DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and ADAMTS4

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001307265.1	Gene:	ADAMTS4 / 9507	HGNCID:	220	Length:	846	Species:	Homo sapiens

Alignment Length:	193	Identity:	58/193 - (30%)
Similarity:	74/193 - (38%)	Gaps:	48/193 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKC---INRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSP- 242
            |..|..|..|||:|||||::..|.|   :.||       ....|.|...|::.||...|...|.
Human   523 WGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRN-------GGKYCEGRRTRFRSCNTEDCPTGSAL 580

  Fly   243 DFRASQCSAYND-----KEFHGHRYRWEPY---VKDDAECELNCMPFGMKSFATLNESVIDGTPC 299
            .||..||:|||.     |.|.| ...|.|.   |....:|:|.|....:..:..|...|:|||||
Human   581 TFREEQCAAYNHRTDLFKSFPG-PMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPC 644

  Fly   300 GHPAEYFRSQFWERAVCVDGAC----------------KAVQASGEIDGLYAHSGS---VSCG 343
            ...:.         :|||.|.|                |.:...|:..|....|||   ..||
Human   645 SPDSS---------SVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRCG 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	20/58 (34%)
		ADAM_spacer1	348..468	CDD:283607
		TSP1	667..716	CDD:214559
		TSP1	779..835	CDD:214559
		PLAC	847..877	CDD:285849
ADAMTS4	NP_001307265.1	Pep_M12B_propep	70..181	CDD:279848
		Cysteine switch. /evidence=ECO:0000250	192..199
		Reprolysin	218..428	CDD:279729
		ZnMc_ADAMTS_like	218..425	CDD:239801
		ADAM_CR	438..509	CDD:301627
		ADAM_CR	490..659	CDD:301627	50/152 (33%)
		TSP1	531..575	CDD:214559	17/50 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910