DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and Adamts2

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_783574.1	Gene:	Adamts2 / 216725	MGIID:	1347356	Length:	1213	Species:	Mus musculus

Alignment Length:	707	Identity:	175/707 - (24%)
Similarity:	272/707 - (38%)	Gaps:	148/707 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |..|:.:.||||:||.|||::.|:|.|.:.....:    .|.|....:||||...|.....|||.
Mouse   565 WGAWTPFGSCSRTCGTGVKFRTRQCDNPHPANGGR----TCSGLAYDFQLCNPQDCPNSLADFRE 625

  Fly   247 SQCSAYNDKEFHGH-RYRWEPYVKDDAE--CELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRS 308
            .||..::....||. ::.|.|:...||:  |.|.|.........::...|.|||.|.:...:
Mouse   626 EQCQQWDLYFEHGDVQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAF--- 687

  Fly   309 QFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCGG--LLCRPVTGIFTRNPLPEHAYIHVTTLP 371
                 ::||.|.|:.|...|.|...........|||  ..|:.|.|.|||:|..:. ||.:..:|
Mouse   688 -----SLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQD-YIKMFEIP 746

  Fly   372 VGASNISITEL-KNSINLLVLRTSNELAIFNGENTVS-ESGSYEAVGAVFDYHRIDGAEDSNGVT 434
            .||.::.|.|. ..|.:|.|........|.|.||.:. .|.|:.|:|..::|..    ||..
Mouse   747 AGARHLLIQEADTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEYRN----EDER--- 804

  Fly   435 EWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSS 499
            |.:.:|||:..::.::|..:......:.|:||:        :|.||...|   .:.:||.:..
Mouse   805 ETLQTIGPLHGTITVLVIPEGDTRISLTYKYMI--------HEDSLNVDD---NNVLEDDAVR-- 856

  Fly   500 SRAGRKRIFNWKVIGFSSCTKSCGGGTQTPIIRCIRKNPLRYYSQRRCTHSVKPVLNENLLHCNT 564
                    ..|.:..:|.|:|.||||:|.....|.|:...:...:..|:...||......  ||.
Mouse   857 --------HEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRA--CNP 911

  Fly   565 QPC-PAYWRFDDWGECRCSSSG--GLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCE--- 623
            |.| ...|...:|..| ..|.|  |::.|.|.|:|.|.:.....|....|.:.:|..::.|.
Mouse   912 QECSQPVWVTGEWEPC-TQSCGRTGMQVRSVRCIQPLHNNTTRSVHTKHCNDHRPESRRACNREL 975

  Fly   624 CPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQYCSVTCGSGVEYRTVFC 688
            ||..                                    |....|:| ||||||:|.:.|.|.|
Mouse   976 CPGR------------------------------------WRAGSWSQ-CSVTCGNGTQERPVLC 1003

  Fly   689 DRSK-----AGEQRCDPSTTPESRRPCEKPACELGDWFTGPWSSCNGDCFDLTRTREVLCIRSQL 748
            ..:.     ..|:|      ||:.|.|....|..           ||.  |.::...|:    |.
Mouse  1004 RTADDNFGVCREER------PETARICRLAPCPR-----------NGS--DPSKKSYVV----QW 1045

  Fly   749 ITEHSECTPELKPQSVEKCSHEEVEYC----AARW----HYSDWSECTKPCG----------GGT 795
            ::.....:|..|..|.::|..::..:|    .:|:    .|:  ..|.|.|.          ||.
Mouse  1046 LSRPDPDSPIQKISSKDQCQGDKSMFCRMEVLSRYCSIPSYN--KLCCKSCNPPRNLSNTEDGGV 1108

  Fly   796 QRRSVRCLEYDIKMNAL---RESTHCRYTNREPIYRNCNV---QACAEVPKTEVTPV 846
            :....:..:.|:.|..|   ..:|..:.:...|:....||   .|..:.|:|....|
Mouse  1109 EPPPGKHNDIDVFMPTLPGPTVATQVQPSPGPPLEAPLNVSSTNATEDHPETNAVDV 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	20/55 (36%)
		ADAM_spacer1	348..468	CDD:283607	35/121 (29%)
		TSP1	667..716	CDD:214559	18/53 (34%)
		TSP1	779..835	CDD:214559	13/75 (17%)
		PLAC	847..877	CDD:285849	175/707 (25%)
Adamts2	NP_783574.1	Pep_M12B_propep	99..210	CDD:279848
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..232
		ZnMc_ADAMTS_like	267..468	CDD:239801
		Reprolysin	269..471	CDD:279729
		TSP1	565..617	CDD:214559	20/55 (36%)
		Cell attachment site. /evidence=ECO:0000255	692..694		0/1 (0%)
		Spacer	723..851		40/146 (27%)
		ADAM_spacer1	724..838	CDD:283607	35/129 (27%)
		TSP1	864..915	CDD:214559	16/52 (31%)
		TSP1	918..977	CDD:214559	15/59 (25%)
		TSP1	983..1030	CDD:214559	18/53 (34%)
		PLAC	1064..1094	CDD:285849	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000