Protein Alignment loh and Adamts20

DIOPT Version :9

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: XP_038936261.1
• Gene: Adamts20 / 315263
• RGDID: 1307725
• Length: 1928
• Species: Rattus norvegicus
• Alignment Length: 1039
• Identity: 240/1039 - (23%)
• Similarity: 343/1039 - (33%)
• Gaps: 303/1039 - (29%)

  Fly    18 HDSSFVQADLTTKERIKKHQDWLREHRKPKTKKKISINSYYELANLWHTRKDLSSPKQKPNNKEE 82
            ||.||...:..||.:.......|..|..|.|....|.....|..:..|....|    .|||.:..
  Rat   411 HDDSFKCKESGTKHQYHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLL----DKPNGRTY 471

  Fly    83 YLENETTSKI--SNKSDEKVLKSSTIISLNATNPSTSTFKSVLETTTLPSVTTKDLFESGNVATT 145
            .|..:....:  .||..|.:.           .|.:.....:.:...|...:.:.:.:.   ..|
  Rat   472 DLSPQLPGSVYDGNKQCELMF-----------GPGSQVCPYLKQCRRLWCTSAEGVHKG---CRT 522

  Fly   146 RQTPKVEEVFSSPNPPQEATSSTSKKAKKKVYPYP-RWDKWSDWSSCSRSCGGGVKYQVRKCIN- 208
            :..|..:.  :|..|..............:..|.. .|..|..:|||||:||||::...|.|..
  Rat   523 QHMPLADG--TSCGPGMHCHRGLCVTRDMETRPVDGEWGPWGPYSSCSRTCGGGIRSTARLCDRP 585

  Fly   209 --RNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFH----GHRYRWEP- 266
              ||       ....|||...:::.||...|.:...|||..|||.::.|.|.    ....||.|
  Rat   586 EPRN-------GGRYCVGRRMKFRSCNTDSCPKGKRDFREKQCSDFDGKHFDISGLPPNVRWLPK 643

  Fly   267 ----YVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQAS 327
                .|||  .|:|.|...|..||..|.:.|.||||||...         ..:||.|.|:.....
  Rat   644 YSGIAVKD--RCKLYCRVAGTTSFYQLKDRVADGTPCGTET---------NDICVQGLCRQAGCD 697

  Fly   328 GEIDGLYAHSGSVSCGG--LLCRPVTGIFTRNPLPEHAYIHVTTLPVGASNISITELKNSI---- 386
            ..::..........|||  ..|:.:.|:|..   ..:.|..|..:|.||:||.|  |::|.
  Rat   698 HVLNSKAKRDKCGVCGGDNSSCQTLAGVFNS---AHYGYNVVVKIPAGATNIEI--LQHSYSGRP 757

  Fly   387 ---NLLVLRTSNELAIFNGENTVS-ESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSL 447
               |.|.|..:....:.||...|| ........||||:|      ..||...|.|.|...:...|
  Rat   758 EDDNYLALSDTQGNFLLNGNFVVSMAKKEINIQGAVFEY------SGSNNSIERINSTDRLEAEL 816

  Fly   448 QLMVF-TKSANNTGVKYEYMLPIVSESEENEMS------------------------LESSDGLL 487
            .|.|. ..:..|..|.|.:.:||  |...|..|                        :..||
  Rat   817 VLQVLCVGNLYNPDVHYIFNIPI--EERSNLFSWDPYGPWQDCTKMCQGLHRRKIACIRKSD--- 876

  Fly   488 RSGMEDTSSSS-------SSRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQR 545
            |:.:.|.|.|.       :.|........|.:.|.|.|:..||.|.:|..:.|::      ||..
  Rat   877 RAVVSDQSCSHLPLPLFVTERCNTDCELRWHITGKSDCSSQCGQGYRTLDVHCMK------YSVH 935

  Fly   546 R----------CTHSVKPVLNENLLHCNTQPCP-----AYWRFDDWGECRCSSSGGLRRREVSCV 595
            :          |...:||.        |.:||.     ..|.:.:|.:|..|..||.:.||..||
  Rat   936 KGQTVPVGDQYCGDQLKPP--------NREPCHGSCVLTRWHYSEWSQCSRSCGGGEKTRESYCV 992

  Fly   596 QELASGLVIHVDKAACMEDQPPMQKQC-ECPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSD 659
            ......|.               :::| |.|:....|.:.:...|
  Rat   993 NGFGHRLA---------------ERECQELPRVVLGNCNDFPCPG-------------------- 1022

  Fly   660 ATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSK--AGEQRCDPSTTPESRRPCEKPACELGDWFT 722
                |..|:|:: |.||||.|::.|.|:|.||:  .|:..||.||.|||..|||..||  ..|..
  Rat  1023 ----WATSEWSE-CPVTCGKGMKQRQVWCQRSEDPVGDDFCDASTKPESLGPCELRAC--ASWHV 1080

  Fly   723 GPWSSCNGDCFDLTRTREVLCIRSQL--ITEHSECTPELKPQSVEKC------------------ 767
            |||.||...|....:.|.|.|:...|  :.:..||....:|...:.|
  Rat  1081 GPWGSCTVTCGHGYQVRAVKCVSEILGTVLDDRECPRASRPSDRQDCIFAPCLAILKVGATSLPA 1145

  Fly   768 ----------------------------------SHE---------------EVEYC---AARWH 780
                                              :|:               ||..|   ...|.
  Rat  1146 IPLGKAAQWRHGSWTPCSVSCGRGSQARYVSCRDAHDGVADELNCAHLPRPAEVSLCFSPCGEWQ 1210

  Fly   781 YSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNVQAC---------- 835
            ..|||.|:..||.|...|.|.|:.|    :.|.:.::|....|....:.|.:.||
  Rat  1211 AGDWSPCSASCGHGKTTRRVLCVNY----HQLVDESYCDPEGRPVTEQECRLAACPPSYSRSPSS 1271

  Fly   836 AEVP------------KTEVTP-------VCADKFSNCQWASQAKLCSYDYYRDNCCFSCTGGI 880
            :|.|            |.|..|       :..:::....|.:             |..||.||:
  Rat  1272 SEQPSHGPGRNVPLTHKPEENPDQGVQLSIRGNQWRTGPWGA-------------CSRSCAGGL 1322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	20/58 (34%)
		ADAM_spacer1	348..468	CDD:283607	35/128 (27%)
		TSP1	667..716	CDD:214559	25/50 (50%)
		TSP1	779..835	CDD:214559	16/55 (29%)
		PLAC	847..877	CDD:285849	3/29 (10%)
Adamts20	XP_038936261.1	Pep_M12B_propep	41..186	CDD:396235
		ZnMc_ADAMTS_like	257..463	CDD:239801	13/51 (25%)
		ADAM_CR_2	478..545	CDD:407643	9/82 (11%)
		TSP1	558..610	CDD:214559	20/58 (34%)
		ADAM_spacer1	720..838	CDD:368694	35/128 (27%)
		TSP1_ADAMTS	906..959	CDD:408800	15/66 (23%)
		TSP1_ADAMTS	968..1020	CDD:408800	15/66 (23%)
		TSP1_ADAMTS	1023..1075	CDD:408800	25/52 (48%)
		TSP1_ADAMTS	1078..1132	CDD:408800	15/53 (28%)
		TSP1_ADAMTS	1154..1206	CDD:408800	4/51 (8%)
		TSP1_ADAMTS	1209..1261	CDD:408800	16/55 (29%)
		TSP1_ADAMTS	1306..1357	CDD:408800	6/30 (20%)
		TSP1_ADAMTS	1360..1412	CDD:408800
		TSP1_ADAMTS	1418..1471	CDD:408800
		TSP1_ADAMTS	1474..1527	CDD:408800
		TSP1_ADAMTS	1532..1585	CDD:408800
		TSP1_ADAMTS	1657..1708	CDD:408800
		GON	1713..1880	CDD:400843

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910