DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and Adamts18

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_038953789.1	Gene:	Adamts18 / 361412	RGDID:	1560118	Length:	1253	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	220/740 - (29%)
Similarity:	311/740 - (42%)	Gaps:	149/740 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 PYP---RWDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDE 239
            |.|   :|..||.||.|||:||||||||.|.|.|    ...|.....|.|..:.|:|||..||.|
  Rat   620 PRPIHGQWSAWSKWSECSRTCGGGVKYQERHCSN----PKPQYGGKYCPGSSRIYKLCNINPCHE 680

  Fly   240 QSPDFRASQCSAYNDKEFHGHRYRWEPYVKDDAE--CELNCMPFGMKSFATLNESVIDGTPCG-H 301
            .|.||||.||:.||:|.|.|..|||.||.|.:.|  |:|.|.....:.|..::..|.|||||. |
  Rat   681 NSLDFRAQQCAEYNNKPFRGWLYRWRPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPH 745

  Fly   302 PAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLPE 361
                      ...||:||.|:.|....|   |.:.:.|.:||     ...|:...|::    |.:
  Rat   746 ----------RNDVCIDGICEPVGCDHE---LGSKAVSDACGVCKGDNSTCKFYKGLY----LSQ 793

  Fly   362 H---AYIHVTTLPVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHR 423
            |   .|..|.|:|.||.:|.|.||:.|.:.|.:|:.::.....|...:...|.:...|..|:|.|
  Rat   794 HKANEYYPVVTIPAGARSIEIQELELSSSYLAVRSLSQKYYLTGGWNIDWPGDFTFAGTTFEYQR 858

  Fly   424 IDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLR 488
                  .....|.:.:.||..::|...:.|: ..|.|:.::|.||.|
  Rat   859 ------PFNRPERLYAPGPTNETLVFEILTQ-GKNPGITWKYALPKV------------------ 898

  Fly   489 SGMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKP 553
                   .:.:..|.::....|:.:. |.|:.:||||..:....|:|....:..|. .|:...||
  Rat   899 -------MNVTQPAAKRHHHTWRTVQ-SDCSVTCGGGYISIKAICLRDQNTQVNSS-FCSVRTKP 954

  Fly   554 VLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVSCVQE---LASGLVIHVDKAACMEDQ 615
            .....|  ||...|||||...:|..|..|.:||.:.|::.|||:   .....|:|   :.|....
  Rat   955 ATEPKL--CNAFSCPAYWLPGEWSTCSKSCAGGQQSRKIRCVQKKPFQKEEAVLH---SLCPVST 1014

  Fly   616 PPMQKQCE---CPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTC 677
            |...:.|.   ||..                                    |....|:| ||.||
  Rat  1015 PTQVQVCNSHACPPE------------------------------------WSPGPWSQ-CSKTC 1042

  Fly   678 GSGVEYRTVFCDRSKA---GEQRCDPSTTPESRRPCEKPACELGD---WFTGPWSSCNGDCFDLT 736
            |.||..|.|.|....|   .|..|..|..||::..|....|...:   |....|:.|:..|....
  Rat  1043 GRGVRRREVLCTSPAAETLPESLCSSSPKPEAQEGCVLGRCPKNNRLQWIASAWTECSATCGLGV 1107

  Fly   737 RTREVLC----IRSQLITEHSECTPELKPQSVEKCSHEEVEYC----------AARWHYSDWSEC 787
            |.||..|    ::.:|:|     .||.:.::::|.:.|..|.|          ||.|:.|.|.:|
  Rat  1108 RKREFKCMEKTLQGKLMT-----FPERRCRNIKKPNLELEETCNRRACPVYSMAAGWYSSPWQQC 1167

  Fly   788 TKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFS 852
            |..||||.|.|||.|::..      |.|:.|....:.|:.|.||...| .||:....|.|.|.||
  Rat  1168 TVTCGGGVQTRSVHCMQQG------RPSSSCLLHQKPPVLRACNTNFC-PVPEKRDDPSCVDFFS 1225

  Fly   853 NCQWASQAKLCSYDYYRDNCCFSCT 877
            .|:...|..:|::.:|...||.||:
  Rat  1226 WCRLVPQHGVCNHKFYGKQCCRSCS 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	27/55 (49%)
		ADAM_spacer1	348..468	CDD:283607	30/122 (25%)
		TSP1	667..716	CDD:214559	19/51 (37%)
		TSP1	779..835	CDD:214559	21/55 (38%)
		PLAC	847..877	CDD:285849	11/29 (38%)
Adamts18	XP_038953789.1	Pep_M12B_propep	99..238	CDD:396235
		ZnMc_ADAMTS_like	328..529	CDD:239801
		ADAM_CR_2	546..613	CDD:407643
		TSP1	627..679	CDD:214559	27/55 (49%)
		ADAM_spacer1	784..896	CDD:368694	30/122 (25%)
		TSP1_ADAMTS	918..966	CDD:408800	15/50 (30%)
		TSP1_ADAMTS	970..1026	CDD:408800	15/58 (26%)
		TSP1_ADAMTS	1030..1083	CDD:408800	20/53 (38%)
		TSP1_ADAMTS	1091..1150	CDD:408800	16/63 (25%)
		TSP1_ADAMTS	1159..1205	CDD:408800	19/51 (37%)
		PLAC	1220..1250	CDD:400844	11/29 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910