DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and adamts6

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_017213499.1	Gene:	adamts6 / 569099	ZFINID:	ZDB-GENE-091113-9	Length:	1116	Species:	Danio rerio

Alignment Length:	721	Identity:	184/721 - (25%)
Similarity:	286/721 - (39%)	Gaps:	189/721 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNA---CVGYFKRYQLCNDVPCDEQSPD 243
            |..|:.|..|||:|||||...:|.|       ::...|..   |:|..|||:.||...|.|.|.|
Zfish   560 WGPWTVWGECSRTCGGGVSSSMRHC-------DSPAPSGGGKYCLGERKRYRSCNTDACPEGSRD 617

  Fly   244 FRASQCSAYNDKEFHGHRYRWEPYVKDDAE-CELNCMPFGMKSFATLNESVIDGTPC-GHPAEYF 306
            ||..||:.::...|.|..|.|:||.....: |.|||:..|...:...:.:|||||.| |...:
Zfish   618 FREKQCADFDSLPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERSPAVIDGTRCQGDSLD-- 680

  Fly   307 RSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG--GLLCRPVTGIFTRNPLPEHAYIHVTT 369
                    :|::|.||.|.....:...........||  |..|....|:| .:.||...|:.|..
Zfish   681 --------ICINGECKHVGCDNILGSDAKEDRCRVCGGDGSTCELTEGLF-NDSLPRGGYMEVVQ 736

  Fly   370 LPVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVT 434
            :|.|:.:|.|.|:..|.|.:.|::..:....||..|:.....::..|..|.|.|.....:|
Zfish   737 IPKGSVHIEIREVAVSKNYIALKSEGDDYYINGAWTIDWPRKFDIAGTAFHYKRPTDEPES---- 797

  Fly   435 EWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIV-SESEENEMSLESSDGLLRSGMEDTSSSS 498
              :.::|...::|.:||..:. .|.|::|::.:||. :.|.:||:.
Zfish   798 --LEALGATMENLVVMVLLQE-QNLGIQYKFNVPIQRTGSGDNEVG------------------- 840

  Fly   499 SSRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCN 563
                     |:|..:.:|.|:.:|.||:|...:.|.|.:.........|....||..|:.  .||
Zfish   841 ---------FSWHHLPWSECSATCAGGSQKQEVVCKRLDDNSVVQNSYCDQDSKPPGNQR--RCN 894

  Fly   564 TQPCPAYWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQC---ECP 625
            |:|||..|...||.||..:..||:|.|.|.|::::.......::.:.|:..:|..|:.|   .||
Zfish   895 TEPCPPEWFIGDWSECGKTCDGGIRTRTVLCIRKINPAEEETLEDSHCLTHRPIEQESCNNQSCP 959

  Fly   626 KNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDR 690
            ..                                    |:..||:: |:..||.|.::|.|.|..
Zfish   960 PQ------------------------------------WVTLDWSE-CTPKCGPGFKHRIVLCKS 987

  Fly   691 SKAGEQRCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSEC 755
            |                                          |||:|     ..:.|.::||
Zfish   988 S------------------------------------------DLTKT-----FPAALCSDHS-- 1003

  Fly   756 TPELKPQSVEKCSHEEVEYC-AARWHYSDWSECTKPCGGGTQRRSVRCLEYDIK-----MNALRE 814
                ||....:||   :..| ..||...:|.:|:..||.|.|.|:|:||.|..:     :::||.
Zfish  1004 ----KPPVRIRCS---LGRCPPPRWIPGEWGQCSAQCGLGQQMRTVQCLSYTGQPSSECLDSLRP 1061

  Fly   815 STHCRYTNREPIYRNCNVQACAEVPKTEVTPV-----CAD--KFSNCQWASQAKLCSYDYYRDNC 872
            :|               :|.|..  |.:.||:     |.|  |.:.|....:.|.||..|:|..|
Zfish  1062 NT---------------MQQCES--KCDSTPISGGDECKDVNKVAYCPLVLKFKFCSRAYFRQMC 1109

  Fly   873 CFSCTG 878
            |.:|.|
Zfish  1110 CKTCQG 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	21/58 (36%)
		ADAM_spacer1	348..468	CDD:283607	29/119 (24%)
		TSP1	667..716	CDD:214559	10/48 (21%)
		TSP1	779..835	CDD:214559	16/60 (27%)
		PLAC	847..877	CDD:285849	11/31 (35%)
adamts6	XP_017213499.1	Pep_M12B_propep	40..187	CDD:307618
		ZnMc_ADAMTS_like	249..464	CDD:239801
		TSP1	560..612	CDD:214559	21/58 (36%)
		ADAM_spacer1	719..828	CDD:310520	29/116 (25%)
		TSP1	847..899	CDD:214559	16/53 (30%)
		TSP1	901..959	CDD:214559	15/57 (26%)
		TSP1	1021..1068	CDD:214559	16/61 (26%)
		PLAC	1082..1114	CDD:312271	11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910