DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and thsd7aa

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_009292626.1	Gene:	thsd7aa / 557991	ZFINID:	ZDB-GENE-060503-709	Length:	1702	Species:	Danio rerio

Alignment Length:	1214	Identity:	235/1214 - (19%)
Similarity:	364/1214 - (29%)	Gaps:	528/1214 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QADLTTKERIKKHQDWLREHRKPKTKKKISINSYYELANLWHTRKDLSSPKQKPNNKEEYLENET 88
            :|:...|...:..|:...:.||.|.||::..:....:......:|.:..|:.:     |.::.:.
Zfish   270 KAERKAKRDRQARQERQGKRRKNKEKKELRESKGERVRERVKEKKRMRDPETR-----ELIKKKR 329

  Fly    89 TSKISNKS-----DEKVLKSSTIISLNATNPSTSTFKSVLETTTLP------------------- 129
            |....|:.     |.:|...:..::....:.||::.....: .|||
Zfish   330 TRNRQNRQGLKFWDLQVGYQTREVTCVHRSGSTASISQCTQ-QTLPVTYQACVISKDCEVSEWSD 393

  Fly   130 -SVTTKDLFE----SGNVATTRQT-----------PKVEEVFSSPNPPQ-EATSSTSKKAKKKVY 177
             ||.:|:.::    .|....|||.           |::||  |.|..|| |.....      .||
Zfish   394 WSVCSKECYDLNGRKGQRTRTRQVQQFPVGGGAECPELEE--SEPCSPQGEGIPPC------VVY 450

  Fly   178 PYPRWDKWSDWSSC-----------SRS-----CGGGVKYQVRKCINRNLLTNNQL--------- 217
               .| :.::||.|           .||     |||||:.:...|:.....|::.|
Zfish   451 ---NW-RSTEWSDCRVDVLLSQQDRRRSNQTGLCGGGVQTREVYCVQAPSETSSNLGSLKSKDAL 511

  Fly   218 ---TSNACVGY-FKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYVKDDAECELNC 278
               .|:.|:|. ....|||: :||..:      .:.||::         .|.|...::.:.:...
Zfish   512 RPVNSDLCLGVPHNTTQLCH-IPCPVE------CEVSAWS---------AWGPCTFENCQDQSTK 560

  Fly   279 MPFGMKSFATLNE---------SVIDGTPCGHPAEYFRSQFW---ERAVCV---DGAC------- 321
            ..|.::....:||         .:.:..||..|:.|    .|   :...||   |..|
Zfish   561 KGFKLRKRKIMNEPTGGTGNCPHLTEAIPCEEPSCY----DWLLVKLEECVPDNDKVCGPGTQNP 621

  Fly   322 --KAVQASGE-IDGLYAHSGSVSCGGLLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITEL- 382
              :.:.:.|| :|            ..|||..                :..:||      :.|:
Zfish   622 QVQCINSDGEFVD------------RQLCRDA----------------ILPMPV------LCEVS 652

  Fly   383 --KNSINLLVLRTSNELAIFNGENTVS---ESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGP 442
              |:.:  |...||..|.    .||.|   ..|......::..|:..||....           |
Zfish   653 CPKDCV--LSPWTSWSLC----SNTCSGKNSEGKQTRARSILAYNAGDGGVQC-----------P 700

  Fly   443 IRDSLQLMVFTKSAN-NTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTS----SSSSSRA 502
            ...:||.:   :|.| :....|.:                 ..|.....:||||    :||.|||
Zfish   701 NSSALQEV---RSCNDHPCTVYHW-----------------QTGPWGQCIEDTSVPSANSSISRA 745

  Fly   503 GRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKP-VLNENLLHCN--- 563
                     |.|.:.....|..|.||..:.|:|.| :.....::|..|::| .:...||.|.
Zfish   746 ---------VPGTAVNDAFCSVGMQTRKVICVRVN-VGQVPPKKCPESLRPETVRPCLLPCKRDC 800

  Fly   564 ------------------------------------------------------TQPCPAY-WRF 573
                                                                  :..||.| |:.
Zfish   801 VVTPYSDWTPCPSICQTGGSVKKKQSRKRIIIQLPANGGQDCPEVLFQEKDCDASSVCPGYRWKT 865

  Fly   574 DDWGEC-------RCSSSG-------GLRRREVSCVQELASGLVIHVDKAACME---DQPPMQKQ 621
            ..|..|       |..|.|       ||:.|.||| ::|.||   ..|.|||::   ..|.:.:.
Zfish   866 HKWRRCQLVPWSIRQDSPGAQETCGPGLQARAVSC-KKLDSG---PADVAACLKFAGPMPQLTQS 926

  Fly   622 CECP-----------------------KNRRRNL--------------------------SRY-- 635
            |:.|                       :.|:|.|                          ::|
Zfish   927 CQLPCQDDCQLTAWSKFSTCAADCVGVRTRKRTLVGKSKKREQCKNTQMYPLSETQYCPCNKYNA 991

  Fly   636 --------------RLSG----------------------------------------------- 639
                          |:.|
Zfish   992 QPVGNWSDCILPEGRVEGLLGMKVQGDIKECGQGYRYQAMVCYDQDNRLVETSRCNSHGYIEEAC 1056

  Fly   640 ----PSESS----SNSSQVKRSKIDGSDATAIWL----------------------------VSD 668
                ||:..    ||.|:..:|...|....:.||                            :||
Zfish  1057 IIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCLSD 1121

  Fly   669 WNQYCSV----------------TCGSGVEYRTVFCDRSKAG-------EQRCDPSTTP----ES 706
            .:||..|                .||.||:.|.|.|.::...       :..|||...|    ||
Zfish  1122 CSQYVWVAEPWSVWKVSNVDLKENCGEGVQTRKVRCMQNTVDGPSDPVEDYLCDPEEMPLGARES 1186

  Fly   707 RRPCEKPACELGDWFTGPWSSCNGDC-FDLTRTREVLCIRSQLITEHSECTPELKPQSVEKCSHE 770
            :.||.:. |.|.||  |.||.|...| .:.||.|....||..  :|..:|     |.:.||
Zfish  1187 KLPCPED-CVLTDW--GSWSRCPLPCNVNSTRQRSASPIRQP--SERKQC-----PSTTEK---- 1237

  Fly   771 EVEYCAAR---WHYS----DWSEC----TKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNRE 824
              |.|...   :|||    |||.|    ...||.|.:.|.:.|:..|.|...|:   .|.....|
Zfish  1238 --EICTLNSNCFHYSYNITDWSTCQLSERAVCGVGFKTRMLDCVRSDSKSVDLK---FCEELGLE 1297

  Fly   825 PIYRNCNVQACAEVPKTEVTPVCADKFSNCQ---WASQAKLCSY 865
            ..:: .|.....|.|            .|||   |:|.:: ||:
Zfish  1298 KKWQ-MNASCVVECP------------VNCQLSDWSSWSE-CSH 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	21/84 (25%)
		ADAM_spacer1	348..468	CDD:283607	22/126 (17%)
		TSP1	667..716	CDD:214559	20/75 (27%)
		TSP1	779..835	CDD:214559	18/63 (29%)
		PLAC	847..877	CDD:285849	7/22 (32%)
thsd7aa	XP_009292626.1	TSP1	186..236	CDD:214559
		TSP1	388..440	CDD:214559	12/53 (23%)
		TSP1	660..716	CDD:214559	15/73 (21%)
		TSP1	1067..>1105	CDD:214559	7/37 (19%)
		TSP1	1317..1367	CDD:214559	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910