DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loh and ADAMTS1

DIOPT Version :9

Sequence 1:NP_609406.2 Gene:loh / 34435 FlyBaseID:FBgn0032252 Length:880 Species:Drosophila melanogaster
Sequence 2:NP_008919.3 Gene:ADAMTS1 / 9510 HGNCID:217 Length:967 Species:Homo sapiens


Alignment Length:758 Identity:165/758 - (21%)
Similarity:258/758 - (34%) Gaps:240/758 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LLIFSILTILATIHDSS-----FVQADLTTKERIKKHQDWLREHRKPKTKKKISINSYYELANLW 64
            |::..||    .|||..     ...|.||    ::...:|.::|..|..:..    .:|:.|.|:
Human   304 LVVVKIL----VIHDEQKGPEVTSNAALT----LRNFCNWQKQHNPPSDRDA----EHYDTAILF 356

  Fly    65 HTRKDLSSPKQ-------------KPNNKEEYLENE-------TTSKISNKSDEKVLKSSTIISL 109
             ||:||...:.             .|:.....:|::       |..::.:..:.....:....||
Human   357 -TRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL 420

  Fly   110 NATNPSTSTFKSVLET-------TTLPSVTTKDLFESGNVATTRQTPKVEEVFSSPNPPQ----- 162
            |..|..:....|:|..       :...:.......::|:.......|:        ||.|     
Human   421 NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ--------NPIQLPGDL 477

  Fly   163 -----------------------EATSSTS----------------------------------- 169
                                   :|.|:.|                                   
Human   478 PGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCIN 542

  Fly   170 ----KKAKKKVYPYP---RWDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNA---CVG 224
                .|..:|.:..|   .|..|..|..|||:|||||:|.:|:|       :|.:..|.   |.|
Human   543 GKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMREC-------DNPVPKNGGKYCEG 600

  Fly   225 YFKRYQLCNDVPC-DEQSPDFRASQCSAYNDKEF------HGHRYRWEPY---VKDDAECELNCM 279
            ...||:.||...| |.....||..||.|:|  ||      .|....|.|.   |.....|:|.|.
Human   601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHN--EFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQ 663

  Fly   280 PFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG- 343
            ..|:..|..|...|:|||||...:         .:|||.|.|........||..........|| 
Human   664 AKGIGYFFVLQPKVVDGTPCSPDS---------TSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGG 719

  Fly   344 -GLLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITE-----LKNSINLLVLRTSNELAIFNG 402
             |..|:.::|..|.   .:..|..:.|:|.||:||.:.:     .:|:.:.|.::.::...|.||
Human   720 NGSTCKKISGSVTS---AKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNG 781

  Fly   403 ENTVS---ESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFT-KSANNTGVKY 463
            :.|:|   :...|:  |.|..|      ..|:...|.|.|..|:::.|.:.|.| .:|....:||
Human   782 DYTLSTLEQDIMYK--GVVLRY------SGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKY 838

  Fly   464 EYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFN-------WKVIGFSSCTKS 521
            .|.:....||                                  ||       |.:..:..|:||
Human   839 TYFVKKKKES----------------------------------FNAIPTFSAWVIEEWGECSKS 869

  Fly   522 CGGGTQTPIIRC--IRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSS 584
            |..|.|..::.|  |...|     ...|...|||.   :...|...||| .|:..:|..|..:..
Human   870 CELGWQRRLVECRDINGQP-----ASECAKEVKPA---STRPCADHPCP-QWQLGEWSSCSKTCG 925

  Fly   585 GGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCECPKN 627
            .|.::|.:.|:.. ..|::.|       |...|::|    ||:
Human   926 KGYKKRSLKCLSH-DGGVLSH-------ESCDPLKK----PKH 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lohNP_609406.2 TSP1 182..238 CDD:214559 23/59 (39%)
ADAM_spacer1 348..468 CDD:283607 32/128 (25%)
TSP1 667..716 CDD:214559
TSP1 779..835 CDD:214559
PLAC 847..877 CDD:285849
ADAMTS1NP_008919.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Pep_M12B_propep 66..166 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..250
Cysteine switch. /evidence=ECO:0000250 196..203
Reprolysin 258..467 CDD:279729 29/175 (17%)
ZnMc_ADAMTS_like 258..463 CDD:239801 29/171 (17%)
ADAM_CR 468..548 CDD:301627 6/87 (7%)
TSP1 562..614 CDD:214559 22/58 (38%)
Spacer 725..849 34/168 (20%)
ADAM_spacer1 725..842 CDD:283607 32/127 (25%)
TSP1 858..910 CDD:214559 16/59 (27%)
TSP1 912..967 CDD:214559 13/57 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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