DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and Adamts19

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_006525982.1	Gene:	Adamts19 / 240322	MGIID:	2442875	Length:	1234	Species:	Mus musculus

Alignment Length:	868	Identity:	217/868 - (25%)
Similarity:	330/868 - (38%)	Gaps:	231/868 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KEEYLENETTSKISNKSDEKVLKSSTIISLNATNPSTSTFKSVLETTTLPSVT-TKD-----LF- 137
            |.:.|.:.:.|:.|.:..|:.|:|.....|..|:|  .:..|||..:.||.:. |.|     ||
Mouse   515 KGQNLGDVSWSRCSKEDLERFLRSKASSCLLHTDP--QSLSSVLVPSKLPGMAYTADEQCQILFG 577

  Fly   138 -------ESGNVATTRQTPKVE---EVFSSPNPPQEATSSTSKK-------AKKKVYPYPRWDKW 185
                   |..:|..|....|||   |..:..:||.:.|.....|       .::...|.....:|
Mouse   578 PLASFCQEMQHVICTGLWCKVEGEAECRTKLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLAGEW 642

  Fly   186 SDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNA--CVGYFKRYQLCNDVPCDEQSPDFRASQ 248
            |.||||||||..||..:.|||..        |.|.|  |.|..|:|::|.:.||....|.||..|
Mouse   643 SPWSSCSRSCSSGVSSRERKCPG--------LGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQ 699

  Fly   249 CSAYNDK-EFHGHRYRWEPYVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWE 312
            |.||:.: .:..|..:|:....::..|.|.|.|.|.:....|:|.|:|||.||:..
Mouse   700 CQAYSVRTSYPKHALQWQAVFDEEKPCALFCSPVGKEQPVLLSEKVMDGTSCGYQG--------- 755

  Fly   313 RAVCVDGACKAVQASGEIDGLYA--HSGSVSCGGLLCRPVTGIF--TRNPLPEHAYIHVTTLPVG 373
            ..:|.:|.|:.....|.:..|..  |.|..:..|..|:.:.|.|  ||..    .|:.|..:|.|
Mouse   756 LDICANGRCQKAGCDGLLGSLAREDHCGVCNGNGKSCKVIKGDFNHTRGA----GYVEVLVIPAG 816

  Fly   374 ASNISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWIT 438
            |..|.:.|.|.:.:.|.||.:::.:| |.:..:..||::...|....|.|       .|:.|.|:
Mouse   817 ARRIKVVEEKPAHSFLALRDASKQSI-NSDWKIEHSGAFSLAGTTVHYLR-------RGLWEKIS 873

  Fly   439 SIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAG 503
            :.||....|.|:|......|.|:.|||.:|              ||.|       ..:.||...|
Mouse   874 AKGPTTTPLHLLVLLFQDQNYGLHYEYTVP--------------SDPL-------PDNQSSKEPG 917

  Fly   504 RKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIR---KNPLRYYSQRRCTHSVKPVLNENLLHCNTQ 565
              .:|.|...|:..|..:||||.:..::.|.:   || :.....::|....||  ...:..||.|
Mouse   918 --PLFMWTHAGWGDCNATCGGGERKTMVSCTKIMSKN-ISLVDNKKCKDLTKP--EPQIRKCNEQ 977

  Fly   566 PCP------------------------AYWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHV 606
            ||.                        ..|...:|..|..:...|::.|:|:|.|:|.:|.:|..
Mouse   978 PCQTSPCGTVTTLRQTVCHQLYISVRFTRWMMTEWTTCSRTCGKGVQSRQVACTQQLENGTLIRA 1042

  Fly   607 DKAACMEDQPPMQKQCECPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQ 671
            .:..|:..:|...::||                                 |.|...:|....|::
Mouse  1043 WERDCLGPKPATVQRCE---------------------------------GQDCMTVWEAGVWSE 1074

  Fly   672 YCSVTCGSGVEYRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLT 736
             |||.||.||.:|||.|...:   ::|..||.|.....||
Mouse  1075 -CSVKCGKGVRHRTVRCTNPR---KKCVLSTRPREAEDCE------------------------- 1110

  Fly   737 RTREVLCIRSQLITEHSECTPELKPQSVEKCSHEEVEYCAARWHYSDWSECTKPCGGGTQRRSVR 801
                          ::|:|                  |.   |...|||:|:..||.|.|.|.::
Mouse  1111 --------------DYSKC------------------YV---WRVGDWSKCSITCGKGMQSRVIQ 1140

  Fly   802 CLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFS----NC---QW--- 856
            |:.   |:.. |....|..:.:...||.|::|.|.|  |..|..:.:.:.:    .|   ||
Mouse  1141 CMH---KITG-RHGNECFSSEKPAAYRPCHLQPCNE--KINVNTITSPRLAALTFKCLGDQWPVY 1199

  Fly   857 ---ASQAKLCSYDYYRDNCCFSC 876
               ..:..||....:...||.:|
Mouse  1200 CRVIREKNLCQDMRWYQRCCETC 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	24/57 (42%)
		ADAM_spacer1	348..468	CDD:283607	35/121 (29%)
		TSP1	667..716	CDD:214559	18/48 (38%)
		TSP1	779..835	CDD:214559	18/55 (33%)
		PLAC	847..877	CDD:285849	8/43 (19%)
Adamts19	XP_006525982.1	Pep_M12B_propep	161..276	CDD:366707
		ZnMc_ADAMTS_like	328..545	CDD:239801	7/29 (24%)
		ADAM_CR_2	562..629	CDD:375321	16/66 (24%)
		ADAM_spacer1	793..903	CDD:368694	35/121 (29%)
		TSP1	1010..1063	CDD:214559	15/85 (18%)
		TSP1	1066..1111	CDD:214559	19/87 (22%)
		TSP1	1115..1170	CDD:214559	20/79 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910