DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and LOC568792

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_001922446.3	Gene:	LOC568792 / 568792	-ID:	-	Length:	1224	Species:	Danio rerio

Alignment Length:	726	Identity:	206/726 - (28%)
Similarity:	291/726 - (40%)	Gaps:	143/726 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 RWDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFR 245
            :|..||.||||||||..||.::.|.|.:.......:.    |.|..:.|:|||...|...:.|||
Zfish   607 QWSSWSGWSSCSRSCESGVTHRERVCSSPRPAHGGRF----CEGSSRSYKLCNTDDCPANTVDFR 667

  Fly   246 ASQCSAYNDKEFHGHRYRWEPYVK-DDAE-CELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRS 308
            |:||:.:|.|.|.|..|:|.||.: ||.: |:|.|:..|...|..|:..|.|||.|...:
Zfish   668 AAQCAEFNSKPFRGWYYKWRPYTRVDDQDVCKLYCLAEGYDFFFALSSKVRDGTLCAQDS----- 727

  Fly   309 QFWERAVCVDGACKAVQASGEIDGLYAHSGSV--SCG-----GLLCRPVTGIFTRNPLPEH---A 363
                ..||:||.|:.|.....:.     |.:|  .||     ...|:...|.:::    :|   .
Zfish   728 ----TDVCIDGICEKVGCDRVLG-----SNAVPDMCGVCKGDNSTCKIYKGQYSK----QHHLSQ 779

  Fly   364 YIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAE 428
            |..|.|:|.||.:|.::||.:|.:.|.||........||..||...|.:...||:|||.|.....
Zfish   780 YYRVVTIPAGARSIRVSELNSSSSYLALRNLQRKYYLNGAWTVDWPGRHSIAGAIFDYKRPYNRP 844

  Fly   429 DSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMED 493
            :|      ::|.||...:|.:.|..:.. |.||::||.|
Zfish   845 ES------LSSSGPTNQTLVIEVLLQGW-NPGVQWEYTL-------------------------- 876

  Fly   494 TSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRY-YSQRRCTHSVKPVLNE 557
                   ...:|..::|.|:. |.|:.||.||.......|.|  .||: .:...|:...:|  :.
Zfish   877 -------NREQKHNYSWAVVR-SQCSSSCAGGQMVSKSICYR--DLRFQVNSSYCSARSRP--SS 929

  Fly   558 NLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQC 622
            .::.||||||||.|...||..|..|...|.:.|.|.|||:.....:..|..|.|.:..|.....|
Zfish   930 GVMSCNTQPCPASWSVQDWSSCSRSCGSGQQVRRVVCVQKTGPDQLETVADAQCPQPAPAHTHSC 994

  Fly   623 ---ECPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYR 684
               .||              |:                      |....|.| ||..||.||..|
Zfish   995 NTHSCP--------------PA----------------------WSAGAWTQ-CSRKCGKGVMKR 1022

  Fly   685 TVFCDRSKA---GEQRCDPSTTPESRRPCEKPAC---ELGDWFTGPWSSCNGDCFDLTRTREVLC 743
            .|.|..|..   .:..|.....|..:..|....|   ....||...|:.|:..|.:..:.|.|.|
Zfish  1023 PVLCVLSNGVVLPDSSCADLLKPSVQEICFIKHCRKQRKAQWFVSTWTPCSVSCGEGLQQRVVKC 1087

  Fly   744 IRSQLITEHSECTPELKPQSVEK--------CSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSV 800
            .......::.|.: :.|.|.|.:        |...|.......|:.|.||:||..||||.|.|||
Zfish  1088 AEKDYSGKYRELS-QKKCQHVSRPSVDLQRVCVQAECPAAGTHWYSSPWSQCTVSCGGGVQIRSV 1151

  Fly   801 RCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFSNCQWASQAKLCSY 865
            :||...      |.::.|....:..:.:.||...|.:....:|  ||.|.||.|....|..:|::
Zfish  1152 QCLSLG------RPASGCVLQMKPLMSQACNTAFCPQPELNDV--VCKDHFSWCYLVPQHSVCNH 1208

  Fly   866 DYYRDNCCFSC 876
            .:|...||.||
Zfish  1209 KFYGKQCCKSC 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	21/55 (38%)
		ADAM_spacer1	348..468	CDD:283607	37/122 (30%)
		TSP1	667..716	CDD:214559	16/54 (30%)
		TSP1	779..835	CDD:214559	20/55 (36%)
		PLAC	847..877	CDD:285849	12/30 (40%)
LOC568792	XP_001922446.3	Pep_M12B_propep	86..203	CDD:279848
		ZnMc_ADAMTS_like	309..510	CDD:239801
		Reprolysin	311..514	CDD:279729
		TSP1	617..660	CDD:214559	15/46 (33%)
		ADAM_spacer1	765..876	CDD:283607	37/121 (31%)
		TSP1	1067..1124	CDD:214559	12/57 (21%)
		TSP1	1133..1181	CDD:214559	19/53 (36%)
		PLAC	1190..1220	CDD:285849	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910