAN-NAVIDGGG 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	84/302 (28%)
		PLN02701	4..765	CDD:178304	219/871 (25%)
alpha-Man-IIb	XP_061507691.1	None