DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and man2b2

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_001337519.3	Gene:	man2b2 / 100003570	ZFINID:	ZDB-GENE-140106-166	Length:	1006	Species:	Danio rerio

Alignment Length:	1065	Identity:	272/1065 - (25%)
Similarity:	456/1065 - (42%)	Gaps:	206/1065 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 INVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAKW 66
            |...::||||.||||:.||.:        ..||....:..||||||.:..:|:||.||..||..|
Zfish    23 IQAFVIPHSHMDVGWVYTVQE--------SMHAYASNVYSTVVEELTRVKNRKFIAVEQEFFRLW 79

  Fly    67 YSE-QTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            ::. .::..::.|::|:.:|||||..|...|:|||.......:.|...|..:|.:|||  .||..
Zfish    80 WTNVASDWHKKQVRQLLLEGRLEFIIGGQVMHDEAVTDVDDAILQLTEGHGFLYETFG--VRPRF 142

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLK-NSNIFTGML 194
            .|.:||||.|.....:||...|:....:|:||..|.....:.:::.:|:.|.:|| ...|||..:
Zfish   143 AWHVDPFGASATTPVLFALAGFDAHLISRIDYDLKDDMQKNKKLQFVWRGSPTLKEKQEIFTHTM 207

  Fly   195 ---------YNHYSAPPGFCFD-INCEDAPIIDGESYDN--------NVDARVSEFIDYVKNMSK 241
                     |..:|...||.:: :.....|..||: |.|        .|:......:|.::..::
Zfish   208 DQFSYCTPSYIPFSNRSGFYWNGVALFPDPPKDGK-YPNMSLPVTKETVELYAQTMVDNIRLRAQ 271

  Fly   242 SYRSTHIMVPMGDDFQYEDAAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTW 306
            .:||:|::.|.|.|.|:.:|:|.|.|||.|:.|:| ..|....|.|.|:|...|...|||...:|
Zfish   272 WFRSSHVLWPWGCDKQFYNASVQFSNMDVLMNYIN-THSDQYGVTVQYATLKDYFQTLHQTNLSW 335

  Fly   307 PNK-TEDFFPYSSDSHSYWTGYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLS---GTQYSE--- 364
            ..: .:||.|||::....|||::.||...|...|..:......:.|....::|   |....|
Zfish   336 DVRGNQDFLPYSTEPFQAWTGFYGSRNVLKGVARRASSLLYASESLFTRYHISYPDGPVQREWAL 400

  Fly   365 -DLDNLSQAMGIMQHHDAVTGTEKQAVASDYDRLLFKAIVGAE--------------NSARDALR 414
             .|..|..|:..:||||.:||||...||..|...|.:.::|||              |...|.::
Zfish   401 SKLKALRWAVSEVQHHDGITGTESPKVADMYMEHLLQGMMGAEELLAAIFLLPQTLSNDIYDQIK 465

  Fly   415 SLTNLTSGEFESCLELNISVCAFTQDTANNVIVTLVNPLAHSSTQYVRVPAKNENYIVTDEKGRE 479
            :.......:.|:..|.:|.|               .||||.:.:.||.|..:....:|.|:.|:.
Zfish   466 NTPTTARTDSENVPEQHIFV---------------YNPLAWNISTYVNVSVQYAMAVVLDDDGKA 515

  Fly   480 VFSEVVPVPWQVLALEHRPNDTQHELVFEASVD--KIANFLIRVLPSP---------KNIA---- 529
            |.:::.|      ::|   :.|.::|.|...:.  :...:.::...||         .::|
Zfish   516 VPAQIQP------SME---SSTVYDLFFVVELGGLQYRKYTVQFPQSPCDTGSACGATHVAKVVK 571

  Fly   530 --EDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTV--KMNGFTENIQQTFGIYKGYRGNNGE 590
              :..|:...:..:..|.|.....||.||..|..|.::  :.......:||.|..||.    ||:
Zfish   572 FNKTNVRQWKKTGRKLLPVLNECYKLMFDQETNLLHSITDRSKKIRVRVQQDFWEYKA----NGD 632

  Fly   591 SKNRS-SGAYVFRPYGDIEIVNNKVELSFYNGTKVKEVHQH-------VNEWISQVIRIYEDVN- 646
            .::.. |..|:|...|........|.:....|..:.|:.|:       .|...|.|.|:.....
Zfish   633 VQSGPISDNYIFTANGSAVPAYKSVVMEIVPGKVISEIRQYFYREEEDANHTYSVVTRVPVGFKG 697

  Fly   647 -----RVEFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMS 706
                 |:|..:.|||:    :|.:|.:.|..:::.:....:||:||.::::|.      :....:
Zfish   698 RLSCFRLEQSYKVGPL----EVNRETVFRTRTSLQNNRTLFTDNNGYQMMKRT------YKGYAN 752

  Fly   707 EAISGNYYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAF--GVGEALNE 769
            ..::.||||:.....::|:..|:..|::||.|..||..|:||:||||||.|:..:  |....||:
Zfish   753 NTVARNYYPMVRVAYMEDESSRVVFLSERAHGVASLSQGQLEVMLHRRLWNNQEWNQGYNLTLND 817

  Fly   770 TQYGTGLIARGKIYLILDAVDG-----KPNQRLLQHQ-----LDQHFWKFFSKSNGVASVNRNMI 824
            :.     :.|..::::|.:.|.     :.....|||:     :||            .....|..
Zfish   818 SS-----VVRPVLWMMLGSPDSLSSIYQQEAVELQHRPVVMAIDQ------------PQKLLNQR 865

  Fly   825 PDFFG-------IPESVELLSLE----PYSK--------------DQILIRLENFNTEGN--VVS 862
            ..|.|       :|:::.:.||.    .||.              |:||:|:.:...||.  |:|
Zfish   866 ETFSGPSVHPVVLPQNLHMQSLSIPGWNYSPEHSSGGDEKSEVNFDRILLRITHLYEEGESPVLS 930

  Fly   863 ----FNIYPLFESLDGY-QIWETTLDGNMLLEDVKRFKFAQDGTGSIPSSVEYYHAPHNPLTANS 922
                .|:..:.:.:... ::.|.:|.|...:.|::|:.:..|.|                :....
Zfish   931 QPTTINLKEVMQGIGKVSKVQECSLTGTWNISDLQRWNWKTDET----------------MQKTD 979

  Fly   923 TMNASG----FVVTLVPMQIRTFII 943
            ....||    |.||:.|.:||||.|
Zfish   980 KSGFSGVTQDFNVTISPKEIRTFFI 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	93/293 (32%)
		Alpha-mann_mid	323..398	CDD:286360	25/81 (31%)
		Glyco_hydro_38C	536..941	CDD:285047	105/468 (22%)
man2b2	XP_001337519.3	PLN02701	20..1002	CDD:178304	269/1061 (25%)
man2b2	XP_001337519.3	GH38-57_N_LamB_YdjC_SF	23..348	CDD:330225	108/336 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920