DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and adamts10

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001116746.1	Gene:	adamts10 / 564734	ZFINID:	ZDB-GENE-081104-414	Length:	1108	Species:	Danio rerio

Alignment Length:	755	Identity:	194/755 - (25%)
Similarity:	282/755 - (37%)	Gaps:	182/755 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 KVEEVFSSPNPPQEAT---SSTSKKA---KKKVYPY---PR-----WDKWSDWSSCSRSCGGGVK 200
            |.....:|..|..|.|   :||.:|.   |:...||   |.     |..||.|..|||:|||||.
Zfish   509 KGNRCITSSIPAAEGTICQTSTIEKGWCYKRLCVPYGTRPEGVDGGWGHWSPWEECSRTCGGGVS 573

  Fly   201 YQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWE 265
            ..:|.|.:.......:.    |:|..||::.||...|...|.|||..|||.::...|.|..|.|:
Zfish   574 SSIRHCDSPRPTVGGKY----CLGERKRFRSCNIDECPVGSQDFREIQCSDFDSVPFRGKFYTWK 634

  Fly   266 PY----VKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQA 326
            ||    ||   .|.|||:..|...:.....:|:|||||       |....:  |||:|.||.|..
Zfish   635 PYRGGGVK---SCSLNCLAEGYNFYTERAPAVVDGTPC-------RDDSLD--VCVNGECKHVGC 687

  Fly   327 SGEIDGLYAHSGSVSCG--GLLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITELKNSINLL 389
            ...:...........||  |..|:.:.|:| .:.|.|..|..|..:|.|:..|.|.||..|:|.|
Zfish   688 DRILGSDVREDRCRVCGGDGSSCQVIEGVF-NDSLSEGGYEEVVRIPKGSVFIHIQELNISLNYL 751

  Fly   390 VLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTK 454
            ||::..:....||:.|:.....::..|..|.|.|      .....|.:.::||...:|.:||..:
Zfish   752 VLKSKGDQYFINGKLTIDTPRRFDIAGGTFHYRR------PANEPETLEALGPTNMTLIVMVLVR 810

  Fly   455 SANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFNWKVIGFSSCT 519
            . .|.|:.|.:..|:                     ..|..||          ::|....:|.|:
Zfish   811 E-ENPGILYRFNPPV---------------------SRDPLSS----------YSWHYTSWSRCS 843

  Fly   520 KSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSS 584
            ..|.||.|...:.|.::..|.......|....||  .:....||.:|||..|...||.||..|.:
Zfish   844 ALCAGGVQVQQVVCKKQADLSVVYNHFCDKKNKP--KDKKRPCNQEPCPPTWWTGDWSECSRSCN 906

  Fly   585 GGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCE---CPKNRRRNLSRYRLSGPSESSSN 646
            ||:|.|||.|.::::......:|..||...:|.:.:.|.   ||..
Zfish   907 GGVRTREVLCKRKMSVTEEKVLDDTACTTTRPSVTEPCNNHTCPPE------------------- 952

  Fly   647 SSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQRCDPSTTPESRRPCE 711
                             |...||:: |:..||.|..||.:.|.....||      |.||
Zfish   953 -----------------WHALDWSE-CTPGCGPGYRYRVILCRSGDNGE------TLPE------ 987

  Fly   712 KPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSECTPELKPQSVEKCSHEEVEYC- 775
                                                     |||..:.:|.:..:|:   ::.|
Zfish   988 -----------------------------------------SECPKQSRPTTRVRCN---IQRCP 1008

  Fly   776 AARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPK 840
            ..:|....|.||:..||.|.:.|.|:||.:     ..:.|..|..::|....:.|. ..|.....
Zfish  1009 PPQWVAGPWGECSARCGMGQEIRFVQCLTH-----TGQPSNECPESHRPAFMQQCK-SKCDHSGP 1067

  Fly   841 TEVTPVCAD--KFSNCQWASQAKLCSYDYYRDNCCFSCTG 878
            |:....|.|  ..:.|....:.|.|...|:|..||.:|.|
Zfish  1068 TDNPEECKDVNTVAYCPLVLRFKFCGRAYFRQMCCKTCQG 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	20/55 (36%)
		ADAM_spacer1	348..468	CDD:283607	33/119 (28%)
		TSP1	667..716	CDD:214559	14/48 (29%)
		TSP1	779..835	CDD:214559	15/55 (27%)
		PLAC	847..877	CDD:285849	9/31 (29%)
adamts10	NP_001116746.1	Pep_M12B_propep	71..189	CDD:279848
		Reprolysin	244..462	CDD:279729
		ZnMc_ADAMTS_like	244..459	CDD:239801
		TSP1	555..607	CDD:214559	20/55 (36%)
		ADAM_spacer1	711..823	CDD:283607	33/119 (28%)
		TSP1	893..950	CDD:214559	18/56 (32%)
		PLAC	1074..1106	CDD:285849	9/31 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910