Protein Alignment loh and Adamtsl2

DIOPT Version :10

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: NP_001414019.1
• Gene: Adamtsl2 / 311827
• RGDID: 1305459
• Length: 957
• Species: Rattus norvegicus
• Alignment Length: 1012
• Identity: 224/1012 - (22%)
• Similarity: 326/1012 - (32%)
• Gaps: 354/1012 - (34%)

  Fly   139 SGNVATTRQTPKVEEVFSSPNPPQEATSSTSKKAKKKVYPYPRWDKWSDWSSCSRSCGGGVKYQV 203
            :|..|:|.         :|.|.|  .::|....|....|   .|.:|:.|::|||||||||..|.
  Rat    21 AGGAASTE---------ASDNSP--TSNSLEGGADATAY---WWGEWTKWTACSRSCGGGVTSQE 71

  Fly   204 RKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYV 268
            |.|:.:...:.....:..|||..||||||....|......||..||.::|.:.:.|..|:|:|..
  Rat    72 RHCLQQRRKSVPGAGNRTCVGTSKRYQLCRVQECPPDGRSFREEQCVSFNSRVYDGRAYQWKPLY 136

  Fly   269 KDD------AECELNCMPF-GMKSFATLNESVIDGTPCGHPAEYFRSQFWE-RAVCVDGACKAVQ 325
            .||      ..|:|:|... |.:.   |.....|||.|         :..: |.|||.|.|:.:.
  Rat   137 PDDYMHISSKPCDLHCTTVDGQRQ---LMVPARDGTSC---------KLTDLRGVCVSGKCEPIG 189

  Fly   326 ASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLPEH-AYIHVTTLPVGASNISITELKN 384
            ..|.   |::......||     |..|..|||.:.:.  ..| .|..||.:|.||.:|.|.|.|.
  Rat   190 CDGV---LFSTHTLDKCGVCQGDGSSCTHVTGNYRKG--DNHLGYSLVTHIPAGARDIQIVERKK 249

  Fly   385 SINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHR-IDGAEDSNGVTEWITSIGPIRDSLQ 448
            |.::|.|........|||...|....::...|.|..|.| :|..|  .|: |:|.:.||....|.
  Rat   250 SADVLALADEAGFYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYE--TGI-EYIVAQGPTNQGLN 311

  Fly   449 LMVFTKSANNTGVKYEYML----------PI-------VSES----------------------- 473
            :||:.::..:..:.:||.|          |:       .|||
  Rat   312 VMVWNQNGKSPSITFEYTLLQSPHMHHLPPVYYSFSEAASESTESTERQELDSARLLGFLQHNGS 376

  Fly   474 --------------------------------EENEMSLESSDG--------------------- 485
                                            |.||:..::|.|
  Rat   377 LYGQPSSERLGLNSQLFPPTAPEVELGPSRGQETNEVCKQASGGVCEGPPRGKGFQDHNATGRAL 441

  Fly   486 ---------------------------LLRSGME------------------------------- 492
                                       ||.:|.:
  Rat   442 LGDKDDREISAHFTSHELLSANTISDQLLGTGSDSEEFSLNETMNSIFAQGAPRSSPAESLYVDY 506

  Fly   493 --------------------------------DTSSSSSSRAG------------RKR------I 507
                                            :||:|..|.||            ||:      :
  Rat   507 EENEGPAAYLINGSYLELNSDRINTSSEAPFPNTSASLPSLAGNRTHKARTRPKARKQGVSPADM 571

  Fly   508 FNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLH--CNTQPCPAY 570
            :.||:.....|:.:|..|..:....|:|.:.:. .....|....:|    ..:|  |..:.|...
  Rat   572 YRWKLSSQEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRP----EPVHEFCAGRECQPR 631

  Fly   571 WRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQ---PPMQKQCECPKNRRRNL 632
            |....|.||..:...|.:.|.|.|.:.|:.|....|....|...:   |..:|.|..|
  Rat   632 WETSSWSECSRTCGEGHQFRIVRCWKMLSPGFDSSVYSDLCEATEAVRPEERKTCRNP------- 689

  Fly   633 SRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGS-GVEYRTVFCDRSKAGEQ 696
                ..||.                      |.:|:|:: |:..||. .|..|.:.|...   |:
  Rat   690 ----ACGPQ----------------------WEMSEWSE-CTAKCGERSVVTRDIRCSED---ER 724

  Fly   697 RCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQ-LITEHSECTPELK 760
            .|||:|.|...:.|..|.|: ..|....|..|:|.|......|.|.|..|. .:...|:|..|.|
  Rat   725 LCDPNTRPVGEKNCTGPPCD-RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQTETK 788

  Fly   761 PQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREP 825
            |.::..|..:.   |.|.|...||..|...||.|.::|.|.|:|.......:|..:.|....:.|
  Rat   789 PLAIHPCGDKN---CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQMRSGSECGLARKPP 850

  Fly   826 IYRNCNVQAC--------AEVPKT------------------------EVTPV------------ 846
            ....|..:.|        :|..||                        .|.||
  Rat   851 EESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 915

  Fly   847 ------CADK-FSNCQWASQAKLCSYDYYRDNCCFSC 876
                  |.|: .:||..|.:..||.:.||...||.||
  Rat   916 EPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	24/55 (44%)
		ADAMTS_spacer1	349..468	CDD:461796	38/130 (29%)
		TSP1_ADAMTS	510..567	CDD:465950	11/58 (19%)
		TSP1_ADAMTS	664..715	CDD:465950	17/51 (33%)
		TSP1_ADAMTS	720..768	CDD:465950	14/48 (29%)
		TSP1_ADAMTS	779..835	CDD:465950	15/55 (27%)
		PLAC	847..877	CDD:462560	13/31 (42%)
Adamtsl2	NP_001414019.1	None