DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and Adamtsl2

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_038962070.1	Gene:	Adamtsl2 / 311827	RGDID:	1305459	Length:	957	Species:	Rattus norvegicus

Alignment Length:	1012	Identity:	224/1012 - (22%)
Similarity:	326/1012 - (32%)	Gaps:	354/1012 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 SGNVATTRQTPKVEEVFSSPNPPQEATSSTSKKAKKKVYPYPRWDKWSDWSSCSRSCGGGVKYQV 203
            :|..|:|.         :|.|.|  .::|....|....|   .|.:|:.|::|||||||||..|.
  Rat    21 AGGAASTE---------ASDNSP--TSNSLEGGADATAY---WWGEWTKWTACSRSCGGGVTSQE 71

  Fly   204 RKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYV 268
            |.|:.:...:.....:..|||..||||||....|......||..||.::|.:.:.|..|:|:|..
  Rat    72 RHCLQQRRKSVPGAGNRTCVGTSKRYQLCRVQECPPDGRSFREEQCVSFNSRVYDGRAYQWKPLY 136

  Fly   269 KDD------AECELNCMPF-GMKSFATLNESVIDGTPCGHPAEYFRSQFWE-RAVCVDGACKAVQ 325
            .||      ..|:|:|... |.:.   |.....|||.|         :..: |.|||.|.|:.:.
  Rat   137 PDDYMHISSKPCDLHCTTVDGQRQ---LMVPARDGTSC---------KLTDLRGVCVSGKCEPIG 189

  Fly   326 ASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLPEH-AYIHVTTLPVGASNISITELKN 384
            ..|.   |::......||     |..|..|||.:.:.  ..| .|..||.:|.||.:|.|.|.|.
  Rat   190 CDGV---LFSTHTLDKCGVCQGDGSSCTHVTGNYRKG--DNHLGYSLVTHIPAGARDIQIVERKK 249

  Fly   385 SINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHR-IDGAEDSNGVTEWITSIGPIRDSLQ 448
            |.::|.|........|||...|....::...|.|..|.| :|..|  .|: |:|.:.||....|.
  Rat   250 SADVLALADEAGFYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYE--TGI-EYIVAQGPTNQGLN 311

  Fly   449 LMVFTKSANNTGVKYEYML----------PI-------VSES----------------------- 473
            :||:.::..:..:.:||.|          |:       .|||
  Rat   312 VMVWNQNGKSPSITFEYTLLQSPHMHHLPPVYYSFSEAASESTESTERQELDSARLLGFLQHNGS 376

  Fly   474 --------------------------------EENEMSLESSDG--------------------- 485
                                            |.||:..::|.|
  Rat   377 LYGQPSSERLGLNSQLFPPTAPEVELGPSRGQETNEVCKQASGGVCEGPPRGKGFQDHNATGRAL 441

  Fly   486 ---------------------------LLRSGME------------------------------- 492
                                       ||.:|.:
  Rat   442 LGDKDDREISAHFTSHELLSANTISDQLLGTGSDSEEFSLNETMNSIFAQGAPRSSPAESLYVDY 506

  Fly   493 --------------------------------DTSSSSSSRAG------------RKR------I 507
                                            :||:|..|.||            ||:      :
  Rat   507 EENEGPAAYLINGSYLELNSDRINTSSEAPFPNTSASLPSLAGNRTHKARTRPKARKQGVSPADM 571

  Fly   508 FNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLH--CNTQPCPAY 570
            :.||:.....|:.:|..|..:....|:|.:.:. .....|....:|    ..:|  |..:.|...
  Rat   572 YRWKLSSQEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRP----EPVHEFCAGRECQPR 631

  Fly   571 WRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQ---PPMQKQCECPKNRRRNL 632
            |....|.||..:...|.:.|.|.|.:.|:.|....|....|...:   |..:|.|..|
  Rat   632 WETSSWSECSRTCGEGHQFRIVRCWKMLSPGFDSSVYSDLCEATEAVRPEERKTCRNP------- 689

  Fly   633 SRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGS-GVEYRTVFCDRSKAGEQ 696
                ..||.                      |.:|:|:: |:..||. .|..|.:.|...   |:
  Rat   690 ----ACGPQ----------------------WEMSEWSE-CTAKCGERSVVTRDIRCSED---ER 724

  Fly   697 RCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQ-LITEHSECTPELK 760
            .|||:|.|...:.|..|.|: ..|....|..|:|.|......|.|.|..|. .:...|:|..|.|
  Rat   725 LCDPNTRPVGEKNCTGPPCD-RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQTETK 788

  Fly   761 PQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREP 825
            |.::..|..:.   |.|.|...||..|...||.|.::|.|.|:|.......:|..:.|....:.|
  Rat   789 PLAIHPCGDKN---CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQMRSGSECGLARKPP 850

  Fly   826 IYRNCNVQAC--------AEVPKT------------------------EVTPV------------ 846
            ....|..:.|        :|..||                        .|.||
  Rat   851 EESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 915

  Fly   847 ------CADK-FSNCQWASQAKLCSYDYYRDNCCFSC 876
                  |.|: .:||..|.:..||.:.||...||.||
  Rat   916 EPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	24/55 (44%)
		ADAM_spacer1	348..468	CDD:283607	38/131 (29%)
		TSP1	667..716	CDD:214559	16/49 (33%)
		TSP1	779..835	CDD:214559	15/55 (27%)
		PLAC	847..877	CDD:285849	13/31 (42%)
Adamtsl2	XP_038962070.1	TSP1	50..106	CDD:214559	24/55 (44%)
		ADAM_spacer1	216..330	CDD:368694	37/118 (31%)
		TSP1_ADAMTS	632..691	CDD:408800	16/69 (23%)
		TSP1_ADAMTS	695..743	CDD:408800	17/51 (33%)
		TSP1_ADAMTS	747..800	CDD:408800	15/55 (27%)
		TSP1_ADAMTS	804..860	CDD:408800	15/55 (27%)
		TSP1_ADAMTS	863..913	CDD:408800	6/49 (12%)
		PLAC	922..953	CDD:400844	13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910