DRSC/TRiP Functional Genomics Resources

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Protein Alignment loh and ADAMTS3

DIOPT Version :9

Sequence 1:NP_609406.2 Gene:loh / 34435 FlyBaseID:FBgn0032252 Length:880 Species:Drosophila melanogaster
Sequence 2:NP_055058.2 Gene:ADAMTS3 / 9508 HGNCID:219 Length:1205 Species:Homo sapiens


Alignment Length:683 Identity:182/683 - (26%)
Similarity:273/683 - (39%) Gaps:164/683 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNA---CVGYFKRYQLCNDVPCDEQSPD 243
            |..|:.:.||||:||.||:::.|:|       ||.:..|.   |.|....|||||...|.:...|
Human   554 WGSWTKFGSCSRTCGTGVRFRTRQC-------NNPMPINGGQDCPGVNFEYQLCNTEECQKHFED 611

  Fly   244 FRASQCSAYNDK-EFHGHRYRWEPYVKDDAE--CELNCMPFGMKSFATLNESVIDGTPCGHPAEY 305
            |||.||...|.. |:...::.|.||...|.:  |.|.|........|.:.:.|.|||.|.:...|
Human   612 FRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPY 676

  Fly   306 FRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCGG--LLCRPVTGIFTRNPLPEHAYIHVT 368
                    ::||.|.|..|....||...........|||  ..||.|.|.|||.| .:..|:.:.
Human   677 --------SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTP-RKLGYLKMF 732

  Fly   369 TLPVGASNISITELKNSINLLVLRTSNELA---IFNGENTVSESGSYEAVGAVFDYHRIDGAEDS 430
            .:|.||.::.|.|.:.|.::|.::  |:..   |.||:...::|.::..:|..:||:..|..|. 
Human   733 DIPPGARHVLIQEDEASPHILAIK--NQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIES- 794

  Fly   431 NGVTEWITSIGPIRDSLQLMVFTKSANNT--GVKYEYMLPIVSESEENEMSLESSDGLLRSGMED 493
                  :.:.||:.|.:.:::..:. |:|  .:.|:|::      .|:.:...:|:.:::..: |
Human   795 ------LHTDGPLHDPVIVLIIPQE-NDTRSSLTYKYII------HEDSVPTINSNNVIQEEL-D 845

  Fly   494 TSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNEN 558
            |             |.|.:..:|.|:|.||||.|.....|.||:..:...:..|..:.||.....
Human   846 T-------------FEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR 897

  Fly   559 LLHCNTQPCP-AYWRFDDWGEC--RCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQK 620
            :  ||.|.|. ..|..::|..|  .|.|| |.:.|.|.|:|.|..|....|....||.|:|..::
Human   898 M--CNIQECTHPLWVAEEWEHCTKTCGSS-GYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRR 959

  Fly   621 QCE---CPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVE 682
            .|.   ||                                    |.|....|:: ||||||.|.|
Human   960 PCNRVPCP------------------------------------AQWKTGPWSE-CSVTCGEGTE 987

  Fly   683 YRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACE----LGD--------------WFTGPWSSCN 729
            .|.|.|   :||: .|| ...|||.|.|:.|.|.    |||              ...|....|.
Human   988 VRQVLC---RAGD-HCD-GEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCC 1047

  Fly   730 GDC--------------------------FDLTRTREVLCIRSQLITEHSECTPELKPQSVEKCS 768
            ..|                          .||.|:   |.:.:.|:..||| ||      .:|.|
Human  1048 ESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRS---LVMPTSLVPYHSE-TP------AKKMS 1102

  Fly   769 HEEVEYCAARWHYSDWSECTKPCGGGTQRRSVR 801
            ...:........|:.:...:||.|...::||.:
Human  1103 LSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQ 1135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lohNP_609406.2 TSP1 182..238 CDD:214559 22/58 (38%)
ADAM_spacer1 348..468 CDD:283607 32/124 (26%)
TSP1 667..716 CDD:214559 22/48 (46%)
TSP1 779..835 CDD:214559 6/23 (26%)
PLAC 847..877 CDD:285849
ADAMTS3NP_055058.2 Pep_M12B_propep 66..200 CDD:279848
ZnMc_ADAMTS_like 256..457 CDD:239801
Reprolysin 258..460 CDD:279729
TSP1 554..605 CDD:214559 22/57 (39%)
Spacer 713..844 34/147 (23%)
ADAM_spacer1 713..827 CDD:283607 32/130 (25%)
TSP1 848..904 CDD:214559 18/57 (32%)
TSP1 912..967 CDD:214559 18/55 (33%)
TSP1 970..1015 CDD:214559 23/50 (46%)
PLAC 1023..1051 CDD:285849 3/27 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1205
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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