Protein Alignment LManI and man2a1

DIOPT Version :10

• Sequence 1: NP_609407.1
• Gene: LManI / 34436
• FlyBaseID: FBgn0032253
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001163963.1
• Gene: man2a1 / 100036612
• XenbaseID: XB-GENE-961025
• Length: 1150
• Species: Xenopus tropicalis
• Alignment Length: 1074
• Identity: 294/1074 - (27%)
• Similarity: 475/1074 - (44%)
• Gaps: 224/1074 - (20%)

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            :.|.||||||:|.|||||.|.|:   :::.||     ||:.:|.:|.:|.:|:|:..|..:|:||
 Frog   168 LQVFLVPHSHNDPGWLKTFDDYF---RDQTQH-----ILNNMVIKLQEDKNRKFMWSEISYFSKW 224

  Fly    67 YSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTVG 131
            :.......:.|||:|:...:.|...|.|.|.||||.||.|:|||...|.::|:...|  .:|..|
 Frog   225 WDGIDNQKKEAVKRLIELEQFEIVTGGWVMPDEATPHYFSLVDQLIEGHQWLEKNLG--VKPKSG 287

  Fly   132 WQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKNS-NIFTGML- 194
            |.|||||||..||.|......:.....|:.|..||.......:|..|:.:..|.:| :|...|:
 Frog   288 WAIDPFGHSPTMAYILKSSGLSNMLIQRVHYSIKKYFASKQTLEFFWRQNWDLGHSTDILCHMMP 352

  Fly   195 YNHYSAP------PGFC--FD--------INCE---DAPIIDGESYDNNVDARVSEFIDYVKNMS 240
            :..|..|      |..|  ||        ::|.   ...:|:    :.||..|....:|..:..|
 Frog   353 FYSYDVPHTCGPDPKICCQFDFKRLPGSRVSCPWRVPPEVIN----EGNVQHRAWMILDQYRKKS 413

  Fly   241 KSYRSTHIMVPMGDDFQYEDAA---VNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQL 302
            |.||:..::||:||||:|.|:.   ..::|..||..|:|.....  .|...:.|.|.|...|.:.
 Frog   414 KLYRTKVLLVPLGDDFRYTDSLEWDQQYENYQKLFSYMNSHPEL--HVKAQFGTISDYFKALRKA 476

  Fly   303 -------KQTWPNKTEDFFPYSSDSHSYWTGYFTSRPTQKRFHR---------DGNHFFQTVK-- 349
                   .|::|..:.|||.|:.....||:|||||||..||..|         :..:.|..|:
 Frog   477 GNVDDPNSQSFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRLERVMESHLRAAEILYSFALVQMN 541

  Fly   350 QLSVLANLSGTQYSEDLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAENSARDALR 414
            :...|.:....::.:.|....:.:|:.|||||:|||.|..|..||...||.:::..:....||..
 Frog   542 KFDKLQSFPSVEHYKLLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMNLKRVIIDAAH 606

  Fly   415 SLT---------NLTSGEFESCLELNISVCAFTQDTANNV-----IVTLVNPLAHSSTQYVRVPA 465
            .|.         | .|..|.|..::..|..:..|.|...:     .:|:.||........|.|..
 Frog   607 VLVLKDKDTYAYN-PSSPFFSMDDVQPSQDSLPQKTVIKITEIPRYLTVYNPTEQERYSVVSVYV 670

  Fly   466 KNENYIVTDEKGREVFSEVVPVPW-----------QVLALEHRP--NDTQHELVFEASVDKI-AN 516
            .:....|....|:.:.:::..| |           ||..|.:.|  ....::||...:.:.| |:
 Frog   671 SSSKVKVISASGKALKAQISAV-WNGDSAPLQDMYQVSFLAYLPALGLAVYKLVEAENSESIKAD 734

  Fly   517 FLIRVLPSPKNIAED------QVQFPVERSQDELTVETSLVKLTFDTTTGGLKTV--KMNGFTEN 573
            :.|.|....|||..|      :|...|    .::|:|.:.:||.| :::|.|:.:  |.:|.|..
 Frog   735 YTIFVQGKHKNINSDGNFRIKEVNIVV----GDVTIENTYLKLWF-SSSGLLEKIQSKEDGKTHG 794

  Fly   574 IQQTFGIYKGYRGNNGESKNR-SSGAYVFRPYGDIEIVNNK----VELSFYNGTKVKEV---HQH 630
            ::..|..|       |.:.|| .||||:|.|.|:.:...|.    |.::  :|:...||   .:|
 Frog   795 VKVDFIWY-------GTTNNRDKSGAYLFLPDGEAKPYINADPPVVRVT--HGSIFSEVVVFFKH 850

  Fly   631 VNEWISQVIRIYEDVNRVEFEWLVGPIPTDDDV-------GKEIITRFSSNISSKGKFYTDSNGR 688
                ::..:|:| :|:.:|     |..|...:|       .:||:.|.:|:|:||.:||||.||.
 Frog   851 ----LTHTVRLY-NVHGLE-----GQSPEITNVVDIRGEFNREIVMRITSDINSKHRFYTDLNGY 905

  Fly   689 EILERERNQREHFTPDMSE-AISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLH 752
            :|..|.         .:|: .|..|.||:|....:|||..|:||.:.::.|..|.|.|:||:.|.
 Frog   906 QIQPRR---------TLSKLPIQANVYPMTSMAYIQDDASRLTLHSAQSLGVASSKSGQLEVFLD 961

  Fly   753 RRLLNDDAFGVGEALNETQYGTGLIARGKIYLILD---AVDGKPNQRLLQH-QLDQHFWKFF--- 810
            |||:.||..|:|:.:.:.:..:.|..     |:|:   ..|.|.:::.:.: .:..|....|
 Frog   962 RRLMQDDNRGLGQGVQDNKITSNLFR-----LLLEKRFGKDEKEDEKPVSYPSILSHITSMFLNH 1021

  Fly   811 ------SKSNGVASVNRN-MIPDFFGIPESVELLSLE-------PYSKDQ--ILIRLENFN---- 855
                  :.|:..:||..| .:|....:|..|.||:|.       |...|:  :::..:.|:
 Frog  1022 PVIPMAATSDSGSSVLLNAFLPLTSSMPCDVHLLNLRTIQAKVGPIPSDEAALILHRKGFDCKFS 1086

  Fly   856 ----------TEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEY 910
                      |:|.|   :::.||   :|:.|                       ...||||:..
 Frog  1087 NKDLGLLCSTTQGKV---SVHRLF---NGFNI-----------------------ESLIPSSLTL 1122

  Fly   911 YHAPHNPLTANSTMNASGFVVTLVPMQIRTFIIQ 944
            .|:..|  :.|:|      .:.:..|.|:||.|:
 Frog  1123 MHSSSN--SKNTT------EIRISTMDIKTFRIK 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_609407.1	GH38N_AMII_LAM_like	2..276	CDD:212121	100/297 (34%)
		PLN02701	4..765	CDD:178304	253/854 (30%)
man2a1	NP_001163963.1	PLN02701	130..1150	CDD:178304	294/1074 (27%)