Protein Alignment loh and adt-3

DIOPT Version :9

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: NP_508681.3
• Gene: adt-3 / 180675
• WormBaseID: WBGene00020567
• Length: 940
• Species: Caenorhabditis elegans
• Alignment Length: 617
• Identity: 123/617 - (19%)
• Similarity: 207/617 - (33%)
• Gaps: 244/617 - (39%)

  Fly   182 WDKWSDWSSCSRSCGG-----GVKYQVRKCINRNLLTNNQLTSN----ACVGYFKRYQLCNDVPC 237
            |..|:|  ..:.:|||     .::.|:|  |.|::...|..:||    .|.|...|..:|:...|
 Worm   515 WSTWND--RPAPTCGGRCSQCEIRGQIR--IMRSIRQCNNPSSNNGGAPCQGDEARGMVCHRDVC 575

  Fly   238 DEQSPDFRASQ-CSAYNDKE------FHGHRYRWEPYVKDDAECELNCMPFGMKSFATLNESVID 295
            :..|.:..|:: ||...|:.      ..|...::|     .|.|::.|:..|..:..|:: :..|
 Worm   576 NGDSIENYATRVCSRLRDENAIPNTILSGEGMQFE-----QAMCKIWCLISGSTNIRTVS-NFPD 634

  Fly   296 GTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCGGLLCRPVTGIFTRNPLP 360
            |.||| |.:|          |:.|.|:.                     |||
 Worm   635 GAPCG-PGQY----------CIKGECRP---------------------LLC------------- 654

  Fly   361 EHAYIHVTTLPVGASNISITELKNSINLLVLRTSNELA-IFNGENTVSESGSYEAVGAVFDYHRI 424
                        |::.::.:|....:::|...|:..:. :.:.:....::..|:      ::.:.
 Worm   655 ------------GSTTLAYSEADCPLSVLQTTTTPPMPHVHSVDQFAGKTNPYK------EHKKT 701

  Fly   425 DGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRS 489
            ....:.:|.:.|...:            |...:..|||..
 Worm   702 PFLNEWSGWSVWSECV------------TYDCHTQGVKVR------------------------- 729

  Fly   490 GMEDTSSSSSSRAGRKRIFNWKVIGFSSCTKSCGGG----TQTPIIRCIRKNPLRYYSQRRCTHS 550
             :....:...:.|.|:|         ..||:.|.|.    |.:|        |.:.:..|    .
 Worm   730 -VRRCLAGVCAGALRER---------QPCTRPCTGSERPLTTSP--------PQQTFRNR----F 772

  Fly   551 VKPVLNE--NLLHCNTQPCPAYWRFDDWG-----ECRCSSSGGLRRREVSCV-QELASGLVIHVD 607
            :.|:.|.  |::         ..:.|.||     ...|.:...||||| :|: ||
 Worm   773 IAPLPNRQTNMI---------LRKVDHWGPWSACSVTCGTGQKLRRRE-NCIGQE---------- 817

  Fly   608 KAACMEDQPPMQKQCECPKNRRRNLSRYRLSGPSESSSNSSQVKRSKIDGSDATAIWLVSDWNQY 672
               |.|..|.:.:.|...||                                   .|  ::|:|:
 Worm   818 ---CAETGPCVMQSCRENKN-----------------------------------TW--TEWSQW 842

  Fly   673 --CSVTCGSGVEYR-----TVFCDRSKAGE------QRCDPSTTPESRRPCEKPACELGDWFTG- 723
              |||.||.||::|     ..|| |.|..:      |||..:||   |||....:   |.| ||
 Worm   843 SDCSVNCGEGVQFRKRACFAAFC-RGKDSDVRNCYGQRCSETTT---RRPLVNRS---GLW-TGW 899

  Fly   724 -PWSSCNGDCFDLTRTREVLCIRSQLITEHSE 754
             .||||:..|....|||...|.:...:.:.:|
 Worm   900 SSWSSCSTKCGIGQRTRRRRCYQGSCLGDDNE 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	17/64 (27%)
		ADAM_spacer1	348..468	CDD:283607	11/120 (9%)
		TSP1	667..716	CDD:214559	22/61 (36%)
		TSP1	779..835	CDD:214559
		PLAC	847..877	CDD:285849
adt-3	NP_508681.3	ZnMc_ADAMTS_like	201..416	CDD:239801
		ADAM_CR_2	434..502	CDD:375321
		TSP_1	<699..751	CDD:387593	11/98 (11%)
		TSP1	791..829	CDD:214559	14/51 (27%)
		TSP1	836..881	CDD:214559	17/47 (36%)
		TSP1	896..940	CDD:214559	13/37 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910