DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and ADAMTSL3

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_011520124.1	Gene:	ADAMTSL3 / 57188	HGNCID:	14633	Length:	1718	Species:	Homo sapiens

Alignment Length:	931	Identity:	210/931 - (22%)
Similarity:	321/931 - (34%)	Gaps:	316/931 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 TSKKAKKKVYPYPRWDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLC 232
            ||:..:........||.|.|||.|||:||||..|.:|:|          ||...|.|...||:.|
Human    64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC----------LTGRNCEGQNIRYKTC 118

  Fly   233 NDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYVKDD-AECELNCMPFGMKSFATLNESVIDG 296
            ::..|...:.||||.|||||||.::.||.|.|.|...|. |.|.|.|...|......|...|:||
Human   119 SNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDG 183

  Fly   297 TPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTR 356
            |.|...:         ..:|:.|.|:||....:   |.:::...:||     |..||.|.|....
Human   184 TRCNTDS---------LDMCISGICQAVGCDRQ---LGSNAKEDNCGVCAGDGSTCRLVRGQSKS 236

  Fly   357 NPLPE----------------HAYI-----------HVTTLPVGASNISITELKNSINLLVLRTS 394
            :..||                |...           :|..:|:|:.::.|| :|...:|.:  .|
Human   237 HVSPEKTPGLPPGQGGPLPGGHLSAIYEWPILKGEENVIAVPLGSRSVRIT-VKGPAHLFI--ES 298

  Fly   395 NELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNT 459
            ..|....||::.:..|.:.......::.|  |:|     .:.....||:...........:|.::
Human   299 KTLQGSKGEHSFNSPGVFLVENTTVEFQR--GSE-----RQTFKIPGPLMADFIFKTRYTAAKDS 356

  Fly   460 GVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGG 524
            .|::.:..||..:                                     |:...|..||.:|||
Human   357 VVQFFFYQPISHQ-------------------------------------WRQTDFFPCTVTCGG 384

  Fly   525 GTQTPIIRCIRKNPLRYYSQRRCTH---SVKPVLNENLLHCNTQPCPA----------------- 569
            |.|.....|:.....|......|.:   :|||  ...|..|:..|||:
Human   385 GYQLNSAECVDIRLKRVVPDHYCHYYPENVKP--KPKLKECSMDPCPSSDGFKEIMPYDHFQPLP 447

  Fly   570 YWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACM-EDQPPMQKQC---ECPK---- 626
            .|..:.|..|..|..||::||...||:|...|.::.|::..|| ..:|.:.:.|   :|||
Human   448 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAM 512

  Fly   627 -------NRRRNLSRYR-----------LSG---------------------PSESS-------- 644
                   ...|.| |||           :.|                     |.|.|
Human   513 EWSQCTVTCGRGL-RYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPW 576

  Fly   645 -SNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFC--------DRSKAGEQRCDP 700
             ..:.:::.::|...:.|  ::...|:. ||.|||.||:.|.|.|        ..::..|:.|:.
Human   577 LKQAQELEETRIATEEPT--FIPEPWSA-CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEG 638

  Fly   701 STTPESRRPCEKPACE------------------------------------------------- 716
            ...| :.|||...||:
Human   639 PKLP-TERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQ 702

  Fly   717 --------LGD--------------------WFTGPWSSCNGDCFDLTRTREVLCIR-SQLITEH 752
                    |.|                    |..|.|..|:..|....:||:|.|:. .:.....
Human   703 TQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPP 767

  Fly   753 SECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEY----------DI 807
            .||..| ||.:::.|:..:   |...||..:|.:|::.||||||.|.|.|.:.          |.
Human   768 EECRDE-KPHALQACNQFD---CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 828

  Fly   808 KMNALRESTH--CRYTNREP-----IYRNCNV----------QAC-------AEVPKTEVTPVCA 848
            .....:.|:|  |..|:..|     .:..|:|          |.|       ..:|.:|:  :|.
Human   829 LCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEM--MCR 891

  Fly   849 D-----KFSNCQWASQAKLCS 864
            |     ...:||....:|:.|
Human   892 DLPGLPLVRSCQMPECSKIKS 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	23/55 (42%)
		ADAM_spacer1	348..468	CDD:283607	25/146 (17%)
		TSP1	667..716	CDD:214559	18/56 (32%)
		TSP1	779..835	CDD:214559	22/82 (27%)
		PLAC	847..877	CDD:285849	6/23 (26%)
ADAMTSL3	XP_011520124.1	TSP1	78..124	CDD:214559	23/55 (42%)
		TSP1	453..>473	CDD:214559	7/19 (37%)
		TSP1	513..>542	CDD:214559	5/29 (17%)
		TSP1	598..>618	CDD:214559	10/20 (50%)
		TSP1	734..787	CDD:214559	15/56 (27%)
		TSP1	790..847	CDD:214559	18/56 (32%)
		TSP1	853..908	CDD:214559	10/56 (18%)
		Ig	956..1020	CDD:299845
		Ig	1238..1302	CDD:143165
		IG_like	1336..1410	CDD:214653
		IGc2	1341..1401	CDD:197706
		TSP_1	1516..1571	CDD:301595
		PLAC	1686..1716	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910