Protein Alignment loh and Adamts12

DIOPT Version :9

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: NP_001099890.2
• Gene: Adamts12 / 294809
• RGDID: 1307323
• Length: 1599
• Species: Rattus norvegicus
• Alignment Length: 1094
• Identity: 227/1094 - (20%)
• Similarity: 325/1094 - (29%)
• Gaps: 465/1094 - (42%)

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |.:||.||.|||:||.|.:...|.|.|    ...:.....|.|..|||:|||..||...:|.||.
  Rat   549 WGRWSPWSHCSRTCGAGAQSAERLCNN----PEPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQ 609

  Fly   247 SQCSAYNDKEFHGHRYRWEPYVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFW 311
            .|||.::...:....|||.|.......|||.|.|...:....:.|:|||||||.....
  Rat   610 MQCSEFDTVPYKNQFYRWFPVFNPAHPCELYCRPIDEQFSERMLEAVIDGTPCFEGGN------- 667

  Fly   312 ERAVCVDGACKAVQASGEIDGLYAHSGSVSCG-----GLLCRPVTGIFTRNPLPEHAYIHVTTLP 371
            .|.||::|.||.|....|||   :::....||     |..|:.|..:|.:.  ....||.:..:|
  Rat   668 SRNVCINGICKRVGCDYEID---SNATEDRCGVCLGDGSACQTVKKVFRQK--EGSGYIDIGLIP 727

  Fly   372 VGASNISITELKNSINLLVLRTSN-ELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTE 435
            .||.:|.:.|:|.:.|.|.:|:.: |....||...:..:|:|:..|.||.|       |..|..|
  Rat   728 KGARDIRVMEIKAAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQY-------DRKGDLE 785

  Fly   436 WITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSS 500
            .:.:.||..:|:.|.:..: ..|.|:||||.:              ..|||             .
  Rat   786 RLMAPGPTNESVWLQLLFQ-VTNPGIKYEYTV--------------RKDGL-------------D 822

  Fly   501 RAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKN---------------------------P 538
            ....|.::.|:...::.|:.:||.|.:.....|::|.                           |
  Rat   823 NDVEKLLYFWQFGRWTECSVTCGTGIRRQTAHCVKKGHGIVKTTFCNPETQPSVRQKKCYEKDCP 887

  Fly   539 LRY--------------YSQRR--------------------CTHSVKPVLNENLLHCNTQ-PCP 568
            .|:              |.:::                    |.|.:||   :.|:.||.. .||
  Rat   888 PRWWAGEWEACSMTCGPYGEKKRTVLCIQTMGSDEQALPATDCQHLLKP---KTLVSCNRDILCP 949

  Fly   569 AYWRFDDWGECRCSSSGGLRRREVSCVQEL----------------------------------- 598
            :.|...:|.||..|..||:|.|.|:|.:.|
  Rat   950 SDWTVGNWSECSVSCGGGVRIRSVTCAKNLNEPCDKTRKPNSRALCGLQQCPFSRRVLKPNKDTV 1014

  Fly   599 ----------------------------------------------------------------- 598
                                                                             
  Rat  1015 PSGKNPTTSEHDHFKPIPASTSRPTPLSTPTVPESVSTSTPTINSLGSTITSQEEPDGIGWQNNS 1079

  Fly   599 -----------------------------------------------------ASGL-------- 602
                                                                 .|||
  Rat  1080 TQAEEDSHIPTSVGSTSQTPLTSWSWSMQPDDENVSSSAIGPTSESDFWATTSDSGLSSSNAMTW 1144

  Fly   603 -VIHVDKAACME-------------DQP---------------------PMQKQCECP------- 625
             |......|..|             |||                     ||:...|.|
  Rat  1145 QVTPFYSTATTEPEVEIHSGSGEDSDQPLNKEENNSVLWNKIRVPERDAPMEMDAEIPLGPPPTS 1209

  Fly   626 ------------------------KNR----------------------RRNLSRYRL------- 637
                                    ||.                      .:..|..:|
  Rat  1210 YVTEESSWPPFSTMMKSSLPAWSFKNETPRDEGMITEKSGNIPLPLGGDHQTTSPEKLGNNDQLA 1274

  Fly   638 ----------SGP---SESSS---------NSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSG 680
                      |||   .|.:|         |:|..|....|.|.|.  |:|.:|:: ||.|||.|
  Rat  1275 SANSTNPTQGSGPVLTEEDASTLIEEGFLLNASNYKHLMKDHSPAH--WIVGNWSK-CSTTCGLG 1336

  Fly   681 VEYRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIR 745
            ..:|:|.|......:  |.....|:..:.|....|  ..|..|.||.|:.:|....:.|||.|:.
  Rat  1337 AYWRSVECSTGMNAD--CAAIQRPDPAKKCHLRPC--AGWRVGNWSKCSRNCSGGFKIREVQCMD 1397

  Fly   746 SQLITEHSECTP-----------------------ELKPQSVEKCS-------HEEVEYC----- 775
            .  :..|....|                       |.|.:...:||       .|...:|
  Rat  1398 G--VDHHRSLRPFHCQFLAGVPPPLSMSCNLEPCEEWKVEPWSQCSRSCGGGVQERGVFCPGGLC 1460

  Fly   776 ----------------AARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNRE 824
                            ...|...:|..||..||||:|:|:|.|:..:......::...|.:..|.
  Rat  1461 DWTKRPASTVPCNRHLCCHWATGNWELCTTSCGGGSQKRTVHCIPSENSTTEDQDQCFCDHQARP 1525

  Fly   825 PIYRNCNVQACAEVPKTEVTPVCADKFSN--CQWASQAKLCSYDYYRDNCCFSC 876
            |.::|||.|||.:......|   .|:.|.  ||.....|.||....|..||.||
  Rat  1526 PEFQNCNQQACRKSADLTCT---KDRLSTSFCQTLKSMKKCSVPSVRVQCCLSC 1576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	23/55 (42%)
		ADAM_spacer1	348..468	CDD:283607	35/120 (29%)
		TSP1	667..716	CDD:214559	13/48 (27%)
		TSP1	779..835	CDD:214559	19/55 (35%)
		PLAC	847..877	CDD:285849	12/32 (38%)
Adamts12	NP_001099890.2	Pep_M12B_propep	80..196	CDD:279848
		Reprolysin	250..460	CDD:279729
		ZnMc_ADAMTS_like	250..457	CDD:239801
		ADAM_CR	519..680	CDD:301627	53/141 (38%)
		TSP1	549..600	CDD:214559	22/54 (41%)
		ADAM_spacer1	706..816	CDD:283607	35/119 (29%)
		TSP1	832..887	CDD:214559	7/54 (13%)
		TSP1	950..1001	CDD:214559	12/50 (24%)
		PARM	1021..>1176	CDD:293666	9/154 (6%)
		TSP1	1429..1477	CDD:214559	6/47 (13%)
		TSP1	1479..1536	CDD:214559	19/56 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11210
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910