DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and man2b2

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001106515.1	Gene:	man2b2 / 100127706	XenbaseID:	XB-GENE-1006292	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	1058	Identity:	284/1058 - (26%)
Similarity:	449/1058 - (42%)	Gaps:	208/1058 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            |...::||||.||||:.||.:        ..||....:..||||||::...||||.||..||..|
Frog    22 IQAFVIPHSHMDVGWVYTVQE--------SMHAYAANVYTTVVEELMRGDRRRFIVVEQEFFRLW 78

  Fly    67 YSEQTETVQR-AVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            :......|:: .|.:|:.:|||||..|...|:|||.......:.|...|..::.:|||  .||..
Frog    79 WKLFAGNVEKQQVHQLMREGRLEFVIGGQVMHDEALTTIDDQILQLTEGHGFIYETFG--VRPRF 141

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKN-SNIFTGML 194
            .|.:||||.|....::||...|||...:|:||..|.......|::.||::|.||.: ..|||.::
Frog   142 SWHVDPFGASAASPTLFAMAGFNGHLISRIDYDTKADMQNGKELQFIWRASPSLSDKQEIFTHVM 206

  Fly   195 ---------YNHYSAPPGFCFD-INCEDAPIIDGESYDNNVDARVSEFIDYVKNMSKS------- 242
                     |..:|...||.:: |.....|..||...:.::.........|.:.|.|:
Frog   207 DQYSYCTPSYIPFSDRSGFYWNGIAVFPDPPKDGMYPNMSLPVTADTIHPYAETMVKNIKERAAW 271

  Fly   243 YRSTHIMVPMGDDFQYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTWP 307
            :||:.::.|.|.|.|:.:|:|.|.|||.|:.|:|.....|  |.|.|||...|...|:....||.
Frog   272 FRSSDVLWPWGCDKQFFNASVQFNNMDLLLDYINKHTEFG--VTVQYSTLGDYFKNLYNRNLTWG 334

  Fly   308 NK-TEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQL---SVLANLSGTQYS----E 364
            .: ::||.||||||...|||::|||...|...|..:......:..   .:|.:.:|:...    |
Frog   335 LRGSQDFLPYSSDSSQAWTGFYTSRNVLKGVARRASSLLYAAESAFAQHLLKHPTGSVEKVWAME 399

  Fly   365 DLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDALRSLT-NLTSGEFESCL 428
            .|.:|..|:..:||||.:||||...|...|...|.:...|    .|..:.::. :|.|.:..||
Frog   400 QLRSLRWAVSEVQHHDGITGTESPKVRDMYIANLLQGAAG----VRKLMAAIVMDLYSSQANSC- 459

  Fly   429 ELNISVCAFTQDTANNVI-VTLVNPLAHSSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVL 492
                         .|..| :|:.||||...|.:|.||..|....|.|:.|:       |||.|:
Frog   460 -------------GNGYINITVYNPLAWDVTTFVLVPMNNSVSGVYDKFGQ-------PVPAQI- 503

  Fly   493 ALEHRPNDTQHELVFEASVDKIANFLIRVLPSPKNIAEDQVQFPV---ERSQDELTVETSLVKLT 554
                 .|.|:....|:          :.:|.:.|.::..:....:   :.:.|.|....   |:|
Frog   504 -----QNATEPSNAFD----------LHILVTLKGLSYGRYSIKLGSCDAANDRLVTGR---KIT 550

  Fly   555 F---------------------------DTTTGGLKTVKMNGFTENIQQTFGIYKGYRGNNGESK 592
            |                           |..|..|.::......:.:|.|....: |..|...||
Frog   551 FVRQPKRNKAKRQNLVTPIMNDCYTVVIDQNTNLLHSITARESNQTVQVTQEFLE-YHSNGDISK 614

  Fly   593 NRSSGAYVFRPYGDIEIVNNKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNR---------- 647
            ...|..|:|...|........|.|....|..|.|:.|:....|:....:|...:|
Frog   615 GPISDNYLFTSTGPAISAYKAVGLEIIAGKLVTEIRQYFYSNITAQTYLYAVYSRIYNVPEGYDK 679

  Fly   648 ------VEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMS 706
                  :|..:.|||:    |:.:|.|.|.|:::.:....|||:||.::      ||..|....:
Frog   680 SLVCHHIEQSYRVGPM----DLNRESIIRTSTDLRTDRLIYTDNNGYQM------QRRQFKNYDT 734

  Fly   707 EAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAFGVGE--ALNE 769
            ..::.||||:.....::|:..|:..|::||.|.:|..:||:|:||||||.|:..:.:..  .||:
Frog   735 NTVARNYYPMVRTAYIEDNSTRLVFLSERAHGVSSQDNGEVEIMLHRRLWNNLEWDLNYNLTLND 799

  Fly   770 TQYGTGLIARGKIYLILD--AVDGKPNQRL---LQHQLDQHFWKFFSKSNG--VASVNRNMIPDF 827
            |.     :.|..|:|:|.  |:.|...|||   |:|:.    ...:|...|  ..|.....:|
Frog   800 TS-----VVRPTIWLMLGSRALAGALYQRLGMALEHRP----LVIYSLHTGQEKRSYKTTDLP-- 853

  Fly   828 FGIPESV--ELLSLEP--YSK---------------------DQILIRLEN-FNTE-----GNVV 861
            ..:|:::  ::||:..  ||.                     .::|:||:: :.|.     ...|
Frog   854 ITLPDNIHLQILSIPGWFYSSRHHEHMQDIHTGNIRDNVADFHRVLLRLQHLYETNEDPVLSKPV 918

  Fly   862 SFNIYPLFESLDGYQ-IWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANSTMN 925
            :.|:..|.:.|.... :.|.:|.|...:..:||:|:    ..:|..:.:..|          |:.
Frog   919 TINLQSLLKGLGTVSLVEERSLTGTWDIHTLKRWKW----KANIKGTDQREH----------TLG 969

  Fly   926 ASGFVVTLVPMQIRTFII 943
            .|.|.:||.|.:|||..:
Frog   970 TSDFTITLSPKEIRTLFV 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	97/292 (33%)
		Alpha-mann_mid	323..398	CDD:286360	24/81 (30%)
		Glyco_hydro_38C	536..941	CDD:285047	112/491 (23%)
man2b2	NP_001106515.1	GH38N_AMII_Epman_like	22..346	CDD:212122	112/335 (33%)
		Alpha-mann_mid	352..433	CDD:214875	24/80 (30%)
		Glyco_hydro_38C	567..985	CDD:285047	107/453 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020