DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loh and Adamts17

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001029049.2	Gene:	Adamts17 / 233332	MGIID:	3588195	Length:	1122	Species:	Mus musculus

Alignment Length:	756	Identity:	195/756 - (25%)
Similarity:	288/756 - (38%)	Gaps:	199/756 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 NPPQEATSSTSKK---AKKKV--YPYPR-----WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLT 213
            :||.:.|...:.|   |.:.|  .|.|.     |..||.||.|||:||.|.:::.|||.|    .
Mouse   511 DPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSLWSAWSMCSRTCGTGARFRQRKCDN----P 571

  Fly   214 NNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRASQCSAYNDKEFHGHRYRWEPYVKDDAECELNC 278
            ........|.|....:..|..:||.:..|.||..||.|: |:.....|......|.||..|||.|
Mouse   572 PPGPGGTHCQGASVEHAACEKLPCPKGVPSFRDQQCQAH-DRLSSKKRGLLTAVVVDDKPCELYC 635

  Fly   279 MPFGMKSFATLNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVS-- 341
            .|.|.:|...:.:.|:||||||.         :|..:||.|.|:.:...|.|       ||.:
Mouse   636 SPLGKESPLLVADRVLDGTPCGP---------YEADLCVYGRCQKIGCDGII-------GSAAKE 684

  Fly   342 --CG-----GLLCRPVTGIFTRNPLPEHA----YIHVTTLPVGASNISITELKNSINLLVLRTSN 395
              ||     |..||.|.|.|:      |:    ||....:||||..|.:.|.|.:.:.|.|:.|:
Mouse   685 DRCGVCSGDGKTCRVVKGDFS------HSRGTGYIEAVVIPVGARRIRVVEDKPAHSFLALKDSS 743

  Fly   396 ELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTG 460
            :.:| |.:..:...|.::..|....|.|       .|:.|..::.||....|.|||......|.|
Mouse   744 KRSI-NSDWKIELPGEFQIAGTTVRYVR-------RGLWEKFSAKGPTTVPLHLMVLLFHDQNYG 800

  Fly   461 VKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGG 525
            :.|||.:|:...||......:..|.|                     |.|...|:..|:..||||
Mouse   801 IHYEYTIPVNQSSENQSEPAKPQDAL---------------------FLWTHSGWEGCSVQCGGG 844

  Fly   526 TQTPIIRCIR--KNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPAYWRFDDWGECRCSSSGGLR 588
            .:..|:.|.|  .......:...|..:.:|  ...:..||:.||.:.|....|..|..:...|::
Mouse   845 ERRTIVSCTRIVNKTTTLVNDSDCPQASRP--EPQVRRCNSHPCQSRWVTGQWSPCSATCEKGVQ 907

  Fly   589 RREVSCVQELASGLVIHVDKAACMEDQPPMQKQCECPKNRRRNLSRYRLSGPSESSSNSSQVKRS 653
            .|||:||.:|.:|..:......|.|.:|...:.||
Mouse   908 HREVTCVYQLQNGTHVTTRPIYCSEPRPTPVQSCE------------------------------ 942

  Fly   654 KIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAGEQRCDPSTTPESRRPCEKPACELG 718
               |.|..:||..|:|:: ||..||.|::.|||.|..|:.   :||.||.|::...||.
Mouse   943 ---GQDCLSIWEASEWSE-CSANCGKGIQKRTVTCTNSQG---KCDASTRPKAEEECED------ 994

  Fly   719 DWFTGPWSSCNGDCFDLTRTREVLCIRSQLITEHSECTPELKPQSVEKCSHEEVEYCAARWHYSD 783
              ::|        |::                                            |...|
Mouse   995 --YSG--------CYE--------------------------------------------WKTGD 1005

  Fly   784 WSECTKPCGGGTQRRSVRCLEYDIKMNALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCA 848
            ||:|:..||.|.|.|.|:|:.   |:.. |..:.|...::...||.|:.:.|.|  |..|..:.:
Mouse  1006 WSKCSSTCGKGLQSRVVQCMH---KLTG-RHGSECPTLSKPAAYRQCHQEVCNE--KINVNTITS 1064

  Fly   849 DKFS----NC---QWA------SQAKLCSYDYYRDNCCFSC 876
            .:.:    .|   ||.      .:..||....:...||.:|
Mouse  1065 PRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	19/55 (35%)
		ADAM_spacer1	348..468	CDD:283607	36/123 (29%)
		TSP1	667..716	CDD:214559	19/48 (40%)
		TSP1	779..835	CDD:214559	18/55 (33%)
		PLAC	847..877	CDD:285849	8/43 (19%)
Adamts17	NP_001029049.2	Pep_M12B_propep	75..179	CDD:279848
		Reprolysin	230..447	CDD:279729
		ZnMc_ADAMTS_like	230..447	CDD:239801
		TSP1	544..596	CDD:214559	19/55 (35%)
		ADAM_spacer1	698..808	CDD:283607	36/123 (29%)
		TSP_1	892..946	CDD:278517	16/86 (19%)
		TSP1	950..994	CDD:214559	19/47 (40%)
		TSP1	1001..1053	CDD:214559	18/55 (33%)
		PLAC	1080..1106	CDD:285849	5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910