DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and Adamts8

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_003750503.1	Gene:	Adamts8 / 300475	RGDID:	1308511	Length:	905	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	116/428 - (27%)
Similarity:	166/428 - (38%)	Gaps:	111/428 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNA---CVGYFKRYQLCNDVPCDEQSPD 243
            |..|..|..|||:||||:::..|:|       :|....|.   |:|...:||.|....|......
  Rat   545 WGPWGPWGQCSRTCGGGIQFSNREC-------DNPAPQNGGRFCLGERVKYQSCKTEECPPNGKS 602

  Fly   244 FRASQC---SAYNDKEFHGHRYRWEPY---VKDDAECELNCMPFGMKSFATLNESVIDGTPCGHP 302
            ||..||   :|||..:..|:..:|.|.   |.....|:|.|...|...|......|||||.||..
  Rat   603 FREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFETKVIDGTLCGPD 667

  Fly   303 AEYFRSQFWERAVCVDGAC-KA-----VQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTR 356
            .         .|:||.|.| ||     |.:..::|         .||     |..||.|:|.||
  Rat   668 T---------LAICVRGQCVKAGCDHVVNSPKKLD---------KCGVCGGKGTACRKVSGSFT- 713

  Fly   357 NPLPEHAYIHVTTLPVGASNISITE-----LKNSINLLVLRTSNELAIFNGENTVSESGSYEAV- 415
             |. .:.|..:.|:|.||:||.:.:     ::|..:.|.|:|:|...:.||...:|      |:
  Rat   714 -PF-SYGYNDIVTIPAGATNIDVKQRSHPGVQNDGSYLALKTANGQYLLNGNLAIS------AIE 770

  Fly   416 ------GAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSAN--NTGVKYEYMLPIVSE 472
                  |.:..|      ..|....|.:.|...:.:.|.:.:.|.|..  ...|||.:.:|
  Rat   771 QDILMKGTILKY------SGSMATLERLQSFQALPEPLTVQLLTVSGEVFPPKVKYTFFVP---- 825

  Fly   473 SEENEMSLESSDGLLRSGMEDTS---SSSSSRAGRKRI-----FNWKVIGFSSCTKSCGGGTQTP 529
                               .||.   .||..||....|     ..|.:..:|.|..:||||.|..
  Rat   826 -------------------NDTDFNVQSSKERASTNIIQSLPYAEWVLGDWSECPSTCGGGWQRR 871

  Fly   530 IIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNTQPC 567
            .:.|  ::|....|. .|..::||   |:...|.:|||
  Rat   872 TVEC--RDPSGQASD-TCDEALKP---EDAKPCGSQPC 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	19/58 (33%)
		ADAM_spacer1	348..468	CDD:283607	33/133 (25%)
		TSP1	667..716	CDD:214559
		TSP1	779..835	CDD:214559
		PLAC	847..877	CDD:285849
Adamts8	XP_003750503.1	Pep_M12B_propep	49..152	CDD:279848
		Reprolysin	234..444	CDD:279729
		ZnMc_ADAMTS_like	234..441	CDD:239801
		ADAM_CR	463..529	CDD:301627
		TSP1	545..597	CDD:214559	19/58 (33%)
		ADAM_spacer1	706..825	CDD:283607	33/133 (25%)
		TSP1	852..903	CDD:214559	17/56 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000