DRSC/TRiP Functional Genomics Resources

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Protein Alignment loh and ADAMTS12

DIOPT Version :9

Sequence 1:NP_609406.2 Gene:loh / 34435 FlyBaseID:FBgn0032252 Length:880 Species:Drosophila melanogaster
Sequence 2:XP_016865394.1 Gene:ADAMTS12 / 81792 HGNCID:14605 Length:1631 Species:Homo sapiens


Alignment Length:1138 Identity:225/1138 - (19%)
Similarity:335/1138 - (29%) Gaps:517/1138 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |.:||.||.|||:||.||:...|.|.|    ...:.....|.|..|||:|||..||..::|.||.
Human   545 WGRWSPWSHCSRTCGAGVQSAERLCNN----PEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQ 605

  Fly   247 SQCSAYNDKEFHGHRYRWEPYVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFW 311
            .|||.::...:....|.|.|.......|||.|.|...:....:.::|||||||.....       
Human   606 MQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGN------- 663

  Fly   312 ERAVCVDGACKAVQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLPEHAYIHVTTLP 371
            .|.||::|.||.|....|||   :::....||     |..|:.|..:|.:.  ....|:.:..:|
Human   664 SRNVCINGICKMVGCDYEID---SNATEDRCGVCLGDGSSCQTVRKMFKQK--EGSGYVDIGLIP 723

  Fly   372 VGASNISITELKNSINLLVLRTSN-ELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTE 435
            .||.:|.:.|::.:.|.|.:|:.: |....||...:..:|:|:..|.||.|       |..|..|
Human   724 KGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQY-------DRKGDLE 781

  Fly   436 WITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSS 500
            .:.:.||..:|:.:.:..: ..|.|:||||.:              ..|||             .
Human   782 KLMATGPTNESVWIQLLFQ-VTNPGIKYEYTI--------------QKDGL-------------D 818

  Fly   501 RAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKN---------------------------P 538
            ....::::.|:...::.|:.:||.|.:.....||:|.                           |
Human   819 NDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACP 883

  Fly   539 LRYYS---------------QRR-------------------CTHSVKPVLNENLLHCNTQ-PCP 568
            .|:::               ::|                   |.|.:||   :.||.||.. .||
Human   884 PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKP---KTLLSCNRDILCP 945

  Fly   569 AYWRFDDWGE-------------------------------------CRCSSSGGLRRREVSCV- 595
            :.|...:|.|                                     |..|..||:|.|.|:|. 
Human   946 SDWTVGNWSELHWLGPNTVRHSFSCTFSCAHSICFSKELISQSCFTSCSVSCGGGVRIRSVTCAK 1010

  Fly   596 ---------------------QELASGLVIHVDKAACMEDQ-PPMQKQCECPKNRRRNL------ 632
                                 |..:|..|:..:|......: ||..|....|.:|.|.|      
Human  1011 NHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGP 1075

  Fly   633 ---------------------------------------SRYRLS----------------GPSE 642
                                                   |||.:|                .|||
Human  1076 ESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSE 1140

  Fly   643 SSSNSSQV--------------------------------------------------------- 650
            .:.:||..                                                         
Human  1141 ENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPED 1205

  Fly   651 ---------KRSKIDGSDA---------------------------------------------- 660
                     .:.::.|:||                                              
Human  1206 KDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTSETGT 1270

  Fly   661 ----------------------------------------------------------------- 660
                                                                             
Human  1271 PRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGF 1335

  Fly   661 ---------------TAIWLVSDWNQYCSVTCGSGVEYRTVFC----DRSKAGEQRCDPSTTPES 706
                           :|.|:|.:|:: ||.|||.|..:|.|.|    |...|..||.||:.... 
Human  1336 LLNASNYKQLTNGHGSAHWIVGNWSE-CSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCH- 1398

  Fly   707 RRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQLITEH------------------- 752
            .|||       ..|..|.||.|:.:|....:.||:.|:.|:   :|                   
Human  1399 LRPC-------AGWKVGNWSKCSRNCSGGFKIREIQCVDSR---DHRNLRPFHCQFLAGIPPPLS 1453

  Fly   753 SECTPE------------------------------------LKPQSVEKCSHEEVEYCAARWHY 781
            ..|.||                                    .:|.|...|:    |:....|..
Human  1454 MSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCN----EHLCCHWAT 1514

  Fly   782 SDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPV 846
            .:|..|:..||||.|:|:|:|:..:......::...|.:..|.|.::.||.|||    |.....:
Human  1515 GNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC----KKSADLL 1575

  Fly   847 CA-DKFSN--CQWASQAKLCSYDYYRDNCCFSC 876
            |. ||.|.  ||.....|.||....|..|||||
Human  1576 CTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lohNP_609406.2 TSP1 182..238 CDD:214559 24/55 (44%)
ADAM_spacer1 348..468 CDD:283607 32/120 (27%)
TSP1 667..716 CDD:214559 19/52 (37%)
TSP1 779..835 CDD:214559 17/55 (31%)
PLAC 847..877 CDD:285849 15/33 (45%)
ADAMTS12XP_016865394.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I12121
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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