Protein Alignment LManI and man2a2

DIOPT Version :9

• Sequence 1: NP_001260350.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: XP_009296075.1
• Gene: man2a2 / 100333987
• ZFINID: ZDB-GENE-110331-1
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1110
• Identity: 288/1110 - (25%)
• Similarity: 450/1110 - (40%)
• Gaps: 276/1110 - (24%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.:|||||:|.||:||.|:||   .::.||     ||:.:|.::.:|..|:||..|..:||||
Zfish   166 LQVFVVPHSHNDPGWIKTFDKYY---NDQTQH-----ILNNMVTKMAEDPRRKFIWSEISYFAKW 222

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.......|..::||:..|:||...|.|.|.|||..||.:::||...|.::|:...|  ..|..|
Zfish   223 WESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLG--VTPRSG 285

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKNS-NIFTGML- 194
            |.:||||||..|..:..:...:.....|:.|..||.......:|.:|:.:..:::| ::|..|:
Zfish   286 WAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMMP 350

  Fly   195 YNHYSAP------PGFC--FD--------INCEDAP--IIDGESYDNNVDARVSEFIDYVKNMSK 241
            :..|..|      |..|  ||        :||   |  :......|.||..|....:|..:..||
Zfish   351 FYSYDVPHTCGPDPKICCQFDFKRLPGSRVNC---PWKVPPRAINDANVAERAGVLLDQYRKKSK 412

  Fly   242 SYRSTHIMVPMGDDFQYEDAA---VNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLK 303
            .:||..::||:||||:|:.|.   ..:.|..||..|:|....  ..|...::|.|.|...:::..
Zfish   413 LFRSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPE--MHVKAQFATLSDYFDAVYKAN 475

  Fly   304 --------QTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVL------ 354
                    ..:|..:.|||.|:.....||:||:||||..|...|......:..:.|..|
Zfish   476 GVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLAVAHAR 540

  Fly   355 -ANLSGTQYSEDLDNLSQA---MGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAE----NSA-- 409
             |.:.|.....|...|:.|   :|:.|||||:|||.|:||..||...|.:::||.:    |:|
Zfish   541 HAGVEGRYPVSDYSLLTDARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIINAAHF 605

  Fly   410 -----RDALR------------------SLTNLTSGEFESCLELNISVCAFTQDTANNVIVTLVN 451
                 :|..|                  ||...|..|.||                :...:.|.|
Zfish   606 LIIKNKDIYRFYQTEPFLETDDRRATQDSLPQRTLIELES----------------SPRYLVLFN 654

  Fly   452 PLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIAN 516
            |:.......|.|...:....|..|.|:       .:|.|:.|......:...| |::||
Zfish   655 PVEQERLCLVTVLVNSARVRVLTEDGQ-------TLPVQLSAQWMSATEMSGE-VYQAS------ 705

  Fly   517 FLIRVLP--------------SPKNI-AEDQVQFPVE----RSQDELTVETSLV----------- 551
            |:.| ||              ||..: :|..::.|..    |..|.|.|.:..|
Zfish   706 FMAR-LPALGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQS 769

  Fly   552 -KLTFDTTTGGLKTVKMNGFTE--NIQQTFGIYKGYRGNNGESKNRSSGAYVFRPYGDIEIVNNK 613
             .|.|...||.|::::.....:  .:|..|..| |.|    .||:: ||||:|.|.|:.:..:.:
Zfish   770 LTLGFSGATGLLESIRRKDDPQEVRVQIQFLTY-GTR----PSKDK-SGAYLFLPDGNAKPYSQR 828

  Fly   614 VE--LSFYNGTKVKEVHQHVNEWISQVIRIYE--DVNRVEFEWLVGPIPTDDDVGKEIITRFSSN 674
            ..  :....|....||..|...: .|.:||:.  .|:.:..: :...:...|...||:..||.::
Zfish   829 EAPIVRVVEGPLFAEVVAHYQHF-QQTVRIHNVPGVDGLSLD-ITTMVDIRDQNNKELAMRFVTD 891

  Fly   675 ISSKGKFYTDSNGREILERERNQREHFTPDMSEAISGNYYPVTGQISLQDDEKRITLLNDRAQGG 739
            |.|...||||.||.:|..|...|:   .|     :..|:||:.....:||.:.|:||...:|.|.
Zfish   892 IQSGDTFYTDLNGFQIQPRRYFQK---LP-----LQANFYPMPSTAYIQDSQYRLTLHTAQALGV 948

  Fly   740 TSLKDGELELMLHRRLLNDDAFGVGEALNETQ----------------------YG-------TG 775
            |||..|:||::|.|||:.||..|:|:.|.:.:                      |.       .|
Zfish   949 TSLASGQLEVILDRRLMQDDNRGLGQGLKDNKRTANRFRLLLERRSNSAKPAGSYANMLNKIIAG 1013

  Fly   776 LIARGKIYLILDAVDGKP----------NQRLLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFGI 830
            ::..|:    .:.||.:|          ...:|.|::  .......:.:||..: |...|....:
Zfish  1014 ILGDGQ----EEPVDSRPVSFPSLLSHMTSTILNHEV--LALPVLPRKHGVPPM-RTFAPLAGTL 1071

  Fly   831 PESVELLSLEPYSKDQ-----------ILIRL----------ENFN---TEGNVVSFNIYPLFES 871
            |....||:|......|           :|.||          ..||   |:|.:   ::..||..
Zfish  1072 PCDFHLLNLRSIQSPQDAHSPSPYMALLLHRLGLDCGLEPQNPGFNCTTTQGQL---SVSGLFRG 1133

  Fly   872 LDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMNASGFVVTLVPM 936
            ||           ..||:               |.|:...|: ..||:.:|:       |:|.||
Zfish  1134 LD-----------LQLLQ---------------PMSLSLMHS-QPPLSNDSS-------VSLEPM 1164

  Fly   937 QIRTF 941
            :|..:
Zfish  1165 EISAY 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	96/296 (32%)
		Alpha-mann_mid	323..398	CDD:286360	31/84 (37%)
		Glyco_hydro_38C	536..941	CDD:285047	116/489 (24%)
man2a2	XP_009296075.1	PLN02701	128..1173	CDD:178304	288/1110 (26%)
		CE4_SF	165..508	CDD:301698	109/356 (31%)
		Alpha-mann_mid	503..588	CDD:214875	31/84 (37%)
		Glyco_hydro_38C	741..1169	CDD:285047	115/487 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910