Protein Alignment loh and gon-1

DIOPT Version :9

• Sequence 1: NP_609406.2
• Gene: loh / 34435
• FlyBaseID: FBgn0032252
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: NP_001255448.1
• Gene: gon-1 / 177850
• WormBaseID: WBGene00001650
• Length: 2165
• Species: Caenorhabditis elegans
• Alignment Length: 1039
• Identity: 225/1039 - (21%)
• Similarity: 333/1039 - (32%)
• Gaps: 405/1039 - (38%)

  Fly   181 RWDKWSDWSSCSRSCGGGVKYQVRKC-----------INRNLLTNNQLTSNACVGYFKRYQLCND 234
            :|..|..|..|||:|||||:..:|.|           :..|:.:..:.....|||..:||:.||.
 Worm   590 QWGDWRSWGECSRTCGGGVQKGLRDCDSPKSENEVETLKSNVTSRPRNGGKYCVGQRERYRSCNT 654

  Fly   235 VPCDEQSPDFRASQCSAYNDKEF--------HGHRYRWEP---YVKDDAECELNCMPFGMKSFAT 288
            ..|...:..:|..|||.:|:|:.        :.|   |.|   .|..:..|:|.|...|..:|..
 Worm   655 QECPWDTQPYREVQCSEFNNKDIGIQGVASTNTH---WVPKYANVAPNERCKLYCRLSGSAAFYL 716

  Fly   289 LNESVIDGTPCGHPAEYFRSQFWERAVCVDGACKAVQASGEIDGLYAHSGSVSCGG--LLCRPVT 351
            |.:.|:|||||....:         .:||.|||.......::...........|||  ..|:.|.
 Worm   717 LRDKVVDGTPCDRNGD---------DICVAGACMPAGCDHQLHSTLRRDKCGVCGGDDSSCKVVK 772

  Fly   352 GIFTRNPLPEHAYIHVTTLPVGASNISITE-----LKNSINLLVLRTSNELAIFNGENTVSESGS 411
            |.|  |......|..|..:|.|::||.|.:     :|...|.|.||.:|...:.||...||.:..
 Worm   773 GTF--NEQGTFGYNEVMKIPAGSANIDIRQKGYNNMKEDDNYLSLRAANGEFLLNGHFQVSLARQ 835

  Fly   412 YEAV-GAVFDYHRIDGAEDSNGVTEWITSIGPIRDSLQLMVFTKSANNTGVKYEYML-------- 467
            ..|. ..|.:|      ..|:.:.|.|...||||..:.:.|.:..::...:.||||.
 Worm   836 QIAFQDTVLEY------SGSDAIIERINGTGPIRSDIYVHVLSVGSHPPDISYEYMTAAVPNAVI 894

  Fly   468 -PIVS--------------------ESEENEMSLESS-------------------------DGL 486
             ||.|                    :..:..|.|:.|                         |..
 Worm   895 RPISSALYLWRVTDTWTECDRACRGQQSQKLMCLDMSTHRQSHDRNCQNVLKPKQATRMCNIDCS 959

  Fly   487 LRSGMEDTSSSSS---SRAGRKRIFNWKVIG---------------------------------- 514
            .|...||.||.|:   |...|:|:...|:.|
 Worm   960 TRWITEDVSSCSAKCGSGQKRQRVSCVKMEGDRQTPASEHLCDRNSKPSDIASCYIDCSGRKWNY 1024

  Fly   515 -----------------------------------------------------------FSSCTK 520
                                                                       :|.|::
 Worm  1025 GEWTSCSETCGSNGKMHRKSYCVDDSNRRVDESLCGREQKEATERECNRIPCPRWVYGHWSECSR 1089

  Fly   521 SCGGGTQTPIIRCI----------RKNPLR-----------------------------YYSQRR 546
            ||.||.:....:|:          |..|.:                             .|....
 Worm  1090 SCDGGVKMRHAQCLDAADRETHTSRCGPAQTQEHCNEHACTWWQFGVWSDCSAKCGDGVQYRDAN 1154

  Fly   547 CTHSVKPVLNEN---------LLHCNTQPCPAYWRFDDWGECRCSSSGGLRRREVSCVQELASGL 602
            ||...:.||.|:         ...|:.:.||.| :..:|.:|..|...|...|.||||    ||.
 Worm  1155 CTDRHRSVLPEHRCLKMEKIITKPCHRESCPKY-KLGEWSQCSVSCEDGWSSRRVSCV----SGN 1214

  Fly   603 VIHVDKAAC--MEDQPPMQKQCE---CPKNRRRNLSR-----------------YRLSGPSESSS 645
            ...||.:.|  ..|:|...:.|.   ||..|..:.|.                 ||     |.|.
 Worm  1215 GTEVDMSLCGTASDRPASHQTCNLGTCPFWRNTDWSACSVSCGIGHRERTTECIYR-----EQSV 1274

  Fly   646 NSSQVKRSKIDGSDAT------AIWLVSDWNQYCSVTCGSGVEYRTVFCDRSKAG----EQRCDP 700
            ::|....:|:..:..|      ..|..|.|:. ||||||||::.|:|.|.|...|    |..||.
 Worm  1275 DASFCGDTKMPETSQTCHLLPCTSWKPSHWSP-CSVTCGSGIQTRSVSCTRGSEGTIVDEYFCDR 1338

  Fly   701 STTPESRRPCEKPACE--------LGD-----WFTGPWSSCNGDCFDLT---------------- 736
            :|.|..::.|||..|:        ..|     |.||||::|:..|.:.|
 Worm  1339 NTRPRLKKTCEKDTCDGPRVLQKLQADVPPIRWATGPWTACSATCGNGTQRRLLKCRDHVRDLPD 1403

  Fly   737 ----------------------------------------RTREVLCIRSQ----LITEHSECTP 757
                                                    ::|.|.|:.::    .|.:..:|..
 Worm  1404 EYCNHLDKEVSTRNCRLRDCSYWKMAEWEECPATCGTHVQQSRNVTCVSAEDGGRTILKDVDCDV 1468

  Fly   758 ELKPQSVEKCSHEEVEYC------AARWHYSDWSECTKPCGGGTQRRSVRCLEYDIKMNALREST 816
            :.:|.|...|   .:|.|      ...|...|||:|:..||||.:||||.|           .|:
 Worm  1469 QKRPTSARNC---RLEPCPKGEEHIGSWIIGDWSKCSASCGGGWRRRSVSC-----------TSS 1519

  Fly   817 HCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFSNCQWASQAKLCSYDYYRDNCCFSCTGGI 880
            .|..|.:..::..||.:.|        .|:..:.:....|.             :|..||.||:
 Worm  1520 SCDETRKPKMFDKCNEELC--------PPLTNNSWQISPWT-------------HCSVSCGGGV 1562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	21/66 (32%)
		ADAM_spacer1	348..468	CDD:283607	36/134 (27%)
		TSP1	667..716	CDD:214559	23/52 (44%)
		TSP1	779..835	CDD:214559	19/55 (35%)
		PLAC	847..877	CDD:285849	3/29 (10%)
gon-1	NP_001255448.1	Pep_M12B_propep	93..228	CDD:279848
		Reprolysin	280..493	CDD:279729
		ZnMc_ADAMTS_like	280..490	CDD:239801
		TSP1	591..658	CDD:214559	21/66 (32%)
		ADAM_spacer1	769..885	CDD:283607	34/123 (28%)
		TSP1	1022..1077	CDD:214559	0/54 (0%)
		TSP1	1079..1129	CDD:214559	9/49 (18%)
		TSP1	1131..1185	CDD:214559	7/53 (13%)
		TSP1	1190..1242	CDD:214559	17/55 (31%)
		TSP1	1247..1296	CDD:214559	8/53 (15%)
		TSP1	1296..1354	CDD:214559	24/58 (41%)
		TSP1	1371..1424	CDD:214559	8/52 (15%)
		TSP1	1493..1539	CDD:214559	20/64 (31%)
		TSP1	1546..1599	CDD:214559	6/30 (20%)
		TSP1	1640..1695	CDD:214559
		TSP1	1697..1751	CDD:214559
		TSP1	1813..1881	CDD:214559
		TSP1	1886..1938	CDD:214559
		GON	1942..2137	CDD:285848

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910