DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and si:ch211-267e7.3

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_696251.5	Gene:	si:ch211-267e7.3 / 567853	ZFINID:	ZDB-GENE-070912-265	Length:	963	Species:	Danio rerio

Alignment Length:	983	Identity:	227/983 - (23%)
Similarity:	327/983 - (33%)	Gaps:	365/983 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |.:||.||:|||:|||||:.|.|.|:.:.|.:...:.|:.|:|..|:||||.:.||......|:.
Zfish    53 WGEWSSWSTCSRTCGGGVRSQERHCLQQRLTSTQNINSSFCIGPSKQYQLCTNQPCPNSRISFKQ 117

  Fly   247 SQCSAYNDKEFHGHRYRWEPYVKDD------AECELNCMPFGMKSFATLNESVI-----DGTPCG 300
            .|||.:|.|.|....|.|.|...||      ..|:|.|.       .|..|..:     |||.|
Zfish   118 HQCSQFNAKAFSRKHYEWVPLYPDDYINISNKPCDLQCT-------TTTGERQLLVPAHDGTFC- 174

  Fly   301 HPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLP 360
                  |...:: .||::|.|:.|...|:   ||:......||     |..|..|:|.: |..:.
Zfish   175 ------RDGIYQ-GVCIEGQCQVVGCDGK---LYSSKTIDKCGVCGGNGASCYRVSGTY-RKGIT 228

  Fly   361 EHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHR-- 423
            :..|:.:|.:||||::|.|.|.:.:.|:|.|........|||.:.:....::...|.||.|.|
Zfish   229 QLGYVFITNIPVGATDIQIIERRKTENILALSDEAGHFFFNGNSVIDNPQNFHVAGTVFKYRRPA 293

  Fly   424 ---IDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLP----------------- 468
               .||       .|:|.:.||.:.:|.:|.:..:.....:.|||.:|
Zfish   294 NLFSDG-------FEYIMAQGPTQQALNVMYYNLNGKMPHITYEYTVPRAPAFPMTSTPEQPQIS 351

  Fly   469 -----------------IVSESEENEM--------------SLESSDG----------------- 485
                             ..|.:|.||:              ||...|.
Zfish   352 NLMSKTSRDSSVAEPKGNTSSTEHNEIGARKQHEKKSNQSSSLVPQDNVDVHEELLWGLQASVNF 416

  Fly   486 -------LLRSGME----------------------------DTSSSSSSRA------------- 502
                   |.|...|                            |:||||.|..
Zfish   417 SELPALVLFRPASEVLQNELDDEIHHLEAQENFGPDSNLIDGDSSSSSDSNTSIPLLKSLLYDGA 481

  Fly   503 -----------------------------------------------GRKR-------------- 506
                                                           |..|
Zfish   482 SWSSRQPCKDSSALSGCSILKLNSSAPLDNSLTLEIYPGSLDLHSPDGEPRTNDSTNHQSNILQL 546

  Fly   507 -----------------------------IFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYY 542
                                         ::.|||..::.|:.:|..|..|....|::.:... .
Zfish   547 HQMEPVQAPHSESNEFEVESLDHDVSMSDMYRWKVSAYAPCSSTCTTGISTSYALCVKYDGTE-V 610

  Fly   543 SQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVD 607
            .:..|....:|......  |..:.|...|....|.||..:...|.:.|.|.|.:.:|.|....|.
Zfish   611 DESYCDALTRPEPTHEF--CTGKECLPRWETSRWSECSRTCGEGFQFRTVRCWKMMAPGFDSSVY 673

  Fly   608 KAAC--MEDQPPM-QKQCECPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDW 669
            ...|  :|.|.|| :|.|           :.:..||.                      |.:|||
Zfish   674 DELCQAVELQKPMTRKAC-----------KSKSCGPQ----------------------WEISDW 705

  Fly   670 NQYCSVTCGS-GVEYRTVFCDRSKAGEQR-CDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDC 732
            :: ||..||. ||..|.|.|..    |.| |:.||.|.|:|.||.|.|: ..|....|..|:|.|
Zfish   706 SE-CSARCGGRGVRSRDVRCSM----EARLCNESTKPVSQRECEGPPCD-RRWTVSDWGPCSGPC 764

  Fly   733 FDLTRTREVLCIRSQ-LITEHSECTPELKPQSVEKCS---------HEEVEYC------------ 775
            .:....|.|:|..|. .:....:|.|||||.:|..|.         .:|.|.|
Zfish   765 GEGRMKRYVVCKNSNGKVISDGQCDPELKPLAVHPCGDKNCPAHWVEQEWEQCNSTCGRGVKTRQ 829

  Fly   776 -----------------------------------AARWHYSDWSECTKPCGGGTQRRSVRCLEY 805
                                               .::|..:.||:|:|.||.|.:.|.|:|.:.
Zfish   830 VVCAGLEAGVFKEFPERMCDRALRPADTAACFERPCSKWFTTSWSQCSKTCGIGVRVREVKCYQG 894

  Fly   806 DIKMNALRESTH-CRYTNREPIYRNCNVQACAEVPKTEVTPVCADK-FSNCQWASQAKLCSYDYY 868
            :       |..| |..|.|....::|.||.|...|..:  ..|.|| .:||....:.|||::.||
Zfish   895 E-------ELGHSCDTTLRPEARQSCEVQPCTTEPPAD--DACQDKPTANCALVLRVKLCTHWYY 950

  Fly   869 RDNCCFSC 876
            |..||.||
Zfish   951 RKACCLSC 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	26/55 (47%)
		ADAM_spacer1	348..468	CDD:283607	34/124 (27%)
		TSP1	667..716	CDD:214559	23/50 (46%)
		TSP1	779..835	CDD:214559	19/56 (34%)
		PLAC	847..877	CDD:285849	15/31 (48%)
si:ch211-267e7.3	XP_696251.5	TSP1	53..109	CDD:214559	26/55 (47%)
		ADAM_spacer1	217..334	CDD:283607	34/124 (27%)
		TSP1	637..>660	CDD:214559	7/22 (32%)
		TSP1	700..749	CDD:214559	24/53 (45%)
		TSP1	752..806	CDD:214559	17/53 (32%)
		TSP1	865..918	CDD:214559	19/59 (32%)
		PLAC	928..959	CDD:285849	15/31 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9522
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910