DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and Adamts10

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001258374.1	Gene:	Adamts10 / 314655	RGDID:	1598320	Length:	1104	Species:	Rattus norvegicus

Alignment Length:	710	Identity:	177/710 - (24%)
Similarity:	269/710 - (37%)	Gaps:	169/710 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |..|:.|..|||||||||....|.|.:    ....:....|:|..:|::.||...|...|.|||.
  Rat   550 WGPWTPWGDCSRSCGGGVSSSSRHCDS----PRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFRE 610

  Fly   247 SQCSAYNDKEFHGHRYRWEPY----VKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFR 307
            .|||.::...|.|..|.|:.|    ||   .|.|.|:..|...:.....:|:||||| .|...
  Rat   611 MQCSEFDSVPFRGKFYTWKTYRGGGVK---ACSLTCLADGFNFYTERAAAVVDGTPC-RPDTV-- 669

  Fly   308 SQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCG--GLLCRPVTGIFTRNPLPEHAYIHVTTL 370
                  .:||.|.||.|.....:...........||  |..|..:.|:|: ..||...|..|..:
  Rat   670 ------DICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFS-PALPGTGYEDVVWI 727

  Fly   371 PVGASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTE 435
            |.|:.:|.|.:|..|::.|.|:...|..:..|....|:.......|..|  |...|.:.:..
  Rat   728 PKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTSQPHRLPLAGTTF--HLRQGPDQAQS--- 787

  Fly   436 WITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSS 500
             :.::|||..||.:||..: |....::|.:..||..::...
  Rat   788 -LEALGPINASLIIMVLAQ-AELPALRYRFNAPIARDALPP------------------------ 826

  Fly   501 RAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCT-HSVKPVLNENLLHCNT 564
                   ::|....::.|:..|.||:|..::.|..:......:...|: ||..|   :....|||
  Rat   827 -------YSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSAHSKLP---KRQRACNT 881

  Fly   565 QPCPAYWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCE---CPK 626
            :|||..|...:|..|..|...|:|.|.|.|.:.:::.....:|.:||.:.:||:.:.|:   ||.
  Rat   882 EPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACQGPMCPP 946

  Fly   627 NRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRS 691
            .                                    |...||:: |:.:||.|:.:|.|.|
  Rat   947 E------------------------------------WAALDWSE-CTPSCGPGLRHRVVLC--- 971

  Fly   692 KAGEQRCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSECT 756
            |:.:||   ||.|.                                               ..|.
  Rat   972 KSADQR---STLPP-----------------------------------------------GHCP 986

  Fly   757 PELKPQSVEKCSHEEVEYC-AARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRY 820
            |..||.|..:|:   :..| .|||..|:|.||:..||.|.|:|:|||..:     ..:.|..|..
  Rat   987 PAAKPPSTMRCN---LRRCPPARWVASEWGECSTQCGLGQQQRTVRCTSH-----TGQPSRECTE 1043

  Fly   821 TNREPIYRNCNVQACAEVPKTEVTPVCAD--KFSNCQWASQAKLCSYDYYRDNCCFSCTG 878
            ..|....:.|..:..:.||..:....|.|  |.:.|....:.:.||..|:|..||.:|.|
  Rat  1044 ALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQG 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	19/55 (35%)
		ADAM_spacer1	348..468	CDD:283607	30/119 (25%)
		TSP1	667..716	CDD:214559	15/48 (31%)
		TSP1	779..835	CDD:214559	17/55 (31%)
		PLAC	847..877	CDD:285849	10/31 (32%)
Adamts10	NP_001258374.1	Pep_M12B_propep	40..180	CDD:396235
		ZnMc_ADAMTS_like	239..454	CDD:239801
		ADAM_CR_2	469..537	CDD:407643
		TSP1	550..602	CDD:214559	19/55 (35%)
		ADAM_spacer1	706..818	CDD:368694	30/119 (25%)
		TSP1_ADAMTS	829..884	CDD:408800	14/57 (25%)
		TSP1_ADAMTS	888..944	CDD:408800	15/55 (27%)
		TSP1_ADAMTS	948..1002	CDD:408800	22/110 (20%)
		TSP1_ADAMTS	1007..1057	CDD:408800	17/54 (31%)
		PLAC	1070..1102	CDD:400844	10/31 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910