DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and ADAMTSL5

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_011526263.1	Gene:	ADAMTSL5 / 339366	HGNCID:	27912	Length:	485	Species:	Homo sapiens

Alignment Length:	298	Identity:	91/298 - (30%)
Similarity:	131/298 - (43%)	Gaps:	41/298 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |..|..|:.||.|||.||..:.|:|:.   |...:    .|.|....|:||....|...:..||.
Human    48 WTPWVSWTRCSSSCGRGVSVRSRRCLR---LPGEE----PCWGDSHEYRLCQLPDCPPGAVPFRD 105

  Fly   247 SQCSAYNDKEFHGHR--YRWEPYVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQ 309
            .||:.||.:...|.:  |:|.|:.....:|:|||:..|...:.:... |:|||.|...|:
Human   106 LQCALYNGRPVLGTQKTYQWVPFHGAPNQCDLNCLAEGHAFYHSFGR-VLDGTACSPGAQ----- 164

  Fly   310 FWERAVCVDGACKAVQASGEIDGLYAHSGSVS-----CGGL--LCRPVTGIFTRNPLPEHAYIHV 367
                .|||.|.|    .|...|||.. ||::.     |||.  .|..|..:| |:......|.:|
Human   165 ----GVCVAGRC----LSAGCDGLLG-SGALEDRCGRCGGANDSCLFVQRVF-RDAGAFAGYWNV 219

  Fly   368 TTLPVGASNISIT-ELKNSINLL-VLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDS 430
            |.:|.||.:|.:. ..:|.:.:| .|...:...:.||...||..|:|||.|....|.|      .
Human   220 TLIPEGARHIRVEHRSRNHLGILGSLMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTR------D 278

  Fly   431 NGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLP 468
            .|..|.:.:.||....|.|.|..:.. |.|:::|:.||
Human   279 TGPQETLQAAGPTSHDLLLQVLLQEP-NPGIEFEFWLP 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	18/55 (33%)
		ADAM_spacer1	348..468	CDD:283607	34/121 (28%)
		TSP1	667..716	CDD:214559
		TSP1	779..835	CDD:214559
		PLAC	847..877	CDD:285849
ADAMTSL5	XP_011526263.1	TSP1	48..97	CDD:214559	18/55 (33%)
		ADAM_CR	<106..174	CDD:301627	24/81 (30%)
		ADAM_spacer1	206..315	CDD:283607	33/116 (28%)
		NTR_like	379..480	CDD:239600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910