DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loh and madd-4

DIOPT Version :9

Sequence 1:	NP_609406.2	Gene:	loh / 34435	FlyBaseID:	FBgn0032252	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_492405.3	Gene:	madd-4 / 172706	WormBaseID:	WBGene00009958	Length:	1045	Species:	Caenorhabditis elegans

Alignment Length:	726	Identity:	166/726 - (22%)
Similarity:	247/726 - (34%)	Gaps:	206/726 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WDKWSDWSSCSRSCGGGVKYQVRKCINRNLLTNNQLTSNACVGYFKRYQLCNDVPCDEQSPDFRA 246
            |..||.||||:::|||||..|:|:|          |||. |.|...|:::|....|:.:|...|.
Worm    26 WAAWSPWSSCTKTCGGGVSRQLRRC----------LTSK-CSGESVRFKVCAQKTCESKSRLARD 79

  Fly   247 SQCSAYNDKEFHGHRYRWEPYVKDDAECELNCMPFGMKSFATLNESVIDGTPCGHPAEYFRSQFW 311
            :.|....              :....:||:.|.  ...:.|.....|.|||||        ....
Worm    80 TICGGEE--------------IVSRGQCEVVCR--SRLTGANFLWRVDDGTPC--------QAAT 120

  Fly   312 ERAVCVDGACKAVQASGEIDGLYAHSGSVSCGGLLCRPVTGIFTRNPLPEHAYIHVTTLPVGASN 376
            .||||..|:|:.|...|.|...:.......|||           |....:
Worm   121 SRAVCSKGSCQIVGCDGLISSSFRFDACGVCGG-----------RGDTCD--------------- 159

  Fly   377 ISITELKNSINLLVLRTSNELAIFNGENTVSESGSYEAVGAVFDYHRIDGAEDSNGVTEWITSIG 441
                                    ||:.....|..|.|.           |.:.:.:.:|..:..
Worm   160 ------------------------NGKFIWKVSEEYTAC-----------ASNCDDIVDWSGAGR 189

  Fly   442 PIRDSLQLMVFTKSANNTGVKYEYMLPIVSESEENEMSLESSDGLLRSGMEDTSSSSSSRAGRKR 506
            .|..:.|.:|...:|            |.......::..:.    ||..:|...........|.|
Worm   190 SIASTSQPIVVCVNA------------ITGRVVPEKLCADK----LRPKVEARPCPMLICPSRCR 238

  Fly   507 IFNWKVIGFSSCTKSCGGGTQTPIIRCIR--KNPLRYYSQRRCTHSVKPVLNENLLHCNTQPCPA 569
               |....::.|...||.||:...:.|::  .|...:.....|.:..:|...||   |.:..| .
Worm   239 ---WMAADWTECVPHCGEGTRKREVYCVQTAHNVTVHVPDTFCENGTRPAAEEN---CVSTSC-G 296

  Fly   570 YWRFDDWGECRCSSSGGLRRREVSCVQELASGLVIHVDKAACMEDQPPMQKQCECPKNRRRNLSR 634
            .|....|.:|..|...|:|||.|:|           |..:.|.|...|.| :..|
Worm   297 RWEAGKWSKCTASCGQGVRRRHVAC-----------VGGSDCDEGGRPRQ-ETTC---------- 339

  Fly   635 YRLSG-PSESSSNSSQVK-RSKIDGSDATAIWLVSDWN---------QYCSVTCGSGVEYRTVFC 688
              .:| |...::||.... |:.:||:...::...:||.         ..||.|||:||..|||.|
Worm   340 --YAGIPCSIATNSLDWNDRAYLDGNTFGSMDNHNDWQAPRLVAGEWSTCSSTCGTGVMSRTVEC 402

  Fly   689 --------DRSKAGEQRCDPSTTPESRRPCEKPACELGD------------WFTGPWSSCNGDCF 733
                    ...|.....|.....|:....||..:|.|.:            |..|.|:.|:..|.
Worm   403 VAVNPISSAPIKLPMSECQDQEQPKLFESCEVRSCPLQEDSKLSEDEAPYQWRYGDWTQCSASCL 467

  Fly   734 DLTRTREVLCIRSQLIT----EHSECTPELK-PQSVEKCSHEEVEYCAARWHYSDWSECTKPCGG 793
            ...:...:.||  |:.|    :.|:|....: |:....|:...   |...|..|.:|:|:..||.
Worm   468 GGKQKAALKCI--QVSTGKSVQWSQCDARRRPPEKSRPCNQHP---CPPFWLTSKYSDCSMSCGS 527

  Fly   794 GTQRRSVRCLEYDIKMN------ALRESTHCRYTNREPIYRNCNVQACAEVPKTEVTPVCADKFS 852
            ||.||||:|.:...|.:      .||:. .|.:...:.. ..|||.||   |.|.||
Worm   528 GTARRSVKCAQTVSKTDGADAHIVLRDD-RCHFKKPQET-ETCNVVAC---PATWVT-------- 579

  Fly   853 NCQWASQAKLC 863
             .||...::.|
Worm   580 -AQWTECSRSC 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loh	NP_609406.2	TSP1	182..238	CDD:214559	22/55 (40%)
		ADAM_spacer1	348..468	CDD:283607	12/119 (10%)
		TSP1	667..716	CDD:214559	18/65 (28%)
		TSP1	779..835	CDD:214559	20/61 (33%)
		PLAC	847..877	CDD:285849	3/17 (18%)
madd-4	NP_492405.3	TSP1	26..71	CDD:214559	22/55 (40%)
		TSP1	382..438	CDD:214559	16/55 (29%)
		IGc2	666..723	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910